ID A0A210R7I1_MIZYE Unreviewed; 2184 AA.
AC A0A210R7I1;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Myosin-VIIa {ECO:0000313|EMBL:OWF56826.1};
GN ORFNames=KP79_PYT20753 {ECO:0000313|EMBL:OWF56826.1};
OS Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Pectinida; Pectinoidea; Pectinidae;
OC Mizuhopecten.
OX NCBI_TaxID=6573 {ECO:0000313|EMBL:OWF56826.1, ECO:0000313|Proteomes:UP000242188};
RN [1] {ECO:0000313|Proteomes:UP000242188}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PY_sf001 {ECO:0000313|Proteomes:UP000242188};
RX PubMed=28812685; DOI=10.1038/s41559-017-0120;
RA Wang S., Zhang J., Jiao W., Li J., Xun X., Sun Y., Guo X., Huan P.,
RA Dong B., Zhang L., Hu X., Sun X., Wang J., Zhao C., Wang Y., Wang D.,
RA Huang X., Wang R., Lv J., Li Y., Zhang Z., Liu B., Lu W., Hui Y., Liang J.,
RA Zhou Z., Hou R., Li X., Liu Y., Li H., Ning X., Lin Y., Zhao L., Xing Q.,
RA Dou J., Li Y., Mao J., Guo H., Dou H., Li T., Mu C., Jiang W., Fu Q.,
RA Fu X., Miao Y., Liu J., Yu Q., Li R., Liao H., Li X., Kong Y., Jiang Z.,
RA Chourrout D., Li R., Bao Z.;
RT "Scallop genome provides insights into evolution of bilaterian karyotype
RT and development.";
RL Nat. Ecol. Evol. 1:120-120(2017).
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWF56826.1}.
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DR EMBL; NEDP02000041; OWF56826.1; -; Genomic_DNA.
DR STRING; 6573.A0A210R7I1; -.
DR Proteomes; UP000242188; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0120025; C:plasma membrane bounded cell projection; IEA:UniProt.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd17092; FERM1_F1_Myosin-VII; 1.
DR CDD; cd17093; FERM2_F1_Myosin-VII; 1.
DR CDD; cd14473; FERM_B-lobe; 2.
DR CDD; cd13198; FERM_C1_MyoVII; 1.
DR CDD; cd13199; FERM_C2_MyoVII; 1.
DR CDD; cd01381; MYSc_Myo7; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 1.20.80.10; -; 2.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR041793; MyoVII_FERM_C1.
DR InterPro; IPR041794; MyoVII_FERM_C2.
DR InterPro; IPR036106; MYSc_Myo7.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR22692:SF33; MYOSIN; 1.
DR PANTHER; PTHR22692; MYOSIN VII, XV; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF00612; IQ; 3.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF00784; MyTH4; 2.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00295; B41; 2.
DR SMART; SM00015; IQ; 4.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00139; MyTH4; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 2.
DR PROSITE; PS50057; FERM_3; 2.
DR PROSITE; PS50096; IQ; 2.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51016; MYTH4; 2.
DR PROSITE; PS01179; PID; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Coiled coil {ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000242188};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 68..741
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 1018..1260
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1265..1572
