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Database: UniProt
Entry: A0A210RVU5_9BURK
LinkDB: A0A210RVU5_9BURK
Original site: A0A210RVU5_9BURK 
ID   A0A210RVU5_9BURK        Unreviewed;       454 AA.
AC   A0A210RVU5;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   16-JAN-2019, entry version 12.
DE   RecName: Full=UDP-glucose 6-dehydrogenase {ECO:0000256|PIRNR:PIRNR000124};
DE            EC=1.1.1.22 {ECO:0000256|PIRNR:PIRNR000124};
GN   ORFNames=B6A14_04405 {ECO:0000313|EMBL:OWF65060.1};
OS   Polynucleobacter hirudinilacicola.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Polynucleobacter.
OX   NCBI_TaxID=1743166 {ECO:0000313|EMBL:OWF65060.1, ECO:0000313|Proteomes:UP000196880};
RN   [1] {ECO:0000313|EMBL:OWF65060.1, ECO:0000313|Proteomes:UP000196880}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MWH-EgelM1-30-B4 {ECO:0000313|EMBL:OWF65060.1,
RC   ECO:0000313|Proteomes:UP000196880};
RA   Hahn M.W.;
RT   "New species Polynucleobacter sp. MWH-EgelM1-30-B4.";
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH +
CC         UDP-alpha-D-glucuronate; Xref=Rhea:RHEA:23596,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945, ChEBI:CHEBI:58052, ChEBI:CHEBI:58885;
CC         EC=1.1.1.22; Evidence={ECO:0000256|PIRNR:PIRNR000124};
CC   -!- SIMILARITY: Belongs to the UDP-glucose/GDP-mannose dehydrogenase
CC       family. {ECO:0000256|PIRNR:PIRNR000124}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OWF65060.1}.
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DR   EMBL; NAIA01000003; OWF65060.1; -; Genomic_DNA.
DR   Proteomes; UP000196880; Unassembled WGS sequence.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0003979; F:UDP-glucose 6-dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR017476; UDP-Glc/GDP-Man.
DR   InterPro; IPR014027; UDP-Glc/GDP-Man_DH_C.
DR   InterPro; IPR036220; UDP-Glc/GDP-Man_DH_C_sf.
DR   InterPro; IPR014026; UDP-Glc/GDP-Man_DH_dimer.
DR   InterPro; IPR001732; UDP-Glc/GDP-Man_DH_N.
DR   InterPro; IPR028357; UDPglc_DH_bac.
DR   Pfam; PF00984; UDPG_MGDP_dh; 1.
DR   Pfam; PF03720; UDPG_MGDP_dh_C; 1.
DR   Pfam; PF03721; UDPG_MGDP_dh_N; 1.
DR   PIRSF; PIRSF500134; UDPglc_DH_bac; 1.
DR   PIRSF; PIRSF000124; UDPglc_GDPman_dh; 1.
DR   SMART; SM00984; UDPG_MGDP_dh_C; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52413; SSF52413; 1.
DR   TIGRFAMs; TIGR03026; NDP-sugDHase; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000196880};
KW   NAD {ECO:0000256|PIRNR:PIRNR000124, ECO:0000256|PIRSR:PIRSR500134-3};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR000124}.
FT   DOMAIN      325    437       UDPG_MGDP_dh_C. {ECO:0000259|SMART:
FT                                SM00984}.
FT   ACT_SITE    271    271       Nucleophile. {ECO:0000256|PIRSR:
FT                                PIRSR500134-1}.
FT   BINDING      30     30       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING      35     35       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING      86     86       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     121    121       NAD; via amide nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     159    159       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     274    274       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     339    339       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
SQ   SEQUENCE   454 AA;  49809 MW;  6D0D37A8B8D4CE17 CRC64;
     MKVTIIGSGY VGLVTGACLA EQGNNVFCLD LDPKKIDILN SGGVPIYEPG LKEMIERNRA
     AGRLQFSTDI AASVAHGDIQ FIAVGTPPDE DGSADLQYVV AAARNIGRHA TTPKVIVDKS
     TVPVGTADKV SAAIKEELEK RGQPADLCSV VSNPEFLKEG AAVEDFMRPD RIVIGTENTP
     AGLRAKEQMR KLYAPFNRHH ERTYYMDVKS AELTKYAANA MLATRISFMN ELANLADLVG
     ADIEAVRQGI GSDSRIGYGF LYSGTGYGGS CFPKDVSALS KTAREHGRDL KILDAVEAVN
     ELQKYILVEK IEKRFGQDLQ GMKFALWGLA FKPNTDDMRE APSRVIIQEL VKRGASVVAH
     DPVAMKEAQH YLEIDFKGNP EGLQKVSMVD NPMAALDCCD ALVIVTEWKA FRSPDFEQVM
     QKLTRPIIFD GRNLYEPSAM QELGIEYYGI GRHN
//
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