ID A0A210R1L7_MIZYE Unreviewed; 888 AA.
AC A0A210R1L7;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Guanine nucleotide exchange factor VAV2 {ECO:0000313|EMBL:OWF54918.1};
GN ORFNames=KP79_PYT03876 {ECO:0000313|EMBL:OWF54918.1};
OS Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Pectinida; Pectinoidea; Pectinidae;
OC Mizuhopecten.
OX NCBI_TaxID=6573 {ECO:0000313|EMBL:OWF54918.1, ECO:0000313|Proteomes:UP000242188};
RN [1] {ECO:0000313|Proteomes:UP000242188}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PY_sf001 {ECO:0000313|Proteomes:UP000242188};
RX PubMed=28812685; DOI=10.1038/s41559-017-0120;
RA Wang S., Zhang J., Jiao W., Li J., Xun X., Sun Y., Guo X., Huan P.,
RA Dong B., Zhang L., Hu X., Sun X., Wang J., Zhao C., Wang Y., Wang D.,
RA Huang X., Wang R., Lv J., Li Y., Zhang Z., Liu B., Lu W., Hui Y., Liang J.,
RA Zhou Z., Hou R., Li X., Liu Y., Li H., Ning X., Lin Y., Zhao L., Xing Q.,
RA Dou J., Li Y., Mao J., Guo H., Dou H., Li T., Mu C., Jiang W., Fu Q.,
RA Fu X., Miao Y., Liu J., Yu Q., Li R., Liao H., Li X., Kong Y., Jiang Z.,
RA Chourrout D., Li R., Bao Z.;
RT "Scallop genome provides insights into evolution of bilaterian karyotype
RT and development.";
RL Nat. Ecol. Evol. 1:120-120(2017).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWF54918.1}.
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DR EMBL; NEDP02000837; OWF54918.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A210R1L7; -.
DR STRING; 6573.A0A210R1L7; -.
DR Proteomes; UP000242188; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd20810; C1_VAV; 1.
DR CDD; cd21201; CH_VAV; 1.
DR CDD; cd01223; PH_Vav; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR037832; PH_Vav.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45818; PROTEIN VAV; 1.
DR PANTHER; PTHR45818:SF3; PROTEIN VAV; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00033; CH; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50002; SH3; 2.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022771};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000242188};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Zinc {ECO:0000256|ARBA:ARBA00022771};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 3..121
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 210..397
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 430..535
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 606..670
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 714..811
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 824..887
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 123..145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 888 AA; 101914 MW; BF47F0DACF926D4F CRC64;
MASEEWQQCA NWLIRCKILP EDHRATLPDA EIFDLAQALR DGVLICHLLN NLSPASVDVK
DFSPRPQLSQ FLCLKNIRTF LQTCKRVFGL RDADLFEPQD LFDVKDFRKV LMTLSRLSKT
DTAQSHYSGF PPNHRTHRAP PLPVADDDDE DIYGNLPRMA LENDLDDNEE IYDKVYQDDD
EEIYEDLCAR RHKRGSHPVT PSELPPPVTK LDYCVKEIHD TEKNYVDALT MLVQHFTKPL
RDVIPATDRD VIFAHIEKML EIHTALLVEL QQACQVACSV ATGSGSKIAE VFIKWKSKLL
VYGDYCSNLP KAQEKIDDIL KRNDTTVKAQ VETCEKRANE GKFKLRDLLH VPMQRVLKYH
LLLRELMRQT NKNSEDIRTL EAGLEAMMDL SLYVNEVKRD NETLSLIAEI QNSIGDLQMP
AQTSLKDYGR LQKDGELRVR AHTENKTKTR YIFLFDKVML MCKSKGETYN YKEAIILATF
KVDDSQLPKE TPVKRGDKWN TFSLVQKDNR TVYTFGAKTE DMRSRWIEAI KLALENTQPP
DHPNFVMHTF EKPTECYVCA KLLRGVFFQG YWNAEKKQGV HKECIGKERE RVPPIPPRVV
ETKESRRLSR VKALCDYIGQ PAPGAGRNVL SFRKNMLIDI INCTDPQWWK GKIEIVEGWF
PQHLVKEEKL TRKDSYVDVQ INENGRVTSP PRPHAQGGEG YVNIEDRGLT TYKWFVGNMQ
RETAIDRLKG LQNGTFLIRV SENPGRKGEL SLSIKYDNQV RHIRVERNAE NYFFLADTNF
FKSLPDLVEY YQHNSLKDSF PGVDTTLIHP FKSQTGGATG PGPRCLGYAV AVYDYAATAT
TQLSLSRGDR VAIFSKTGSD KGWWKGEHCG SHKVGYFPLA YVREEEDE
//