ID   A0A212FEB2_DANPL        Unreviewed;      1274 AA.
AC   A0A212FEB2;
DT   27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT   27-SEP-2017, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=Cytoplasmic FMR1-interacting protein {ECO:0000256|PIRNR:PIRNR008153};
GN   Name=LOC116778460 {ECO:0000313|RefSeq:XP_032528360.1};
GN   ORFNames=KGM_208107 {ECO:0000313|EMBL:OWR52053.1};
OS   Danaus plexippus plexippus.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC   Nymphalidae; Danainae; Danaini; Danaina; Danaus; Danaus.
OX   NCBI_TaxID=278856 {ECO:0000313|EMBL:OWR52053.1, ECO:0000313|Proteomes:UP000007151};
RN   [1] {ECO:0000313|EMBL:OWR52053.1, ECO:0000313|Proteomes:UP000007151}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F-2 {ECO:0000313|EMBL:OWR52053.1};
RX   PubMed=22118469; DOI=10.1016/j.cell.2011.09.052;
RA   Zhan S., Merlin C., Boore J.L., Reppert S.M.;
RT   "The monarch butterfly genome yields insights into long-distance
RT   migration.";
RL   Cell 147:1171-1185(2011).
RN   [2] {ECO:0000313|EMBL:OWR52053.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=F-2 {ECO:0000313|EMBL:OWR52053.1};
RA   Zhan S., Reppert S.M.;
RT   "MonarchBase: the monarch butterfly genome database.";
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|RefSeq:XP_032528360.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the CYFIP family.
CC       {ECO:0000256|ARBA:ARBA00025790, ECO:0000256|PIRNR:PIRNR008153}.
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DR   EMBL; AGBW02008966; OWR52053.1; -; Genomic_DNA.
DR   RefSeq; XP_032528360.1; XM_032672469.1.
DR   STRING; 278856.A0A212FEB2; -.
DR   EnsemblMetazoa; XM_032672469.1; XP_032528360.1; LOC116778460.
DR   KEGG; dpl:KGM_208107; -.
DR   eggNOG; KOG3534; Eukaryota.
DR   OrthoDB; 446059at2759; -.
DR   Proteomes; UP000007151; Unassembled WGS sequence.
DR   Proteomes; UP000596680; Chromosome 30.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0030833; P:regulation of actin filament polymerization; IEA:InterPro.
DR   InterPro; IPR009828; CYRIA/CYRIB_Rac1-bd.
DR   InterPro; IPR008081; Cytoplasmic_FMR1-int.
DR   PANTHER; PTHR12195:SF0; CYTOPLASMIC FMR1-INTERACTING PROTEIN; 1.
DR   PANTHER; PTHR12195; CYTOPLASMIC FMR1-INTERACTING PROTEIN-RELATED; 1.
DR   Pfam; PF07159; CYRIA-B_Rac1-bd; 1.
DR   Pfam; PF05994; FragX_IP; 1.
DR   PIRSF; PIRSF008153; FMR1_interacting; 1.
DR   PRINTS; PR01698; CYTOFMRPINTP.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|PIRNR:PIRNR008153};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007151}.
FT   DOMAIN          63..277
FT                   /note="CYRIA/CYRIB Rac1 binding"
FT                   /evidence="ECO:0000259|Pfam:PF07159"
SQ   SEQUENCE   1274 AA;  145685 MW;  9BE4FB07518B50E0 CRC64;
     MSVSEKVSLS DALSNVDVLD ELTLPDEQPC IEAAPCSILY QANFDTNFED RNGFVTGIAK
     YIEEATVHAN LNELLEQGNA HAVMLYTWRC CSRAIPQPRS NEQPDRVHIY ERTVQVLAPE
     VNKLLQFMYF QRKAIERFCG EVRRLCHAEK RRDFVSEAYL LTLGKFVNMF AVLDELKNMK
     SSVKNDYSTY RRAAQFLKVM SDSQSLQESQ NLSMFLATQN KIRDTVKDAL EKITGYEDLL
     CDVVNICVHM FETKMYLTPS EKHMLVKVMG FGLFLMDSEV CNINRLDQKK KIRLDRIDRI
     FKNLEVVPLF GDMQIAPFNY IKRSKHYDPS KWPLSSSPSP PSPQADLMVH LPQIRDEHQD
     YISELARYSN EVTTTFKEAG SDAENRAVCE LCLRGLQLLS SWCSVLTELC SWKLLHPTDH
     ATNPRCPPDA EEYERATRYN YTSEEKFAVI EVVAMIKGLQ VLMARMETVF ADAARRAIYA
     ELQDFVTLAL REPLRKAIKN KKDLIRSIIV SVRETCGDWA RGCEPQQDPA LRGKKDSENS
     FTIKVPRRNV GPSSTQLYMV RTQLEALISD KSGGRRTLRK DLDAGILQQI ETFHRQSFYW
     TYLLNLADSL SKCCDLSQLW YREFYLEMTM GRKVNKCTVR HQHNEECNDL ITMEKRIQFP
     IEMSMPWILT EHILRSKDPS MMEYVLYPLD LYNDSAQYAL TVFKKQFLYD EVEAEVNLCF
     DQFVYKLSEL VYSHYKQLAA SMLLDTRYRA DCAARGAGAA PSAGGAGRYA SLLRQRHVAL
     LGRHVDLCAL VAQRINADMH RALDAAVAKF EAGDITGVVE LEGLIAVNRL CHKLLSRYLT
     LDEFDAILRE SDHGVLAPYG RITLHVFWEL NYDFLPNYCY NAATDRFVKC RGIQFAAPVV
     REKPQQFGHA VLWGSKQLSL AYSAQYAQYN GFVGPQHLHS LVRLLGYQGV SVVVSELLGV
     ARMLLHGNLA QFTRALAAAM PRHCKLPRYD YGSNGVLGYY HAQLTDIVQY PDARTELFHS
     FRELGNIILF CMLIEQALSQ EEVTDLLHAA PFQNILPRPF TAEGEKPETK QKRLEAKYAP
     LQIVQNVEKY GTAKQSQLSR EGDLLTRERL CCGLSLFSVV LRRLKAVLSA PAWPAPPSSQ
     HTYIHTDDTA EFHRLWSALQ FLYCIPVGDT QFTVEELFGE GLHWAGCTII ALLGQQRRFE
     ALDFCYHILR VQRVDGKDEL VKGIPLKRMV DRIRRFQVLN SQIFSVLSRH LAADDERSGV
     EHVRCYPPPA AHHP
//