ID A0A212FFU8_DANPL Unreviewed; 921 AA.
AC A0A212FFU8;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Putative leucine-rich transmembrane protein {ECO:0000313|EMBL:OWR52600.1};
GN ORFNames=KGM_205818 {ECO:0000313|EMBL:OWR52600.1};
OS Danaus plexippus plexippus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Nymphalidae; Danainae; Danaini; Danaina; Danaus; Danaus.
OX NCBI_TaxID=278856 {ECO:0000313|EMBL:OWR52600.1, ECO:0000313|Proteomes:UP000007151};
RN [1] {ECO:0000313|EMBL:OWR52600.1, ECO:0000313|Proteomes:UP000007151}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F-2 {ECO:0000313|EMBL:OWR52600.1};
RX PubMed=22118469; DOI=10.1016/j.cell.2011.09.052;
RA Zhan S., Merlin C., Boore J.L., Reppert S.M.;
RT "The monarch butterfly genome yields insights into long-distance
RT migration.";
RL Cell 147:1171-1185(2011).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|ARBA:ARBA00010663}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWR52600.1}.
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DR EMBL; AGBW02008766; OWR52600.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A212FFU8; -.
DR STRING; 278856.A0A212FFU8; -.
DR KEGG; dpl:KGM_205818; -.
DR eggNOG; KOG0619; Eukaryota.
DR eggNOG; KOG2087; Eukaryota.
DR InParanoid; A0A212FFU8; -.
DR Proteomes; UP000007151; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0016500; F:protein-hormone receptor activity; IEA:InterPro.
DR CDD; cd15136; 7tmA_Glyco_hormone_R; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR002131; Gphrmn_rcpt_fam.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR24372; GLYCOPROTEIN HORMONE RECEPTOR; 1.
DR PANTHER; PTHR24372:SF82; RICKETS; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR Pfam; PF13855; LRR_8; 3.
DR PRINTS; PR00373; GLYCHORMONER.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SMART; SM00369; LRR_TYP; 8.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR PROSITE; PS51450; LRR; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000007151};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 408..429
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 441..464
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 484..505
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 526..547
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 567..592
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 613..636
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 648..668
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 419..665
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT REGION 699..721
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 763..899
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 778..799
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 817..854
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 921 AA; 99671 MW; 4E68BE7B0EBC37F8 CRC64;
MTKHVKLGVR LVHNASYRFY QCLVSVGALY DAGRLEDNLL TELPPAIYLL PSLEDLSLSN
NLVEVVGGGL RACSRLARLE LRGNPLSALE PHALTHLPRL TTLVLSEARG LSVFPSLNGS
SRLNTLRLDR ARLTRLPSDL CLHAPLLRAL DLRSNKLEHV PDLQQCSELR VLDISDNQVS
SLGAGALTGL RRLHDLLVAR NRLRRISADT FVHTPRLQLL DLEDNEIEHI DMEAFVPINK
LEDLNVGNNR FPVLPASGLQ RLLHLKAHNN PALRRFHPPE AFPRIQTLVL SYAYHCCEFM
PLMEGGSSSA GSAESAESGD EEPEQFSDLV LLPPAHVDLA AWANATDIWP HYLNATGESS
SRLAAVGWGD VSAAELKYGG NRRVRCLPLP GPFLPCVDLF DWWTLRCGVW AVFLLALLGN
GTVVFVLVFS RSRIDVPRFL VTNLAAADFF MGIYLGFLAV VDAGTLGEFR AHAIAWQMSG
GCRLAGFLGV LSSELSVYTL AVITLERNYA ITHAMHLNKR LSLRHAAAVM AAGWAFSLAA
AALPLLGVSD YRKFAVCLPF ETSSPAALGY VVSLLIINGF AFLVLLGCYL KMYCAIRGSQ
AWNSNDSRIA KRMALLVFTD FLCWSPIAFF ALTAAFGAQL VSLEEAKVFT VFVLPLNSCC
NPFLYAILTK QFKKDCALVC KAIEESRVTR GIGRCRHSSN FSNRQTPANT NSLNERSSRG
QHGATCACRR LLPTGGVGEG PTAPTEPGGE RLLRWLRACG RRATAPAPPA PRQPPTAPVR
TGSVSSSVEF SSSRSDSWRT YGRPPPPPRR AASWLVARKT SQDSNLSSSR NDSSGSNATA
STGTWRTSRS GGSATAGAGG AGGPVVPSAG VASGRPRLTR QPAVMADEPP LSPGALPAPR
LLHTIPSAAE TEATLEEPDV R
//
