ID A0A212C650_CEREH Unreviewed; 444 AA.
AC A0A212C650;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 22-FEB-2023, entry version 16.
DE RecName: Full=Connexin N-terminal domain-containing protein {ECO:0000259|SMART:SM00037};
GN ORFNames=Celaphus_00018957 {ECO:0000313|EMBL:OWK01460.1};
OS Cervus elaphus hippelaphus (European red deer).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Cervidae;
OC Cervinae; Cervus.
OX NCBI_TaxID=46360 {ECO:0000313|EMBL:OWK01460.1, ECO:0000313|Proteomes:UP000242450};
RN [1] {ECO:0000313|Proteomes:UP000242450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=29294181;
RA Bana N.A., Nyiri A., Nagy J., Frank K., Nagy T., Steger V., Schiller M.,
RA Lakatos P., Sugar L., Horn P., Barta E., Orosz L.;
RT "The red deer Cervus elaphus genome CerEla1.0: sequencing, annotating,
RT genes, and chromosomes.";
RL Mol. Genet. Genomics 293:665-684(2018).
CC -!- SUBCELLULAR LOCATION: Cell junction, gap junction
CC {ECO:0000256|ARBA:ARBA00004610}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWK01460.1}.
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DR EMBL; MKHE01000028; OWK01460.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A212C650; -.
DR Proteomes; UP000242450; Chromosome 28.
DR GO; GO:0005922; C:connexin complex; IEA:InterPro.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR Gene3D; 1.20.1440.80; Gap junction channel protein cysteine-rich domain; 2.
DR InterPro; IPR000500; Connexin.
DR InterPro; IPR017990; Connexin_CS.
DR InterPro; IPR013092; Connexin_N.
DR InterPro; IPR038359; Connexin_N_sf.
DR PANTHER; PTHR11984; CONNEXIN; 1.
DR PANTHER; PTHR11984:SF9; GAP JUNCTION ALPHA-10 PROTEIN; 1.
DR Pfam; PF00029; Connexin; 1.
DR PRINTS; PR00206; CONNEXIN.
DR SMART; SM00037; CNX; 1.
DR PROSITE; PS00407; CONNEXINS_1; 1.
PE 4: Predicted;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Gap junction {ECO:0000256|ARBA:ARBA00022868};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000242450};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 24..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 78..100
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 149..174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 43..76
FT /note="Connexin N-terminal"
FT /evidence="ECO:0000259|SMART:SM00037"
FT REGION 186..205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 265..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 382..422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 100..148
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 186..200
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..303
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 342..366
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 384..403
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 444 AA; 51084 MW; 8E4A93CBF50DA58C CRC64;
MGDWNLLGGI LEEVHSHSTM VGKIWLTILF IFRMLILGVA AEDVWDDEQS AFACNTQQPG
CNTVCYDDAF PISLIRFWVL QIIFVSSPSL VYMGHALYRL RAFEKERQRK KSQLRAQMEN
PELELEDQQR MDRELRKLEE QKRIQKKTIF MLFMHSIAAI SLFLNILEIF HLGIRKIIKT
LYDKSSSEGI EDDRRPPSHV KKHSVTQQCM TCSPFPEKIS LLQANNQQQV IRVNVPNSKT
TWHIPQPRQL DVDPCYSKKD WAEKNQHNGQ LHVHSPCPWD DGARIQHPGQ QPDQSSFGLQ
TVRPHSWLGT RMAPRHCPPH TTGPWEQSQD RQPSGGPLAD LHSHCRHSDG SRRDSRVQEA
RDRSYPSSRK ASFLSRLFSE KGQLYGDSGS SSSPNSSCQG FPRRENSPPL LPSDPGRRTS
MVRKVRQPDW SWNFHKRCPP LVPS
//
