ID A0A212EVE6_DANPL Unreviewed; 1202 AA.
AC A0A212EVE6;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Putative toll {ECO:0000313|EMBL:OWR45424.1};
GN ORFNames=KGM_205279 {ECO:0000313|EMBL:OWR45424.1};
OS Danaus plexippus plexippus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Nymphalidae; Danainae; Danaini; Danaina; Danaus; Danaus.
OX NCBI_TaxID=278856 {ECO:0000313|EMBL:OWR45424.1, ECO:0000313|Proteomes:UP000007151};
RN [1] {ECO:0000313|EMBL:OWR45424.1, ECO:0000313|Proteomes:UP000007151}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F-2 {ECO:0000313|EMBL:OWR45424.1};
RX PubMed=22118469; DOI=10.1016/j.cell.2011.09.052;
RA Zhan S., Merlin C., Boore J.L., Reppert S.M.;
RT "The monarch butterfly genome yields insights into long-distance
RT migration.";
RL Cell 147:1171-1185(2011).
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWR45424.1}.
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DR EMBL; AGBW02012218; OWR45424.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A212EVE6; -.
DR STRING; 278856.A0A212EVE6; -.
DR KEGG; dpl:KGM_205279; -.
DR eggNOG; KOG4641; Eukaryota.
DR InParanoid; A0A212EVE6; -.
DR Proteomes; UP000007151; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 6.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR026906; LRR_5.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24373; SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN; 1.
DR PANTHER; PTHR24373:SF275; VASORIN; 1.
DR Pfam; PF13306; LRR_5; 1.
DR Pfam; PF13855; LRR_8; 5.
DR Pfam; PF01582; TIR; 1.
DR SMART; SM00365; LRR_SD22; 10.
DR SMART; SM00369; LRR_TYP; 20.
DR SMART; SM00082; LRRCT; 2.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52047; RNI-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 8.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007151};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 862..886
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 916..1061
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 1114..1202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1114..1135
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1136..1163
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1169..1187
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1202 AA; 136956 MW; D6FC9BB09AAFE6D2 CRC64;
MSMEFHRDSF RGLTDLRTLD LGDNNIWILP SEIFCPLYNL KELNITLNRL QDISNLGFSD
WGNGPTAPGK SCNTVLETLD MSFNEISALP DNGLSSLRAL QRLLLQNNRI STVADRAFVG
LSDLQMLNLS TNALTALPPE MFQSSRDIKQ IYLNNNSLSV LAPGLLEGLD QLQILDLSYN
ELTSEWVNRD TFSGLVRLIV LNLSHNRITK IDALLFQDLN NLQFLSLEYN NVARIADGAF
SYLKNLHSLS LAHNNIVEVD SNHFSNLYVL NQLFLDGNRI TKVDLRSFEN ITKLHDLGLS
GNQLSEVPEA IKTLRFLTAL DLGMNRITKV TTNLFEGLDD LFGLRLVGNK IEKISKDTFA
ALPSLQILNL ASNNIDQIDD GAFASNLQLR AIVLDGNKLV DLKGIFTKTQ PLVWLNVSNN
ELLWFDYSHI PTNLEWLDMH ENKIEKLEDT YGVKETCNVK MLDVSNNKIR NIDEFSFPSS
IETVVLNNNN IEKINPGTFL QKYNLNKVML YSNKIKTLDV GAFAISFVPE DRDLPEFYIS
ENPFECDCTM EWLQRINQLS ELRQRPRVMD LENVRCSLTH SRSSSDVLLL EVKSFEFLCE
YESHCFTLCH CCDFDACDCK MTCPDKCSCY HDLTWSSNVV DCSSGGYDHV PDQIPMDATE
IYLDGNDLKE LGNHVFIGKK RLQVLYLNNS NINLIQNKTF NGIESLRVLH LENNKLEVLR
NTQFTKLQNL NELYLQDNNI RFIENDTFNY LPSLEYLSLD NNGYVEYMPW RVITDNNPRT
RVSVEGNNWI CDCKDVAQLN QWLIKKSKDT DNMMCFFAHG QPMNKTIATV SKECKAETTT
EETGTETQKR LFIESNDSVE NYIPYIVAGL ITVTVLLLMC AFLFMFRDDF KLWMHSKYGI
RVFSSASKDV NDNKNKRFAA FFMYNPQDEG VMRVVSSELE QLGHTLCLQH RDLQLIERRS
SDNLVSAAES SKRLIIVLST SFLEQEWDMP ASKAAVQCAI NSVNVRHRRQ KIIFLVTTDL
SAISIDPDLK VLLKTCTVIL WGEKYCLEKL NFWLPDVDVT LPNRTIHNAN NIKTGNREGF
GRHVNLRYTA PPTSHDSWYK YGMDRQMSIM SSPMHSTSAS AEVSARSTED ETCSVASSEG
RPDDRLPHHH SYVSIDNHPC EERPLRPAQQ IAMSNTRPTN SPRQCARAAN PLRNYKSSLD
AG
//
