ID A0A210QQL5_MIZYE Unreviewed; 757 AA.
AC A0A210QQL5;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Serine/threonine-protein kinase tousled-like 2 {ECO:0000313|EMBL:OWF51025.1};
GN ORFNames=KP79_PYT19593 {ECO:0000313|EMBL:OWF51025.1};
OS Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Pectinida; Pectinoidea; Pectinidae;
OC Mizuhopecten.
OX NCBI_TaxID=6573 {ECO:0000313|EMBL:OWF51025.1, ECO:0000313|Proteomes:UP000242188};
RN [1] {ECO:0000313|Proteomes:UP000242188}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PY_sf001 {ECO:0000313|Proteomes:UP000242188};
RX PubMed=28812685; DOI=10.1038/s41559-017-0120;
RA Wang S., Zhang J., Jiao W., Li J., Xun X., Sun Y., Guo X., Huan P.,
RA Dong B., Zhang L., Hu X., Sun X., Wang J., Zhao C., Wang Y., Wang D.,
RA Huang X., Wang R., Lv J., Li Y., Zhang Z., Liu B., Lu W., Hui Y., Liang J.,
RA Zhou Z., Hou R., Li X., Liu Y., Li H., Ning X., Lin Y., Zhao L., Xing Q.,
RA Dou J., Li Y., Mao J., Guo H., Dou H., Li T., Mu C., Jiang W., Fu Q.,
RA Fu X., Miao Y., Liu J., Yu Q., Li R., Liao H., Li X., Kong Y., Jiang Z.,
RA Chourrout D., Li R., Bao Z.;
RT "Scallop genome provides insights into evolution of bilaterian karyotype
RT and development.";
RL Nat. Ecol. Evol. 1:120-120(2017).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWF51025.1}.
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DR EMBL; NEDP02002403; OWF51025.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A210QQL5; -.
DR STRING; 6573.A0A210QQL5; -.
DR EnsemblMetazoa; XM_021496757.1; XP_021352432.1; LOC110449715.
DR Proteomes; UP000242188; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd13990; STKc_TLK; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR22974; MIXED LINEAGE PROTEIN KINASE; 1.
DR PANTHER; PTHR22974:SF23; TOUSLED-LIKE KINASE, ISOFORM G; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:OWF51025.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000242188};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 395..673
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 38..155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 189..237
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 344..380
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 38..56
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..90
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..155
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 424
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 757 AA; 86636 MW; CAB047AE62E8763A CRC64;
MNTELTEAVN NSMENVNLQS LDPRKQELLE ARFYGSRFQP LNITQQQDNS NLSAGSAERD
DELIGVVHTP EKHARTPSER KRKRKATSEG TESNTPKSNR PEANGKKINE YFKQNQSPSR
SANSQSAGTK SPSPQGMSYS YTAPSPSNHS NSDSIGYPPV PLYHCNKTIQ TDLNLQQILV
LENKSSSHIE QKDSKIDDLL RQNDELRRQL TAQQKLIEKH KENLQKCLNV NKSLLIEKSK
LEKKTTRQKC MGDRLRLGQF VTQRQGATFV ENWVDGWAFT DLMKQQERIS SDREEIEKQR
KLLTKKKPTP TVMKNSKHDA FLKPGGDKPM TLAEFYEQDE ILKLRQASLK KEDADLQLEL
EKLERERNLH IRELKRIHNE DNSRFKEHPT LHDRYLLLCL LGKGGFSEVH KGFDLKEQRY
VACKIHQLNR EWKDDKKANY IKHALREYNI HKSLNHPRIV RLYDVFEIDN NSFCTVLEYC
EGNDLDFYLK QNKSIPEKEA RSIISQTVSA LRYLNEIKPP VIHYDLKPGN ILLGSGSVSG
EIKITDFGLS KVMDDDNLTP DGMDLTSQGA GTYWYLPPEC FVVGSNPPKI SSKVDVWSVG
VIFYQCLYGK KPFGHNLSQA AILEENTILK ATEVEFPAKP QISTEAKGFI RQCLQYKKEH
RPDVLLLAHQ DYLRPAPLKS KGHRCRSTNL PALRLGTEHD NSVLDVDPRE ITDLHLQFHV
LAEPRQLCMG QAPCSHVAVT NCLEVAQMDR RAPRQVP
//
