ID A0A210QU91_MIZYE Unreviewed; 1560 AA.
AC A0A210QU91;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=ATP-dependent RNA helicase YTHDC2 {ECO:0000313|EMBL:OWF52301.1};
GN ORFNames=KP79_PYT14885 {ECO:0000313|EMBL:OWF52301.1};
OS Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Pectinida; Pectinoidea; Pectinidae;
OC Mizuhopecten.
OX NCBI_TaxID=6573 {ECO:0000313|EMBL:OWF52301.1, ECO:0000313|Proteomes:UP000242188};
RN [1] {ECO:0000313|Proteomes:UP000242188}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PY_sf001 {ECO:0000313|Proteomes:UP000242188};
RX PubMed=28812685; DOI=10.1038/s41559-017-0120;
RA Wang S., Zhang J., Jiao W., Li J., Xun X., Sun Y., Guo X., Huan P.,
RA Dong B., Zhang L., Hu X., Sun X., Wang J., Zhao C., Wang Y., Wang D.,
RA Huang X., Wang R., Lv J., Li Y., Zhang Z., Liu B., Lu W., Hui Y., Liang J.,
RA Zhou Z., Hou R., Li X., Liu Y., Li H., Ning X., Lin Y., Zhao L., Xing Q.,
RA Dou J., Li Y., Mao J., Guo H., Dou H., Li T., Mu C., Jiang W., Fu Q.,
RA Fu X., Miao Y., Liu J., Yu Q., Li R., Liao H., Li X., Kong Y., Jiang Z.,
RA Chourrout D., Li R., Bao Z.;
RT "Scallop genome provides insights into evolution of bilaterian karyotype
RT and development.";
RL Nat. Ecol. Evol. 1:120-120(2017).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWF52301.1}.
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DR EMBL; NEDP02001843; OWF52301.1; -; Genomic_DNA.
DR STRING; 6573.A0A210QU91; -.
DR EnsemblMetazoa; XM_021493941.1; XP_021349616.1; LOC110447947.
DR OrthoDB; 1095660at2759; -.
DR Proteomes; UP000242188; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR CDD; cd18791; SF2_C_RHA; 1.
DR CDD; cd21134; YTH; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.10.590.10; ph1033 like domains; 1.
DR Gene3D; 3.30.1370.50; R3H-like domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001374; R3H_dom.
DR InterPro; IPR036867; R3H_dom_sf.
DR InterPro; IPR007275; YTH_domain.
DR PANTHER; PTHR18934:SF213; 3'-5' RNA HELICASE YTHDC2; 1.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR Pfam; PF01424; R3H; 1.
DR Pfam; PF04146; YTH; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00393; R3H; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF82708; R3H domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51061; R3H; 1.
DR PROSITE; PS50882; YTH; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000313|EMBL:OWF52301.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000242188};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 65..129
FT /note="R3H"
FT /evidence="ECO:0000259|PROSITE:PS51061"
FT DOMAIN 224..390
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT REPEAT 521..553
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 626..795
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1275..1405
FT /note="YTH"
FT /evidence="ECO:0000259|PROSITE:PS50882"
FT REGION 1..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 451..476
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1093..1113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1182..1270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1412..1560
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..47
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 458..474
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1215..1270
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1448..1520
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1546..1560
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1560 AA; 174079 MW; 31F0A80D9E5387D5 CRC64;
MAANLKYGRS ELPPGGSFAR VMQRGDGSSP RPSSTSSSQS FHSFASSEDY QDHGPRPGQD
ICIGEEVKIS IHLAMERFRM NESQKELEFP SSLTATERAY VHKLCEGNGL KSKSKGKASG
RYITITKREG RLSSQSSASF YLARNSRQQI LNLLQRYPVS NKERQELIPR VDRNQPSDVG
KELNKTTIGK LNNGVAQVPP PRGDSDLNAF REGLPVFKHR QDVLDALNNN RVILISGETG
SGKTTQVPQM ILDDCCNKNK PCRIFCTQPR RIAALSIAER VALERGEKIG QTVGYQIRLE
SKVSPKTLLT FCTNGVLLRT LMNGDASFGG VTHVIIDEVH ERDRFSDFLL ASMDELMTKH
PHLKIILMSA ALNTQLFVQF FNNCPVVHIP GTLFTVKEYF LEDVLKWTKY SNKAMEKAKR
EKGTVTKQQE QLEELCAKMS IGITYTEMED HSMAGKQSHS DTDSAPNNTN EDKSELPDWI
IKEMDQFLTD IFLMGSEETF AQLVHLIMSE NVSVDYQHSE TGVTPLMVTT ARGMNDEVEQ
LLNLGANVNL HLPNGWTAID WAKRFERNDI LEMLEALMLS NDVGPSGDSL AEAGNQLLTD
AEKDMLSLYQ SCFDDEKVDI QLILNLIYQL MSNYSDGAIL VFLPGYDDIV GLRDLIAEDS
FFHKYKYLLY TLHSAMQSND QRRVFKTPPP GVRKIILATN IAETSITIDD VVFVIDAGKV
KEKTFDALLS VTMLKSNWIS KASALQRKGR AGRVRPGLCY HLFSKVRYSN LMDFPAPEIL
RYPLQELCLH TKLLAPKTCS IADYLSKCPE PPTFLLTRNA IHLLKQIDAL DTCEDLTELG
HHLADLPVEP CLGKMVLYSV VLKCLDPVLT IVCTLAYKDP FVLPSQPNMK REASMSRRKF
AADTCSDHMA LLRAFQAWQR ARTDGWERSF CDKNYLSSAC MEMIVGMRTQ LLGQLRASGF
VRARGGGDIR DLNTNSENWA VVKAALCAGS YPNLLRVDRQ KARLATQKES NVFFHMSSVV
SQIPSSKKTQ KSQFIKSLRS DWLFYQEMTR FQRHPMVRTC TMVSPITVAV FAGPAKLSPD
AVKDRQLNRN FGMRGEFGSE ESDSEGEDKE DNRKTTLQLD EWLGFKLDNE TTSIVLQLRQ
KWNSLLLRRM RSPSKTWSQL DESVVRTIVN ILTNEEQTMG LQQPAGIGQR PRPMTAESIM
SGGGGKGNFD FVTPPRKNFQ FQQKSSSGVD TASSSSSNSP SANTSHRGSQ SSTPSMSPGP
ASPSVGVNHS SSQPTSFFVM KCNNQSKVDL SMNKGVWATN KSNNKKLNSV FQEGNTVYLV
FSVQGSGHFQ GYAKMKSEFV DKKVQDSSYH GLDYCCDVEW IKRANLSFQS TLQLLNPWDD
NRKVQTSRDG QEIEPHVGET LIKLWDKYLA HQGKSSPSAS NKPQNAGKRG AFHGPASPEG
PGSYQSIGGD HSDYSSHGTR NFYNRQSQGG YQDQGNYGGY QVNEGSHNGH RGQGQRGKSS
GRSPINQGNP FDNYSGYHTG GYQDNGVAPG TEYGSYSYHQ RGQGSGGHRR GNHNRSGNRR
//
