ID   A0A212EYH5_DANPL        Unreviewed;       721 AA.
AC   A0A212EYH5;
DT   27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT   27-SEP-2017, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=AMP deaminase {ECO:0000256|PIRNR:PIRNR001251};
DE            EC=3.5.4.6 {ECO:0000256|PIRNR:PIRNR001251};
GN   ORFNames=KGM_212863 {ECO:0000313|EMBL:OWR46546.1};
OS   Danaus plexippus plexippus.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC   Nymphalidae; Danainae; Danaini; Danaina; Danaus; Danaus.
OX   NCBI_TaxID=278856 {ECO:0000313|EMBL:OWR46546.1, ECO:0000313|Proteomes:UP000007151};
RN   [1] {ECO:0000313|EMBL:OWR46546.1, ECO:0000313|Proteomes:UP000007151}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F-2 {ECO:0000313|EMBL:OWR46546.1};
RX   PubMed=22118469; DOI=10.1016/j.cell.2011.09.052;
RA   Zhan S., Merlin C., Boore J.L., Reppert S.M.;
RT   "The monarch butterfly genome yields insights into long-distance
RT   migration.";
RL   Cell 147:1171-1185(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=AMP + H(+) + H2O = IMP + NH4(+); Xref=Rhea:RHEA:14777,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:58053, ChEBI:CHEBI:456215; EC=3.5.4.6;
CC         Evidence={ECO:0000256|PIRNR:PIRNR001251};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|PIRNR:PIRNR001251};
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676,
CC       ECO:0000256|PIRNR:PIRNR001251}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OWR46546.1}.
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DR   EMBL; AGBW02011505; OWR46546.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A212EYH5; -.
DR   STRING; 278856.A0A212EYH5; -.
DR   KEGG; dpl:KGM_212863; -.
DR   eggNOG; KOG1096; Eukaryota.
DR   InParanoid; A0A212EYH5; -.
DR   Proteomes; UP000007151; Unassembled WGS sequence.
DR   GO; GO:0003876; F:AMP deaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0032264; P:IMP salvage; IEA:InterPro.
DR   Gene3D; 4.10.800.20; -; 1.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   InterPro; IPR006329; AMPD.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   NCBIfam; TIGR01429; AMP_deaminase; 1.
DR   PANTHER; PTHR11359; AMP DEAMINASE; 1.
DR   PANTHER; PTHR11359:SF0; AMP DEAMINASE; 1.
DR   Pfam; PF19326; AMP_deaminase; 1.
DR   PIRSF; PIRSF001251; AMP_deaminase_met; 2.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR001251};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR001251};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007151}.
FT   REGION          1..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          150..179
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          492..512
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8..24
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   721 AA;  84466 MW;  F642777F34D1C64F CRC64;
     MFGTSKDVKN WNRERSETRR NQWGSTRMKI RGPGDGPRRS VPFQRISITG IHITGVPLDD
     LKRSASFLIN ALSLRKNYME ISNQSFPDDL AYYLTHNEGP PYFNDNKEKP QNNEAYLRFH
     PDLDEKYCDL TTCSSEELLN FQQIDRHNLR SETDRRIQDS QEDLQDEGPG DEDPWNCPTP
     PDRHLVYRWK HGVVQVYKNK EDAYENKKMN YRYLSFKQYV EDMSLLTDMI SDGPLKSFCY
     RRLSYLSSKF KMHVLLNELH ELALQKAVPH RDFYNVRKVD THIHAASCMN QKHLLRFIKR
     TLRAQPGQVV ALRDGLPITL KAVFEEMQLD AYDLNVDILD VHADRNTFHR FDRFNAKYNP
     VGESRLREVF LKTDNYMNGA YFADILKEVI SDLEDSKYTY AEPRISVYCK RASEWGELAA
     WALRRRVYSS HVRWLVQVPR LYDVYRINNL LKNFQEFLNN LFDPLFKVSI DPHSNPELHK
     FLTHVIGFDS VDDESKPENP NLTENMKTPE EWDDEENPPY AYYLYYMYAN IVMLNQLRKE
     QGLNTFVLRP HCGEAGPPAH LCAAFLLAEN ISHGLILRKV PALQYIYYLS QIFIAMSPLS
     NNSLFLRYHR NPLPDYFSRG LRVTLSTDDP LQFHYTKEPL MEEYGIAAQA WKFSSCDMCE
     LARNSVLMSG FPREMKQRWV GLTYERAGAA GNDIARTNVP DLRLTYRLET LRAELNNLFG
     V
//