ID A0A212EY39_DANPL Unreviewed; 562 AA.
AC A0A212EY39;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE SubName: Full=Putative carotinoid oxygenase {ECO:0000313|EMBL:OWR46413.1};
GN ORFNames=KGM_212590 {ECO:0000313|EMBL:OWR46413.1};
OS Danaus plexippus plexippus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Nymphalidae; Danainae; Danaini; Danaina; Danaus; Danaus.
OX NCBI_TaxID=278856 {ECO:0000313|EMBL:OWR46413.1, ECO:0000313|Proteomes:UP000007151};
RN [1] {ECO:0000313|EMBL:OWR46413.1, ECO:0000313|Proteomes:UP000007151}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F-2 {ECO:0000313|EMBL:OWR46413.1};
RX PubMed=22118469; DOI=10.1016/j.cell.2011.09.052;
RA Zhan S., Merlin C., Boore J.L., Reppert S.M.;
RT "The monarch butterfly genome yields insights into long-distance
RT migration.";
RL Cell 147:1171-1185(2011).
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|PIRSR:PIRSR604294-1};
CC Note=Binds 1 Fe(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR604294-1};
CC -!- SIMILARITY: Belongs to the carotenoid oxygenase family.
CC {ECO:0000256|ARBA:ARBA00006787}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWR46413.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AGBW02011623; OWR46413.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A212EY39; -.
DR SMR; A0A212EY39; -.
DR STRING; 278856.A0A212EY39; -.
DR KEGG; dpl:KGM_212590; -.
DR eggNOG; KOG1285; Eukaryota.
DR InParanoid; A0A212EY39; -.
DR Proteomes; UP000007151; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; IEA:InterPro.
DR InterPro; IPR004294; Carotenoid_Oase.
DR PANTHER; PTHR10543; BETA-CAROTENE DIOXYGENASE; 1.
DR PANTHER; PTHR10543:SF24; CAROTENOID ISOMEROOXYGENASE; 1.
DR Pfam; PF03055; RPE65; 2.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR604294-1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR604294-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007151}.
FT BINDING 184
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
FT BINDING 242
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
FT BINDING 312
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
FT BINDING 500
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
SQ SEQUENCE 562 AA; 63677 MW; 284719C625E7C33B CRC64;
MEQCKEKLYP NCDNQVWLRS CEVEVNEPIT GEITGEFPRW VRGSLLRNGP GSLKVGSMRF
KHLFDSSALL HRFNIQDGQV TYQCRFLRCN TYNRNMAAGR IVVTDFGTQS VPDPCHSIFD
RFATLFSPGE ALSDNAMISV YPFGDEMYAF TEGPVIHRIN PVTLDTMERK NLMDSVALVN
HTSHPHVMSN GDVYNVGMSL VKGRLRHVVV KFPFMEKGDM FQNATIVGSM KPRWTLHPAY
MHTFGITANY FVIIEQPLSV SICRLVHNQL RNRPLASSLK WYPEHKTNIV LINRETGKEV
KRYETETLFF LHIINCYEIA NKLIVDLCSY KDAKILDAMY IQAIETMQTN ANYADWFRGR
PKRIEIDLNA PILTHFKPRL LADLGCETPR IHYDVYNGRP YRYFYAISSD VDAENPGLII
KVDTVTGQTQ TWFNNNCYPS EPVFVPRCDG KSEDDGVLLT ALVKADDSHS VSLVCLCAVT
LKELARCTFT TPSPTPKCLH GWFLPDSEDD GVLLTALVKA DDSHSVSLVC LCAVTLKELA
RCTFTTPSPT PKCLHGWFLP DV
//
