ID A0A212EYH9_DANPL Unreviewed; 2020 AA.
AC A0A212EYH9;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Cacophony {ECO:0000313|EMBL:OWR46552.1};
GN ORFNames=KGM_213139 {ECO:0000313|EMBL:OWR46552.1};
OS Danaus plexippus plexippus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Nymphalidae; Danainae; Danaini; Danaina; Danaus; Danaus.
OX NCBI_TaxID=278856 {ECO:0000313|EMBL:OWR46552.1, ECO:0000313|Proteomes:UP000007151};
RN [1] {ECO:0000313|EMBL:OWR46552.1, ECO:0000313|Proteomes:UP000007151}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F-2 {ECO:0000313|EMBL:OWR46552.1};
RX PubMed=22118469; DOI=10.1016/j.cell.2011.09.052;
RA Zhan S., Merlin C., Boore J.L., Reppert S.M.;
RT "The monarch butterfly genome yields insights into long-distance
RT migration.";
RL Cell 147:1171-1185(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU003808}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWR46552.1}.
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DR EMBL; AGBW02011497; OWR46552.1; -; Genomic_DNA.
DR STRING; 278856.A0A212EYH9; -.
DR KEGG; dpl:KGM_213139; -.
DR eggNOG; KOG2301; Eukaryota.
DR InParanoid; A0A212EYH9; -.
DR Proteomes; UP000007151; Unassembled WGS sequence.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 6.10.250.2500; -; 2.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 5.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR031649; GPHH_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014873; VDCC_a1su_IQ.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF7; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR Pfam; PF08763; Ca_chan_IQ; 1.
DR Pfam; PF16905; GPHH; 1.
DR Pfam; PF00520; Ion_trans; 6.
DR PRINTS; PR00167; CACHANNEL.
DR SMART; SM01062; Ca_chan_IQ; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 6.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR602077-1};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000007151};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 134..155
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 167..186
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 262..284
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 350..371
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 383..405
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 575..593
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 605..623
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 700..722
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 776..800
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 857..876
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 896..917
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 929..949
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 995..1017
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1109..1134
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1190..1208
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1220..1242
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1254..1276
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1362..1385
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1405..1429
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1450..1475
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1491..1526
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 519..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1706..1725
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1741..1772
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1834..1912
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1986..2020
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1835..1853
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1855..1879
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2006..2020
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 364
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 754
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 1080
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
SQ SEQUENCE 2020 AA; 230717 MW; 939210891762AA5E CRC64;
MRFPFSVDHS TSFLNLGKTH CEVVRLQNCI KCDLRVAIDR LAAAQEAAGA QARAAPADTM
GGAHQPATPG PSSLFIFSDE NPIRRYTKFI IEWPPFEYAV LLTIIANCVV LALEEHLPNG
DKTILAQNLE KTEAYFLGIF CVEASLKILA LGFVLHRGSY LRNVWNIMDF FVVLTGSMTI
FAEYNVDVDL RMLRSFRVLR PLKLVSRIPS NSHIITQLPI APTEVDFRTL RAIRVLRPLK
LVSGVPSLQV VLKSIIKAMA PLLQIGLLVL FAIVIFAIIG LEFYSGALHK TCYNLEDITE
IVNDGDNPTP CNADNETLAP YGAHVCTYDK STCLEKWEGP NRGITSFDNI GFAMLTVFQC
ITMEGWTAIL YWTNDALGST FNWIYFVPLI VLGSFFMLNL VLGVLSGEFS NERGRVERRA
QFQKERARQA FNSDFTGYIN WITEAGLFEF AKEREKVENR QEFLKIRRQQ ILERELNGYV
EWICKAEEVI LAEERTTEEE RMHIIEARRR AAAKKKLKNL GKSKSTDTEE EEQDEECGDD
GFLKSKTRSA GKCADFWRAE KRFRFWIRHT VKTQWFYWFV IVLVLFNTIC VAVEHYRQPK
WLTSFLYYAE FVFLGLFMME MWVKMYALGP RIYFESSFNR FDCVVISGSI FEVVWSEVKG
GSFGLSVLRA LRLLRIFKVT KYWSSLRNLV ISLLNSMRSI ISLLFLLFLF ILIFALLGMQ
LFGGQFNFEE GTPPTNFNTF PIALLTVFQI LTGEDWNEVM YYGIQSQGGI QRGMIYSLYF
VILVLFGNYT LLNVFLAIAV DNLANAQELT AAEEEQGEEN KEAEIPDGPK PMLPYSSMFV
LSPTNPIRRG AHWIVNLRYF DFFIMVVICM SSVALAAEDP VVEESNRNKV LNYFDYAFTG
VFTVEMLLKI VDLGILFHPG AYLRDLWNIM DAAVVICALV SFGFEIGGVK KGAGQNLSTI
KSLRVLRVLR PLKTIKRVPK LKAVFDCVVN SLKNVINILI VYILFQFIFA VIAVQLFNGK
FFHCSDISKN TFEDCQGSFF VYESNSLLPQ VRKRQWTTQS FHYDNVASAM LTLFAVQTGE
GWPQVLQNSM AATYEDRGPI QNFRIEMSIF YIVYFVVFPF FFVNIFVALI IITFQEQGEA
ELQDGEIDKN QKSCIDFTIE ARPLERYMPS KRGSLKYKVW RIVVSTPFEY FIMALIVLNT
LLLMMKYYNQ NDLYADILKY SNMGFTGMFS VETVLKIIAY GVKFHEAPPL LMDVLTVMNI
VFTFFFLLET VLKLIAFGCT NFFKDPWNTF DFITVIGSII DALIMEFGSD LAENCADISC
QQENTFNVGF LRLFRAARLI KLLRQGYTIR ILLWTFVQSF KALPYVCLLI AMLFFIYAII
GMQVFGNIEL AADSDMNRHN NFRSFIQALM LLFRCATGES WPNIMLACLK PAKCDREADK
PPNEACGSTL AYAYFVSFIF FCSFLMLNLF VAVIMDNFDY LTRDSSILGA HHLDEFVRIW
AEYDPNATGK IHYTEMYDML KNMDPPLGFG NKCPNRLAFK KLIRMNMPLD EEGKVNFTTT
LFALIRENLS IKMRSAEEMD QADEELRETI THIWPLQAKK MLDLLVPRKD VLNAGKLTVG
KIYAGLLILE SWRTTGFKKQ GVPAFSENSP TANQPKATLF DCLMDAAAAA HGHGSRTGSL
THEIPVSGTD GHPEDPHMLA NLAKRSTRKS LKNNKKVLEL QDVGSHHASV ESLDEARLQA
PHVYQNGHGR SSSLRRSPSP RRRGHYGGYH HEIGFSDTVN NVVEIVKHEH HRHGRTHRAA
HHYHPHGKYT SELIKRGGRY MKVFLTAGKE WRAPYPTTSL SQPSRSPSPP QNTYGGDRER
ERDREREWRE WREGGRRGRG RQLPPTPTKP STLHVKQQPP FARISHSPSH LSLRHTAREP
LEPLHDEYEY GREVERLIHR DYRSRESLNE TGREFGRRGW GYESERGGRS YEAPLSYEAA
LALGRGGGAR ALPSPGPAPR LPNGYKPRVR HSDSDEDDWC
//
