ID A0A212EZ01_DANPL Unreviewed; 1583 AA.
AC A0A212EZ01;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Mitotic checkpoint serine/threonine-protein kinase BUB1 {ECO:0000313|EMBL:OWR46712.1};
GN ORFNames=KGM_202022 {ECO:0000313|EMBL:OWR46712.1};
OS Danaus plexippus plexippus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Nymphalidae; Danainae; Danaini; Danaina; Danaus; Danaus.
OX NCBI_TaxID=278856 {ECO:0000313|EMBL:OWR46712.1, ECO:0000313|Proteomes:UP000007151};
RN [1] {ECO:0000313|EMBL:OWR46712.1, ECO:0000313|Proteomes:UP000007151}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F-2 {ECO:0000313|EMBL:OWR46712.1};
RX PubMed=22118469; DOI=10.1016/j.cell.2011.09.052;
RA Zhan S., Merlin C., Boore J.L., Reppert S.M.;
RT "The monarch butterfly genome yields insights into long-distance
RT migration.";
RL Cell 147:1171-1185(2011).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWR46712.1}.
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DR EMBL; AGBW02011400; OWR46712.1; -; Genomic_DNA.
DR STRING; 278856.A0A212EZ01; -.
DR KEGG; dpl:KGM_202022; -.
DR eggNOG; KOG1166; Eukaryota.
DR InParanoid; A0A212EZ01; -.
DR Proteomes; UP000007151; Unassembled WGS sequence.
DR GO; GO:0000776; C:kinetochore; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0007094; P:mitotic spindle assembly checkpoint signaling; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd13981; STKc_Bub1_BubR1; 1.
DR Gene3D; 1.25.40.430; -; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR015661; Bub1/Mad3.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR013212; Mad3/Bub1_I.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR14030:SF4; BUB1 KINASE, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR14030; MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1; 1.
DR Pfam; PF08311; Mad3_BUB1_I; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00777; Mad3_BUB1_I; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51489; BUB1_N; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Kinase {ECO:0000313|EMBL:OWR46712.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000007151};
KW Transferase {ECO:0000313|EMBL:OWR46712.1}.
FT DOMAIN 45..201
FT /note="BUB1 N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51489"
FT DOMAIN 1300..1583
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 653..675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 716..739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 754..791
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 804..840
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 941..964
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1041..1060
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1123..1150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1177..1201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 759..773
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1177..1192
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 1329
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1583 AA; 180012 MW; 01E2FFF2DCAA9A69 CRC64;
MDIDVSKENI QPLRGGRNLM QLGTALQAQS DSDVQRQLLL QKDEHEEAIR QYQGPDPLEP
WFNYIQWVEQ SFPKHGHEGN IDKLIKDCLQ LFEKDERYFQ DRRLVKLWIK YVDCLSNPLE
IYQRLYNTGI GVECSEFYRA WACYCEESGD YKKANQVYML GLQAKAQPLD ELEQAHMNFQ
LFFAQRMLHD DSPTKRKAAS ALAETRMALT SLKSFKRRNI ANVPVQRVGD SVKSSLPGVV
RQQAVDNRLP NSNVMVNVYE DAPSTSRGVV TAEDPGPASL VQACNVENEK EVGIWTNPKT
KMVHTNVVPH QPLPFTPYED MDDDLKLSSK HMPYCLDDLT FNVPLCVPDP ADPTKIPCYN
KAQVYFNDKE YSLEEIRARK YNVQKAVKTE NVQVQETYKN INETLAQCSA LETLANCALD
SEQDHMGQLM PLTMPTLQNV TKVTNMHSPG EPKVLCNLDS KEVSELAAKK NDENEIPSSS
LSDKENQVAN HFNNENVGNF GKNNLMEEFN RSLMGNLLGD SVTVNTKEAR WELRNIFNDN
AEPSIVQPVV QQFDVPKFDI HEDRSMTMAI NAKKNFDIQD ARNMPEDKEN ANKFNAIQPN
VTSQAPNVFN FNIKNASTPN MSQFKKPSNI DQSSKFAVPK FSIDESVIEQ PDQISTKRDD
CSRQTNDQHA TVDNQGGGLS VIMEATREYN SKSGSSSSGQ SIRTNFTGYT TNFDSVYNNH
NDPNHPSTTS KRNSLSAQAR LPNGQFARAY PQKREAENKM AVTPSTSVPY HSHDHQYQKP
MPPNFSGYSP QRSIHYQQNY NYQQNFPNNH MMNQQQQGYG SPNPSSYQSP QHPSMQNSHE
MNQVPTGFQS PTYSNQMAYH QSPVNNPGNV MMSPQQGFTG RQDFHYSNHT DRHVYVNQQH
QVFQSPPHQT QFQNSVYYQR SSQPQTQNSY NQQNYHHIQS QYNNPNMYSS SGQNSNNPNF
NTVQSPYRQV PKQIENQASY GMSNNQQFQI YQSPQASQNS NLRNTSMHDA NMVQGYQETQ
GRQEMVDSLG KHERDVENTT LINNPQSKNS SSHKSPNNSV LRNVRYDQPN VKIGQKSPEV
GFSNQFLNFI SNRNEPKDNA NTPKFTNSPS ISQKMHKNLY VSSPEQAQIP PSSGLSDTDS
KDGMTAQTAT PIQSAKILTI DKQKDISKRQ LDFEHRDRVE IQSEDSRDSV SKDSRISSVY
SRQSDFQSDG YGMDIDSENS MECGAFKSSH SISMIETSDI PRPADIDFPK VIDPFNKKML
TSLLEYVKFP NKTHAEGYNE VRSIPKLQTA TVISVGNSKY SIEKQLGKGN YGAVFLCLDF
HSNKSVAVKY QKPSRPWEFY ICQEIKARIK DPFMLPGYME ISTAFLGENA SLFVSEYSRY
GSLLDVANKV RIATSKCINE LIVILLTSEM LSIVHYLHKA QIIHADIKPD NFLLMKIPTQ
EWRTPSLQLI DLGCAIDMSL FPEGTTFREL IATEGFTCTE MREGKPWTYQ TDLYCLAGTI
HVILMGSYMK VANRLGQWNI DKKLPRYMKN SLWDKIFTTL LNVPDCNNIP DLMELKNDVD
NVLNQIDCLG SQLRNFANVL KSR
//
