ID A0A212EX59_DANPL Unreviewed; 1108 AA.
AC A0A212EX59;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Venus kinase receptor {ECO:0000313|EMBL:OWR46086.1};
GN Name=LOC116779509 {ECO:0000313|RefSeq:XP_032529721.1};
GN ORFNames=KGM_211051 {ECO:0000313|EMBL:OWR46086.1};
OS Danaus plexippus plexippus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Nymphalidae; Danainae; Danaini; Danaina; Danaus; Danaus.
OX NCBI_TaxID=278856 {ECO:0000313|EMBL:OWR46086.1, ECO:0000313|Proteomes:UP000007151};
RN [1] {ECO:0000313|EMBL:OWR46086.1, ECO:0000313|Proteomes:UP000007151}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F-2 {ECO:0000313|EMBL:OWR46086.1};
RX PubMed=22118469; DOI=10.1016/j.cell.2011.09.052;
RA Zhan S., Merlin C., Boore J.L., Reppert S.M.;
RT "The monarch butterfly genome yields insights into long-distance
RT migration.";
RL Cell 147:1171-1185(2011).
RN [2] {ECO:0000313|EMBL:OWR46086.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=F-2 {ECO:0000313|EMBL:OWR46086.1};
RA Zhan S., Reppert S.M.;
RT "MonarchBase: the monarch butterfly genome database.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:XP_032529721.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171};
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DR EMBL; AGBW02011826; OWR46086.1; -; Genomic_DNA.
DR RefSeq; XP_032529721.1; XM_032673830.1.
DR STRING; 278856.A0A212EX59; -.
DR EnsemblMetazoa; XM_032673830.1; XP_032529721.1; LOC116779509.
DR KEGG; dpl:KGM_211051; -.
DR eggNOG; KOG4258; Eukaryota.
DR OrthoDB; 3256854at2759; -.
DR Proteomes; UP000007151; Unassembled WGS sequence.
DR Proteomes; UP000596680; Chromosome 5.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro.
DR GO; GO:0007154; P:cell communication; IEA:UniProt.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00192; PTKc; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR PANTHER; PTHR24416:SF617; RECEPTOR PROTEIN-TYROSINE KINASE; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Kinase {ECO:0000313|EMBL:OWR46086.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Receptor {ECO:0000313|EMBL:OWR46086.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007151};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000313|EMBL:OWR46086.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1108
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041081487"
FT TRANSMEM 752..771
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 811..1089
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 843
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1108 AA; 125973 MW; B60A13280913FF00 CRC64;
MCSLVLFLLV LVLSWDRCYQ SPCSLLLHRL RERPTEELAV LVNGHLVEVV VWGGGGAPRA
AAALLLVALR VRGYRSHLHE AAPDVCGLLD ISDLKEAAVV APAATVPSED CRRAGLELLT
NFLQPAAVSY TLHLWAHVPS DRCRSQAGQW SFYKYYKDID ECGFLKAKFF NDITYGSCSN
CFAVLTRNES LVDNQIAMEL QTRIDAAELL LQVVSFKSDF IMRKTISELR RLQKPFLFVD
EDLWSDTFEM VYVQPPPCVR HVKNCIPFIK TIGNLRLGNG WFMYQFAPPI LELVNALSPK
SSQLREILNI ESAQNESHIE NAACSWALQH VEEFKTLILH DKLEQKKVFA IKIILCNHDP
LNKYFETISD LINRGEFQNN ITHIDYNIYK NTINCFDEEH FRQVITKNAQ KKNVAGVIAW
SWYKGTTGAA KVAEQSQLPL LLAGAVADEI PLGSAVRAAS GRLSDLTRAF HYILENCGWS
RIALLSDDSV YSRSFTEAMI KQKNLLYREV IVDFKNIYIN LDELKKADAR IFLLNVNWSL
SKDILNAALK RGMTPNNGFS WIAREWLPIQ NNNTDWADMY HFTVSLGWRG EQLEGGSKHL
QQKIRNRLHV KESLEEFPGI NYLSMFADAL LQLGYSFARF YQNYPSYRYN LRGYGTALKL
SEVFENMTIN GIAQNLSNRN SSIEHPLVFI NKWWGVRTKS IGILQITDNY IMALKPTASN
FKDLINRQKL RDRPICWTIS TGDPFTPRCQ DVTIIIVTVF LLISGTALYI ARRARLKRLL
KRELNILAKL LENRKRAVSS LDTYLVDRNA IKLLHEIGSG TFGRVHFAEL HRSGRSTVIV
AAKQPRQTIG PTEECEFLHE AYILAPLCHD NIIRLVGICI MNGPPMVLME HAYYLDLKRY
LTERRHLVSN RFNDNTSDAL DEVSDESLTR LAREAAGALA YLSTRRLVHR DVRAANCLID
KKRSLKLGDF GMARELDDKV PVYASIRRAL FPVLWMAPES LKSGVFSFAT DVWALGILIL
EVVTLGARPY GDWQLSRVLN YVVAGGIPPL PPDVSKHTSS LLHSCWERRA ESRPNASWVH
NHLTQYPRLL SPALLKPYPP DPLIAYME
//
