ID A0A212F5R9_DANPL Unreviewed; 307 AA.
AC A0A212F5R9;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Suppressor of cytokine signaling 2-like {ECO:0000313|RefSeq:XP_032520547.1};
DE SubName: Full=Suppressor of cytokine signaling 6 {ECO:0000313|EMBL:OWR49085.1};
GN Name=LOC116772456 {ECO:0000313|RefSeq:XP_032520547.1};
GN ORFNames=KGM_207274 {ECO:0000313|EMBL:OWR49085.1};
OS Danaus plexippus plexippus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Nymphalidae; Danainae; Danaini; Danaina; Danaus; Danaus.
OX NCBI_TaxID=278856 {ECO:0000313|EMBL:OWR49085.1, ECO:0000313|Proteomes:UP000007151};
RN [1] {ECO:0000313|EMBL:OWR49085.1, ECO:0000313|Proteomes:UP000007151}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F-2 {ECO:0000313|EMBL:OWR49085.1};
RX PubMed=22118469; DOI=10.1016/j.cell.2011.09.052;
RA Zhan S., Merlin C., Boore J.L., Reppert S.M.;
RT "The monarch butterfly genome yields insights into long-distance
RT migration.";
RL Cell 147:1171-1185(2011).
RN [2] {ECO:0000313|EMBL:OWR49085.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=F-2 {ECO:0000313|EMBL:OWR49085.1};
RA Zhan S., Reppert S.M.;
RT "MonarchBase: the monarch butterfly genome database.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:XP_032520547.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AGBW02010142; OWR49085.1; -; Genomic_DNA.
DR RefSeq; XP_032520547.1; XM_032664656.1.
DR STRING; 278856.A0A212F5R9; -.
DR EnsemblMetazoa; XM_032664656.1; XP_032520547.1; LOC116772456.
DR KEGG; dpl:KGM_207274; -.
DR eggNOG; KOG4566; Eukaryota.
DR OrthoDB; 5401079at2759; -.
DR Proteomes; UP000007151; Unassembled WGS sequence.
DR Proteomes; UP000596680; Chromosome 18.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR CDD; cd09923; SH2_SOCS_family; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF28; SUPPRESSOR OF CYTOKINE SIGNALING 6; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000007151};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 165..258
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 253..297
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
SQ SEQUENCE 307 AA; 35550 MW; 37B3AF875CE77279 CRC64;
MNKNYERCTH CNRRKWLATG CLRKWLKPME CKHLQRSIDS KRDFSNTDIV NCVFLPDRKP
PSNTNKFIKF WKNKLFITGS VRSLQRYFGN KNRDGEFMCD FNKTADPCTS RQIITVTNEV
KKDILAEHIT MKCKHSDGHS VLRGHHQHVS VESCAIYCQL SKHGWYWGGI TSSEAEELLA
GQHDNVFLVR DSYDLRHILC VSFRCVGRTL HARLRHANGL FSLNNETFVP ANRISEHCAT
VDVKSNLFEM PVKLARPLNR FAKLDSLQKI CRFVIRQTVS DNLWNKLPLP PNLIYYVSCG
SDYIAPV
//
