ID A0A212FA27_DANPL Unreviewed; 562 AA.
AC A0A212FA27;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Coatomer subunit delta {ECO:0000256|RuleBase:RU366052};
GN Name=LOC116775606 {ECO:0000313|RefSeq:XP_032524418.1};
GN ORFNames=KGM_205869 {ECO:0000313|EMBL:OWR50592.1};
OS Danaus plexippus plexippus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Nymphalidae; Danainae; Danaini; Danaina; Danaus; Danaus.
OX NCBI_TaxID=278856 {ECO:0000313|EMBL:OWR50592.1, ECO:0000313|Proteomes:UP000007151};
RN [1] {ECO:0000313|EMBL:OWR50592.1, ECO:0000313|Proteomes:UP000007151}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F-2 {ECO:0000313|EMBL:OWR50592.1};
RX PubMed=22118469; DOI=10.1016/j.cell.2011.09.052;
RA Zhan S., Merlin C., Boore J.L., Reppert S.M.;
RT "The monarch butterfly genome yields insights into long-distance
RT migration.";
RL Cell 147:1171-1185(2011).
RN [2] {ECO:0000313|EMBL:OWR50592.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=F-2 {ECO:0000313|EMBL:OWR50592.1};
RA Zhan S., Reppert S.M.;
RT "MonarchBase: the monarch butterfly genome database.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:XP_032524418.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: The coatomer is a cytosolic protein complex that binds to
CC dilysine motifs and reversibly associates with Golgi non-clathrin-
CC coated vesicles, which further mediate biosynthetic protein transport
CC from the ER, via the Golgi up to the trans Golgi network.
CC {ECO:0000256|RuleBase:RU366052}.
CC -!- SUBUNIT: Oligomeric complex that consists of at least the alpha, beta,
CC beta', gamma, delta, epsilon and zeta subunits.
CC {ECO:0000256|RuleBase:RU366052}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU366052}. Golgi
CC apparatus membrane {ECO:0000256|ARBA:ARBA00004255,
CC ECO:0000256|RuleBase:RU366052}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004255, ECO:0000256|RuleBase:RU366052};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004255,
CC ECO:0000256|RuleBase:RU366052}. Cytoplasmic vesicle, COPI-coated
CC vesicle membrane {ECO:0000256|RuleBase:RU366052}; Peripheral membrane
CC protein {ECO:0000256|RuleBase:RU366052}; Cytoplasmic side
CC {ECO:0000256|RuleBase:RU366052}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the adaptor complexes medium subunit family.
CC Delta-COP subfamily. {ECO:0000256|ARBA:ARBA00010516,
CC ECO:0000256|RuleBase:RU366052}.
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DR EMBL; AGBW02009528; OWR50592.1; -; Genomic_DNA.
DR RefSeq; XP_032524418.1; XM_032668527.1.
DR STRING; 278856.A0A212FA27; -.
DR EnsemblMetazoa; XM_032668527.1; XP_032524418.1; LOC116775606.
DR KEGG; dpl:KGM_205869; -.
DR eggNOG; KOG2635; Eukaryota.
DR OrthoDB; 205756at2759; -.
DR Proteomes; UP000007151; Unassembled WGS sequence.
DR Proteomes; UP000596680; Chromosome 25.
DR GO; GO:0030126; C:COPI vesicle coat; IEA:UniProtKB-UniRule.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; IEA:UniProtKB-UniRule.
DR CDD; cd09254; AP_delta-COPI_MHD; 1.
DR CDD; cd14830; Delta_COP_N; 1.
DR Gene3D; 3.30.450.60; -; 1.
DR Gene3D; 2.60.40.1170; Mu homology domain, subdomain B; 1.
DR InterPro; IPR036168; AP2_Mu_C_sf.
DR InterPro; IPR022775; AP_mu_sigma_su.
DR InterPro; IPR027059; Coatomer_dsu.
DR InterPro; IPR011012; Longin-like_dom_sf.
DR InterPro; IPR028565; MHD.
DR PANTHER; PTHR10121; COATOMER SUBUNIT DELTA; 1.
DR PANTHER; PTHR10121:SF0; COATOMER SUBUNIT DELTA; 1.
DR Pfam; PF00928; Adap_comp_sub; 1.
DR Pfam; PF01217; Clat_adaptor_s; 1.
DR SUPFAM; SSF49447; Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor; 1.
DR SUPFAM; SSF64356; SNARE-like; 1.
DR PROSITE; PS51072; MHD; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU366052};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW ER-Golgi transport {ECO:0000256|ARBA:ARBA00022892,
KW ECO:0000256|RuleBase:RU366052};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034,
KW ECO:0000256|RuleBase:RU366052}; Membrane {ECO:0000256|RuleBase:RU366052};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|RuleBase:RU366052};
KW Reference proteome {ECO:0000313|Proteomes:UP000007151};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU366052}.
FT DOMAIN 322..562
FT /note="MHD"
FT /evidence="ECO:0000259|PROSITE:PS51072"
FT REGION 234..295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 562 AA; 62851 MW; 21A5D5FFB7078580 CRC64;
MSKQQHNIEL YVHIRMVLST VVLTKFGKSW GSSCKIGDVR RGSRSPDRGA PRSERLRHAS
HLFISTHVLI AATVCTKSGK ALVSRQFVEM TKARIEGLLA AFPKLMTGGR QHTFIETESV
RYVYQPLDKL YMLLITTKAS NILEDLETLR LFSRVVPEYC TQLTEAEILN QAFNLLFAFD
EIVALGYRES VNLAQVRSFV EMDSHEEKIY QAVRQVSSYK FIYRNKNLPS NLFDKATASP
PRSSGFGSGF GSSSLPQTTP SEPTTEKIPT TPARETRTTT RSAMKLGSRG TDTESFVSRL
RSEGDVAAAP VKIEKTVVTT NNKDVHLRFE ERLNLVAGRD GDIQSFELSG LLTLRISNEQ
FGKIQVHVDN KDTRPLQLQT HPNVDKEHFR TSGVVRLKAA QRAFPVNSDV GVLKWRLANT
GDTPQPLSVN CWPSEGANGT CDVNIEYELE QEHLALADVN INIPLPAGNT TLVVHQWEGS
YTQKGKMLVW NIPLINKQQK SGTLEFTVTP AIRNDFFPLS VTWTSETPLA MLTATKVTTA
EEGNNVDFSQ EISFHPDKYE IV
//
