UniProt: A0A212EW68

Database: UniProt
Entry: A0A212EW68_DANPL

LinkDB:  A0A212EW68_DANPL 
Original site:  A0A212EW68_DANPL

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Ontology (3)   
   GO (3)   
Gene (1)   
   KEGG GENES (1)   
Protein sequence (4)   
   RefSeq(pep) (4)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (3)   
   InterPro (1)   
   Pfam (1)   
   PROSITE (1)   
Literature (1)   
   PubMed (1)   
All databases (13)   

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ID   A0A212EW68_DANPL        Unreviewed;       373 AA.
AC   A0A212EW68;
DT   27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT   27-SEP-2017, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=Innexin {ECO:0000256|RuleBase:RU010713};
GN   Name=LOC116765363 {ECO:0000313|RefSeq:XP_032510719.1,
GN   ECO:0000313|RefSeq:XP_032510727.1, ECO:0000313|RefSeq:XP_032510734.1,
GN   ECO:0000313|RefSeq:XP_032510743.1};
GN   Synonyms=inx {ECO:0000256|RuleBase:RU010713};
GN   ORFNames=KGM_215317 {ECO:0000313|EMBL:OWR45726.1};
OS   Danaus plexippus plexippus.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC   Nymphalidae; Danainae; Danaini; Danaina; Danaus; Danaus.
OX   NCBI_TaxID=278856 {ECO:0000313|EMBL:OWR45726.1, ECO:0000313|Proteomes:UP000007151};
RN   [1] {ECO:0000313|EMBL:OWR45726.1, ECO:0000313|Proteomes:UP000007151}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F-2 {ECO:0000313|EMBL:OWR45726.1};
RX   PubMed=22118469; DOI=10.1016/j.cell.2011.09.052;
RA   Zhan S., Merlin C., Boore J.L., Reppert S.M.;
RT   "The monarch butterfly genome yields insights into long-distance
RT   migration.";
RL   Cell 147:1171-1185(2011).
RN   [2] {ECO:0000313|EMBL:OWR45726.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=F-2 {ECO:0000313|EMBL:OWR45726.1};
RA   Zhan S., Reppert S.M.;
RT   "MonarchBase: the monarch butterfly genome database.";
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|RefSeq:XP_032510719.1, ECO:0000313|RefSeq:XP_032510727.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Structural component of the gap junctions.
CC       {ECO:0000256|RuleBase:RU010713}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU010713};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU010713}. Cell
CC       junction, gap junction {ECO:0000256|RuleBase:RU010713}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the pannexin family. {ECO:0000256|PROSITE-
CC       ProRule:PRU00351, ECO:0000256|RuleBase:RU010713}.
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DR   EMBL; AGBW02012071; OWR45726.1; -; Genomic_DNA.
DR   RefSeq; XP_032510719.1; XM_032654828.1.
DR   RefSeq; XP_032510727.1; XM_032654836.1.
DR   RefSeq; XP_032510734.1; XM_032654843.1.
DR   RefSeq; XP_032510743.1; XM_032654852.1.
DR   STRING; 278856.A0A212EW68; -.
DR   EnsemblMetazoa; XM_032654828.1; XP_032510719.1; LOC116765363.
DR   EnsemblMetazoa; XM_032654836.1; XP_032510727.1; LOC116765363.
DR   EnsemblMetazoa; XM_032654843.1; XP_032510734.1; LOC116765363.
DR   EnsemblMetazoa; XM_032654852.1; XP_032510743.1; LOC116765363.
DR   KEGG; dpl:KGM_215317; -.
DR   eggNOG; ENOG502QWRS; Eukaryota.
DR   OrthoDB; 2873211at2759; -.
DR   Proteomes; UP000007151; Unassembled WGS sequence.
DR   Proteomes; UP000596680; Chromosome 2.
DR   GO; GO:0005921; C:gap junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR   InterPro; IPR000990; Innexin.
DR   PANTHER; PTHR11893; INNEXIN; 1.
DR   PANTHER; PTHR11893:SF40; INNEXIN SHAKING-B; 1.
DR   Pfam; PF00876; Innexin; 1.
DR   PRINTS; PR01262; INNEXIN.
DR   PROSITE; PS51013; PANNEXIN; 1.
PE   3: Inferred from homology;
KW   Cell junction {ECO:0000256|RuleBase:RU010713};
KW   Gap junction {ECO:0000256|ARBA:ARBA00022868, ECO:0000256|PROSITE-
KW   ProRule:PRU00351}; Ion channel {ECO:0000256|RuleBase:RU010713};
KW   Ion transport {ECO:0000256|RuleBase:RU010713};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW   ProRule:PRU00351}; Reference proteome {ECO:0000313|Proteomes:UP000007151};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW   ProRule:PRU00351};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW   ProRule:PRU00351}; Transport {ECO:0000256|RuleBase:RU010713}.
FT   TRANSMEM        23..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00351,
FT                   ECO:0000256|RuleBase:RU010713"
FT   TRANSMEM        113..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00351,
FT                   ECO:0000256|RuleBase:RU010713"
FT   TRANSMEM        183..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00351,
FT                   ECO:0000256|RuleBase:RU010713"
FT   TRANSMEM        273..300
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00351,
FT                   ECO:0000256|RuleBase:RU010713"
SQ   SEQUENCE   373 AA;  44718 MW;  77A2B921E0CD1011 CRC64;
     MLDVFRGLKN LIKVNYVHID SPVFRLHYSI TVVLLVSFSL IVTTRQYVGN PIDCIHTKDI
     PEDVLNTYCW IHSTYTLKSF FHKKVGVEVP YPGIGNSREK GKEDMSDRKI YKYYQWVCFC
     LFFQAMLFYA PRWLWKSWEG GKIRALMMDL DVGVCTEIEK KTKKKLILDY LWENLRYHNW
     WAYRYYLCEG LALINVIGQM FLMNRFFDGE FMTFGLDVIA YMESDQEDRI DPMIYIFPRM
     VKCTLFNKFG SSGEVERHDA LCILPLNVVN EKIYVFLWFW FVILGFLTFI TLVYRVVIIF
     SPRMRVYMMR MRFRLVRRDN VDTIVRRSKM GDWYLLYILG ENLDSVIFRD IMHEFANKLN
     HNYQHHIHGV PDA
//

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