ID   A0A212ES14_DANPL        Unreviewed;       612 AA.
AC   A0A212ES14;
DT   27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT   27-SEP-2017, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=Ionotropic receptor 40a {ECO:0008006|Google:ProtNLM};
GN   ORFNames=KGM_205826 {ECO:0000313|EMBL:OWR44288.1};
OS   Danaus plexippus plexippus.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC   Nymphalidae; Danainae; Danaini; Danaina; Danaus; Danaus.
OX   NCBI_TaxID=278856 {ECO:0000313|EMBL:OWR44288.1, ECO:0000313|Proteomes:UP000007151};
RN   [1] {ECO:0000313|EMBL:OWR44288.1, ECO:0000313|Proteomes:UP000007151}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F-2 {ECO:0000313|EMBL:OWR44288.1};
RX   PubMed=22118469; DOI=10.1016/j.cell.2011.09.052;
RA   Zhan S., Merlin C., Boore J.L., Reppert S.M.;
RT   "The monarch butterfly genome yields insights into long-distance
RT   migration.";
RL   Cell 147:1171-1185(2011).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC       family. {ECO:0000256|ARBA:ARBA00008685}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OWR44288.1}.
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DR   EMBL; AGBW02012888; OWR44288.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A212ES14; -.
DR   STRING; 278856.A0A212ES14; -.
DR   KEGG; dpl:KGM_205826; -.
DR   eggNOG; KOG2510; Eukaryota.
DR   InParanoid; A0A212ES14; -.
DR   Proteomes; UP000007151; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR   GO; GO:0050906; P:detection of stimulus involved in sensory perception; IEA:UniProt.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 1.
DR   InterPro; IPR019594; Glu/Gly-bd.
DR   InterPro; IPR001320; Iontro_rcpt_C.
DR   PANTHER; PTHR42643; IONOTROPIC RECEPTOR 20A-RELATED; 1.
DR   PANTHER; PTHR42643:SF40; IONOTROPIC RECEPTOR 40A; 1.
DR   Pfam; PF00060; Lig_chan; 1.
DR   Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR   SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007151};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        384..409
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        448..467
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          259..353
FT                   /note="Ionotropic glutamate receptor L-glutamate and
FT                   glycine-binding"
FT                   /evidence="ECO:0000259|Pfam:PF10613"
FT   DOMAIN          382..489
FT                   /note="Ionotropic glutamate receptor C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00060"
SQ   SEQUENCE   612 AA;  70227 MW;  3A00908AD94E5E00 CRC64;
     MSRDVPQAIV PELPKRNEFQ NPTSSIRPSR YLNYNQDTNM ILTYIILLCV RDTQCLFEVR
     DSVDVNLKQL PKDFSKAVVD IAIGLPTNTI TVVRGNSTDV RDADIFELFC SLGDNNIQVT
     NLDLMTPESK DIYYKYLKEG LDNSEERTSL ILCKPKECED LLLEVTSNNF IHRPILYIFF
     WSEDEVPKNF TTCIKEAVRV AVITNPRKGV FRLYYNQANP NKPRHLKLVN WWAGQLYKSP
     SLPPANKVYE DFQGRILNVP VLHAPPWHFV RYMNDSTVNV TGGRDHKLLS LLAKKLNFKY
     KYYDPPERSQ GSRISGNGTF KGTLGQIWQR KADFFIGDVT MTWERLQAVE FSFLTLADSG
     AFLTHAPDKL SETLAIIRPF RWEVWPLVFA TILVTGPALW VVIATPYIWQ RRERDQMELL
     NNCCWFTTSL FLRQTTRKEP STSNKARLVS ILISLGATYV IGDMYSANLT SLMARPSKEQ
     AIGTLVALEE AMRNDGYELV VESHSSSLAI LQNGTDIYGR LARLMRRQRT QRVKSVEVGV
     NMVLSKRRIA ILGGRETLFY DTERFGSHNF HLSEKLYTRY SAIALQIGCP YLETFNNVNH
     ISNQTQENLS DY
//