ID A0A212F5U9_DANPL Unreviewed; 1468 AA.
AC A0A212F5U9;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Putative ras GTP exchange factor son of sevenless {ECO:0000313|EMBL:OWR49103.1};
GN ORFNames=KGM_203453 {ECO:0000313|EMBL:OWR49103.1};
OS Danaus plexippus plexippus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Nymphalidae; Danainae; Danaini; Danaina; Danaus; Danaus.
OX NCBI_TaxID=278856 {ECO:0000313|EMBL:OWR49103.1, ECO:0000313|Proteomes:UP000007151};
RN [1] {ECO:0000313|EMBL:OWR49103.1, ECO:0000313|Proteomes:UP000007151}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F-2 {ECO:0000313|EMBL:OWR49103.1};
RX PubMed=22118469; DOI=10.1016/j.cell.2011.09.052;
RA Zhan S., Merlin C., Boore J.L., Reppert S.M.;
RT "The monarch butterfly genome yields insights into long-distance
RT migration.";
RL Cell 147:1171-1185(2011).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWR49103.1}.
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DR EMBL; AGBW02010130; OWR49103.1; -; Genomic_DNA.
DR STRING; 278856.A0A212F5U9; -.
DR KEGG; dpl:KGM_203453; -.
DR eggNOG; KOG3417; Eukaryota.
DR InParanoid; A0A212F5U9; -.
DR Proteomes; UP000007151; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd01261; PH_SOS; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 6.10.250.3060; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 2.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF373; PROTEIN SON OF SEVENLESS; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000007151}.
FT DOMAIN 210..397
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 444..553
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 601..797
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 842..1079
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1149..1175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1194..1294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1322..1349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1366..1468
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1205..1220
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1254..1285
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1468 AA; 165559 MW; 7883CF92DAC42482 CRC64;
MLPTVEETRG YDFQDPENAE KWKGFFISSL RKVLESVHPT LTADEGALEF VESLCLRLLG
MLCAPPAPLS VADGEERVAR SFPTPLDRWA LIEAREAAGA RRRKLLLPLE RLHLLLQKEV
LLYKIDMSVT TFMTVILEFI STDILRLAGN FVKKISQKSG YQVITCSDIK TAMCADKVLI
DMFYQDSELA SIAALPAFNT SERGRRASLS YGDLVRDLLA DERNFLRDLN LMIRVFKEEL
EKIVDDNKVI SLIFGNIVDI YELTVTLLGN LEDAMEMSQD TLTPYIGSCF EELAEVEEFR
AFVRYANIVT RRESRDALAA LVDDPQLGER LETAGHGFRL AVKYCLPRLL LSPVAHVFVY
HSYVLAMLPL APASDDRESF KQVECNLHPI EKLLTRALGN GPQLDGAMRS ASRARRKMAI
DKCNELARLV DNWDARDVPQ CCNEFIREDT LTKLGPGKRV AERRAFLFDG LLLLCKPVTS
LVTVNSGVTA GPPQLKLKEK LHIRKLDIVD RPDGEEGRNL MELCPRVGPP VVLAASSPAE
KRCWMSDLVI LNTKPMLDRS LDSILLDLER RHPLRLPSPS LYRFAEPDGP HNILLEHGHG
PAPLIKGATL LKLVERLTYH VHADLNLVRT FLTTYRSFCS PSELLALLIE RFDIPEPHLV
YDAPRPVPRI KIPRKDISPN ASLMDLDLDI GNIILYRVDL VETWLRADCV EISATSDAEK
LSKNTAREDW KRYRKEFQQP VKFRVINVLR HWVDQHFYDF EREPELLAKL KSFLEAVDGK
PMRKWVQSVL KTVQRKSGLQ SDNESLCSVS SGVSYVFDRL PPAPLRHVAE PDRHDWHPLA
LHPLEVARQL TLLEFQLYRQ VKPSELVGAA WTKKDKEKSS PNLFRISKNT TNFTRWIEKW
IVESENVEER AGVLSWCLEL AVALSDLNNF NGVFAVVAAC ESASVYRLKY TFQMLPPRLL
RALDQFRELS SDHFRLYQER LRSINPPCVP FVGVYLTKIL HIEEGNPDFL SNTELINFSK
RRMVAEITGE IQQYQNQPYC LTLEPRTRAF LENLDPFPGM DDNEVTNYLY GKSKEIEPKG
AVKQTHKFPR RYPELSLKPV KVSRRRHDTS STTLSSTNSL VSLDGAFSVS QLSPTSSVWD
GASVASLPLH AHDQGSREER SVTSPRLERA SSSSLAQLGQ LSLLDKLFDK SKSAATLHRN
SGSTKDDPPS PRDNHSPKRR PALSPRGALV EADMYQNRRR TDTQERVPPL LPRGGADPEA
PPVLPRRPPS PHTASTEPPP EPPDRPLPSP KHHDLFRHGE LAACTLIRNS YKINTLICYK
RPITPDPQES RAVPGRPARA QPHDGGQVRH TPCIQCEIYN EHSLARAGPD PVTWRPSASP
RPRLPDTSPV SDPVTTHPSP PHTSPLILTE HVSPPAETVP PPLPPRRRRD SAAPHTPHPV
SSKTPAEAGR GGRRPADLGR QRTRKLPN
//