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 1570..1638
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1714..1862
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1868..2171
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 2097..2124
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT REGION 620..642
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT COILED 866..924
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 161..168
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 2184 AA; 252314 MW; 66ABE773592CB7F8 CRC64;
MVSIYPHMQV RGDHVWLEPE TKGEFTVAIG ARVKFHDSGR VHVVDDDGNE HWLDGKQKIR
HMHSHSVEGV EDMIGLGDLN EAGILRNLFI RYMDNLIYTY TGSIMVAVNP YQILPIYTAE
QIQAYRDKKI GERPPHIFAI ADNSYFNMRR YQRDQCVIIS GESGAGKTES TKLILQFLAA
VSGQHSWIEQ QILEANPIME AFGNAKTIRN DNSSRFGKYI DIHFNDKGTI EGAKIEQYLL
EKSRIVTQAH DERNYHIFYC MLVGMTKEEK QKLDVGSATD YWYLTQGGSI FCDGRDDTKE
FADIRSAMKV LMFQDKEVWE ILKILASLLH LGNIKYNAIE MDNMDATEIQ DIQSVNKAAK
LMEVRAQDLI DALTTRSIVT QGEIVTTMMS VGNSQDVRDA FVKGIYGRMF IWIVQKINFA
IFKPKTAPNH FRTSIGVLDI FGFESFDHNS FEQLCINYAN ENLQQFFVRH IFKLEQEEYD
NEGINWQHIE FVDNQDALDL IGAKAMNIIS LVDEESKFPK GSDQTMLAKL HQQHKDNRNY
LRPKAEITHV FGLNHFAGVV FYDAKGFLEK NRDTFSPDLL QLIQTSSNPF LAGLFTQDIT
MGADTRKRAP TLGSQFKKSL ELLMRTLGAC QPFFVRCIKP NELKKPLIFD RELCCKQLRY
SGMMETIRIR RAGYPIRHRF NDFVDRYRLL ASGIGPSHKE NCRQASEKIC EVVLGGKDYQ
MGKTKVFLKD AQDVYLEQQR ELALTAKILI LQKTIRAWHC RRKFLKIKTG SILIQKMWRQ
YLERKRFLLM KQGYMRLQAV VRSRLLTAQF NRKRAVIIDL QRRCRGYLVR KWTMQRMISI
VKIQAVVRAM IARRKYKRQK IEYHNKMELE HLRKEEEGKL KRKMNDKKAK MEAERLYQER
LREMERKVEE EESMEKNMAI QKKEQIEIAE RRKNEPVSDS KLVEEMFGFI DGNTDDGAAP
YSFKDLEDKR RRIAHENGIE DYSSLMEPEL PEDDEDLTEY KFSKFASMYF QANTPHTFIR
KALREPLLPM KNDGDKLAAL AVWITILRFM GDLPEPKYTA MAQDSRDTTP VMTKIYSTLG
RKFNKKDLEE AQRMGLDIEK EPYPMGRAGK RSMRKKLVSL TLKKKSKITE EVTRKLMADF
DGSYGSNALL EERPTSNLEK LHLIIGHGIL RPELRDEIYS QICKQLTQNP TKSSHARGWI
LLSLCVGCFA PTDKFLKYLR NFIHEGPPGY APYCESRLRR TFANGTRNQP PSWLELQATK
SKKPLMLPIT FMDGNTKTLL ADSATTAKEL CMQLSEKIVL KDQFGFSLYI ALFDKVSSLG
SGGDHVMDAI SQCEQYAKEQ GAQERNAPWR LFFRKEIFAP WHNPGEDTTA SNLIFQQVVR
GIKFGEYRCD KDDDLAMIAA QQYYIEYGCN ANPERLQSLL PSYVPDSSLQ KPNATGFWIN
MIMTKLRIPY FERIKPVKVK EDIVSYAKYK WPLLFSRFYE AYKFAGPSLP KNDVIIAVNW
TGVYIVDDQE QVLLELSFPE ITAVSSSRTG KMHGQSFTLA TVKGDEYTFT SPNAEDIRDL
VVTFLEGLKK RSKYVIALQD YTSPGDGSSF LDFTKGDLIV LDQQNGETVM NSGWCVGENV
RTNVKGDFPA ECVYVLPTIN KPPPEILNLF LQSGEQADRM LAPTQVDNVP DTGTDVPYTL
EHYSYDHFRP PPKRTLSKTL STARKRRPDE LWRHSKEPLK QPLLKKLLGK EELCQEACMC
FLDILFFYSL PINAIALTAN ELTDQIYEPP LRNELLRDEI YCQMIKQLTN NRNETSERRG
WELMWLATGC FIPSTNLLKE VMQFLRSSRS HIATDCISRV QKTLRNGTRK YAPHQVEVEA
IQHKTTQILH KVYFPDDSDE AFEVESSTRA KDFCQNIANK LRLKSSEGFS LFVKIVDKVI
SVPEGDFFFD FVRHLTDWIR KARPSRDGTV PQFTYQVFFM KKLWSNTMPG RDIQADRIFH
YHQELPKLLR GYHKCSKDEA AQMAALIYRV KCGDNKSSLA NIPRMLRELI PADLVRVQSP
EDWKRAIVNY FNRDSQRTLE DPKVEFLKII YKWPTFGSAF FEVKQATEPT YPDVLLIAIN
KNGVNLINQQ TKDILATHPF TKISNWSSGN TYFHMTIGNL VRGSKLLCET SLVEFDKNFI
MKNFNIIVKF KSLGNLRNMT PCDT
//
