ID A0A210QP60_MIZYE Unreviewed; 1165 AA.
AC A0A210QP60;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 08-NOV-2023, entry version 22.
DE RecName: Full=alpha-1,2-Mannosidase {ECO:0000256|RuleBase:RU361193};
DE EC=3.2.1.- {ECO:0000256|RuleBase:RU361193};
GN ORFNames=KP79_PYT04543 {ECO:0000313|EMBL:OWF50523.1};
OS Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Pectinida; Pectinoidea; Pectinidae;
OC Mizuhopecten.
OX NCBI_TaxID=6573 {ECO:0000313|EMBL:OWF50523.1, ECO:0000313|Proteomes:UP000242188};
RN [1] {ECO:0000313|Proteomes:UP000242188}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PY_sf001 {ECO:0000313|Proteomes:UP000242188};
RX PubMed=28812685; DOI=10.1038/s41559-017-0120;
RA Wang S., Zhang J., Jiao W., Li J., Xun X., Sun Y., Guo X., Huan P.,
RA Dong B., Zhang L., Hu X., Sun X., Wang J., Zhao C., Wang Y., Wang D.,
RA Huang X., Wang R., Lv J., Li Y., Zhang Z., Liu B., Lu W., Hui Y., Liang J.,
RA Zhou Z., Hou R., Li X., Liu Y., Li H., Ning X., Lin Y., Zhao L., Xing Q.,
RA Dou J., Li Y., Mao J., Guo H., Dou H., Li T., Mu C., Jiang W., Fu Q.,
RA Fu X., Miao Y., Liu J., Yu Q., Li R., Liao H., Li X., Kong Y., Jiang Z.,
RA Chourrout D., Li R., Bao Z.;
RT "Scallop genome provides insights into evolution of bilaterian karyotype
RT and development.";
RL Nat. Ecol. Evol. 1:120-120(2017).
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|PIRSR:PIRSR601382-2};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 47 family.
CC {ECO:0000256|ARBA:ARBA00007658, ECO:0000256|RuleBase:RU361193}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWF50523.1}.
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DR EMBL; NEDP02002575; OWF50523.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A210QP60; -.
DR STRING; 6573.A0A210QP60; -.
DR EnsemblMetazoa; XM_021497761.1; XP_021353436.1; LOC110450302.
DR OrthoDB; 942598at2759; -.
DR Proteomes; UP000242188; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004571; F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 1.50.10.10; -; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR InterPro; IPR044674; EDEM1/2/3.
DR InterPro; IPR001382; Glyco_hydro_47.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR036026; Seven-hairpin_glycosidases.
DR PANTHER; PTHR45679; ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR45679:SF2; ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 3; 1.
DR Pfam; PF01532; Glyco_hydro_47; 1.
DR Pfam; PF02225; PA; 1.
DR PRINTS; PR00747; GLYHDRLASE47.
DR SUPFAM; SSF52025; PA domain; 1.
DR SUPFAM; SSF48225; Seven-hairpin glycosidases; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|PIRSR:PIRSR601382-2};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycosidase {ECO:0000256|RuleBase:RU361193};
KW Hydrolase {ECO:0000256|RuleBase:RU361193};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR601382-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000242188};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..28
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 678..770
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
FT REGION 808..866
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1055..1165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 844..860
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1083..1099
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1138..1165
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 130
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR601382-1"
FT ACT_SITE 275
FT /evidence="ECO:0000256|PIRSR:PIRSR601382-1"
FT ACT_SITE 369
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR601382-1"
FT ACT_SITE 387
FT /evidence="ECO:0000256|PIRSR:PIRSR601382-1"
FT BINDING 473
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR601382-2"
SQ SEQUENCE 1165 AA; 131231 MW; 6542E3870922A85F CRC64;
MRTQKIVIIS MVVILIIFIV EDSVVLGMSS SEKGELRDKV LEMFRHAYDS YMNHAFPADE
LMPLSCKGRY RGTMPSRGDI DDSLGNFTLT LIDTLDTLVV LGEIEEFEKA VHLVIEHAKF
DSDIIVSVFE TNIRVLGGLL GGHVVATFLK KKKKSMDWYN DELLSMAKEV GYRLLPAFNT
STGIPYARVN LKHGITKELS NRCKDTCTAC AGTMVLEFAA LSRLTGEPIF EEKAHKAMDY
LWQQRHRTSD LVGTVINIHS GDWIRRESGV GAGIDSYYEY VLKAYILLGD DTYLQRFNKH
YDAVMKYISQ GPMFVDVHMH KPLSISRHFM DSLLAFWPGL QVLKGDIKPA METHEMLYQI
MQRHNFLPEA FTTDFRVHWG HHPLRPEFVE STYFLYKATG DPHYLNVGKE VINNLNTYAR
VDCGFAAIKD VTTGVHEDQM DSYVLAETFK YLYLMFSEKS DRVLDIDDYI FTTEAHLLPL
TLSTLSVTNV TARLPKVRSE VYQDMGDFSE SFESMSHPSD TVYLEDNKHH TCPNLQHLYQ
GTNNYAFNLR SKVQNMVDKY TTNSKREGHK PRLRAADFIA GNKAQLDLLL LMGIKIATMA
DGRVQLLHTA GEAASPEDAE DGMKFMQEMI ELSRHQQQET QHDPMIVQVL SDPYFGSLSF
KAGPAQFGYS LKTNPPIQGH VVKADPFSAC SSINNFEEVE AKIVIIERGN CMFVDKARNL
QKAGAKGSIV IDNTEGSSSD SHALFAMSGD GQQDVEIPLV FLFHKEGQTI LKLLEEFPNL
EVLLGEREMN AEAFLPKEPQ SLIEQNLEAN GPTCGGNTAK KAKDPATDDA GDSPDIVQTP
EATDTKPSKH RVHIRETREG NTYRLPTSSG HVQLVVDVGR TINKPKYPNI VDRDVIQMKH
LPDGTKQIVF KLDDLTSSKV VPTTKPELNQ IYVSVVQVLQ QRTNFETLSN QADHLISIAR
LLEAAYFGFQ IQDANDNSQE LFDKLAGLLV IKPLKSHDDP SDEIVQEKHT TIPHQFGHYA
SEEDFIEGKS TEKDVKTSKS SRVYARINTL EEIITITEDE EEEETDSSQP AGQARDQTST
FQENEIAEDE DEEFSQNDIV MDDESLPNDV HIEKSTMGPR IPSRVSPSKP KDSNTIIHAT
YHSEDETESK SQGEETGNTP ERDEL
//
