ID A0A210R699_MIZYE Unreviewed; 673 AA.
AC A0A210R699;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=Toll-like receptor 6 {ECO:0000313|EMBL:OWF56550.1};
GN ORFNames=KP79_PYT12026 {ECO:0000313|EMBL:OWF56550.1};
OS Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Pectinida; Pectinoidea; Pectinidae;
OC Mizuhopecten.
OX NCBI_TaxID=6573 {ECO:0000313|EMBL:OWF56550.1, ECO:0000313|Proteomes:UP000242188};
RN [1] {ECO:0000313|Proteomes:UP000242188}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PY_sf001 {ECO:0000313|Proteomes:UP000242188};
RX PubMed=28812685; DOI=10.1038/s41559-017-0120;
RA Wang S., Zhang J., Jiao W., Li J., Xun X., Sun Y., Guo X., Huan P.,
RA Dong B., Zhang L., Hu X., Sun X., Wang J., Zhao C., Wang Y., Wang D.,
RA Huang X., Wang R., Lv J., Li Y., Zhang Z., Liu B., Lu W., Hui Y., Liang J.,
RA Zhou Z., Hou R., Li X., Liu Y., Li H., Ning X., Lin Y., Zhao L., Xing Q.,
RA Dou J., Li Y., Mao J., Guo H., Dou H., Li T., Mu C., Jiang W., Fu Q.,
RA Fu X., Miao Y., Liu J., Yu Q., Li R., Liao H., Li X., Kong Y., Jiang Z.,
RA Chourrout D., Li R., Bao Z.;
RT "Scallop genome provides insights into evolution of bilaterian karyotype
RT and development.";
RL Nat. Ecol. Evol. 1:120-120(2017).
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWF56550.1}.
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DR EMBL; NEDP02000155; OWF56550.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A210R699; -.
DR STRING; 6573.A0A210R699; -.
DR EnsemblMetazoa; XM_021491176.1; XP_021346851.1; LOC110446164.
DR Proteomes; UP000242188; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365:SF541; MSTPROX-RELATED; 1.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF01582; TIR; 1.
DR SMART; SM00369; LRR_TYP; 6.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius}; Receptor {ECO:0000313|EMBL:OWF56550.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000242188};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 475..499
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 530..671
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 673 AA; 78068 MW; 2005F8E730EAFBE6 CRC64;
MSNLKTLDLS SLTGNCKIKS LTRGMFANVA VIQYLNMSFC KLTRIDTGAI SVLHRLMYLN
ISHNVYLSFS VLSNLTSDLR FTDIRTLDIS KIHCTYGVGT YLLVEDMKYL NDTKLEKLYI
NSNRISMLQS DTFNYLPPTV WYISTRDNLF TMGIYVLQIS VLNHLRELDV SDSFTTHNPD
EDTNRFHSCQ DWRGPQKHGT FLENDARLTN MVTLKRLGNA GKGLTFIVNL PRSLETVSMK
ACHYQYVISR LHFAENNLTH IFAQNNIFVE WRGPIINLTK LEYVDLSNNF CSYVANDFFR
YVPSLKTLIL HTNLLGFMIN RDRKGETFQN NTRITKLDIS LNRIDSLPRK IFHTLSSMQD
LNVSFNLMNS LQADIGHMMN LTYLDLSHNQ LSELTNQNRR DIDMITKTGN LTIDLSNNRL
VCSCLTLPSI RWINLNQRVF KRFETYSCSL DNETRVLFSD LDTTLRQLEK DCTSYIGLIG
GVLSAIVFCI AILVFGLVFR YRWKLRYLYY ITKNRYRGYA RVRDDQNHEF QFDAFISYAE
EESGFIKNDL ITNLEENRHF RLCVHGRDFI PGMDIAANIT NAIHSSRKTV VIMSENFIGS
YWCMYELNMA RMESIYSREG ATVLFLVMYN PVPAAVIPLH VMDIIRSKSY IEYPHDPQGN
VIFWEKIAES IEM
//
