ID A0A212EKD3_DANPL Unreviewed; 1687 AA.
AC A0A212EKD3;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Otoferlin {ECO:0000313|EMBL:OWR41972.1};
GN ORFNames=KGM_203021 {ECO:0000313|EMBL:OWR41972.1};
OS Danaus plexippus plexippus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Nymphalidae; Danainae; Danaini; Danaina; Danaus; Danaus.
OX NCBI_TaxID=278856 {ECO:0000313|EMBL:OWR41972.1, ECO:0000313|Proteomes:UP000007151};
RN [1] {ECO:0000313|EMBL:OWR41972.1, ECO:0000313|Proteomes:UP000007151}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F-2 {ECO:0000313|EMBL:OWR41972.1};
RX PubMed=22118469; DOI=10.1016/j.cell.2011.09.052;
RA Zhan S., Merlin C., Boore J.L., Reppert S.M.;
RT "The monarch butterfly genome yields insights into long-distance
RT migration.";
RL Cell 147:1171-1185(2011).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWR41972.1}.
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DR EMBL; AGBW02014274; OWR41972.1; -; Genomic_DNA.
DR STRING; 278856.A0A212EKD3; -.
DR KEGG; dpl:KGM_203021; -.
DR eggNOG; KOG1326; Eukaryota.
DR InParanoid; A0A212EKD3; -.
DR Proteomes; UP000007151; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd04018; C2C_Ferlin; 1.
DR CDD; cd04017; C2D_Ferlin; 1.
DR CDD; cd04037; C2E_Ferlin; 1.
DR CDD; cd08374; C2F_Ferlin; 1.
DR Gene3D; 2.60.40.150; C2 domain; 4.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037722; C2C_Ferlin.
DR InterPro; IPR037723; C2D_Ferlin.
DR InterPro; IPR037724; C2E_Ferlin.
DR InterPro; IPR037725; C2F_Ferlin.
DR InterPro; IPR012968; FerIin_dom.
DR InterPro; IPR037721; Ferlin.
DR InterPro; IPR012561; Ferlin_B-domain.
DR InterPro; IPR032362; Ferlin_C.
DR PANTHER; PTHR12546; FER-1-LIKE; 1.
DR PANTHER; PTHR12546:SF60; MISFIRE, ISOFORM F; 1.
DR Pfam; PF00168; C2; 4.
DR Pfam; PF08150; FerB; 1.
DR Pfam; PF08151; FerI; 1.
DR Pfam; PF16165; Ferlin_C; 1.
DR SMART; SM00239; C2; 4.
DR SMART; SM01201; FerB; 1.
DR SMART; SM01202; FerI; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 5.
DR PROSITE; PS50004; C2; 5.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007151};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1656..1676
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 87..222
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 623..755
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 800..931
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1167..1285
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1407..1554
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 991..1010
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1032..1093
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1056..1075
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1687 AA; 193754 MW; 2C655087F3951E1D CRC64;
MGKFFMIIGN SFVLQSRNIL RTNKLLGTFK LDVATVWNQP GRQFYHKWAM LTDPDDVSAG
PKGYLKCDIS VIGKGDTVKV PPRSEKDEDN IEANLLLPDG MPVERQRARF FIKIYKADGL
PKMNYSLLAN VRKAFTGESQ DLVDPYVEVS FAGMTGCTSV KKNSYSPVWN EQIVFTEMFP
PLCQRLKIQL KDDDAVHPGI IGTHFIDLQT ISHEGDRGFL PTFGPAYIHM YGSTRDYSLL
DQHANLNTGI GEGVSYRARL LIAIRTEIME IIENPSLDVE IEPIVAVNEH AYEKHEEFFL
FACLFDVNMI DKRLTDKPIQ FELSIGNTGN VLDGNKESLR RPQDLNAPDL NDLSADTGFW
QSVSQPTKAV SSDKNYYYLP YWDLKQCMHV RSIWPDHRRR MYNSNMIYKI IEQFEEGLDN
AQNAVESDDG PDNSCVAYLK SVLDSVTASC INYLDHMSDL PIGGGTKLDR ERHKLCLREI
EQMSTLTKSL KAVVTKHSIK DRIRTAYGYL NRLKHLCEDP QHAMPDIFIW MISNGKRLAY
HRFSVRDLIF SESMEERGKL CGKMQTIFLK WPGKKATSPS GWSIPAKINV FLWLGTLQDK
KHFLETLPIG YELSQEVKNA DKPRALAPET LFYAEKHNFQ MRAYIYQARS LIGSDSSGLS
DPFARVVLGD ASATTQVIEE TLSPTWDELL VLDEILLYST IENIKADPPT IVIEIFDQDK
VGKSEFIGRT LAKPTVRSCE DLLTGLQQPP ILEWHEITRG DDKAGELLAT FEILELPPKG
DGNESALPTL PDPKDVVRKD LNETQRSISY PVPRGIRPTL SRYRVEVLFW GLREVKRLHL
LTVDRPRVDI ECAGNLVYSS VIQNASRNPN FPFPIKYIDV ELPDQDLYRP PLTIRVVDCR
SFGRITLVGT HTINSIHKYI YTPMSKRERE IEERKKSIIE LQNVDLRTNR IIQDDAYAVE
TERENCPLLV REGRSMTYGS GIKMPMRKKI LPRDVSKKRK GSNDSVLDDD ESNKDWWTKY
FASVETMIED EKENKRERDY LRPPQISYIN ELRSPREELG SPRFDRDRRR DPQPSTSSRS
KTGPLVAPKN EIPRSAMTKV YPHELEAVPE YEEFKEWLNS FELYRGKKTG DDSEDDNRVV
GVFKGAIKVY KWPLPRGIDD HTIMGFDPSN GFFQGVPNND PIHVLVRVYI VKATDLHPMD
INGKADPYIS LQLGSKKISD KENYVSKQLN PVFGKCFEIE ATFPQDSNLT IQVLDWDLVG
SDDLIGETKI DLENRFYSRH RATCGLPMKY EEQGYNRWRD AMKPTQILAK LCKDGKLDPP
VYDYGRVKIG KTIFNMPMND EELFSNNDTA EEQMALVVLH RWHEVPRVGT RLVTEHVETR
SLYKPNKPGI EQGRLEMWVD MFPMDMPLPG PPVDISARKP KSFEMRVIVW NTDDVVLEDD
AFFTGEKMSD IYVKGWVRGP DDCQSTDIHY RSLTGEGNFN WRFIYPFEYL EAEERIVISR
KESVFSWDET ECKIPARLEL QVWDADHFSA DDFLGAITLD LNRFPRGAKT SKLCTLDMLR
NDGSVPMVNI FKQKRVKGWW PFYIKRDTEE MELTGKVEAE IHLLTKEEAE KVPAGLGRSE
PDPLEKPNRP DASFMWLLNP LKSIRYIMWH NHKWDILKYS FIIIVAVMIL LLVYAVPGYT
IKRLLGA
//
