ID A0A212FL19_DANPL Unreviewed; 1783 AA.
AC A0A212FL19;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Probable Ras GTPase-activating protein isoform X3 {ECO:0000313|RefSeq:XP_032511636.1};
DE SubName: Full=Synaptic ras GTPase activating protein {ECO:0000313|EMBL:OWR54434.1};
GN Name=LOC116766076 {ECO:0000313|RefSeq:XP_032511636.1};
GN ORFNames=KGM_213125 {ECO:0000313|EMBL:OWR54434.1};
OS Danaus plexippus plexippus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Nymphalidae; Danainae; Danaini; Danaina; Danaus; Danaus.
OX NCBI_TaxID=278856 {ECO:0000313|EMBL:OWR54434.1, ECO:0000313|Proteomes:UP000007151};
RN [1] {ECO:0000313|EMBL:OWR54434.1, ECO:0000313|Proteomes:UP000007151}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F-2 {ECO:0000313|EMBL:OWR54434.1};
RX PubMed=22118469; DOI=10.1016/j.cell.2011.09.052;
RA Zhan S., Merlin C., Boore J.L., Reppert S.M.;
RT "The monarch butterfly genome yields insights into long-distance
RT migration.";
RL Cell 147:1171-1185(2011).
RN [2] {ECO:0000313|EMBL:OWR54434.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=F-2 {ECO:0000313|EMBL:OWR54434.1};
RA Zhan S., Reppert S.M.;
RT "MonarchBase: the monarch butterfly genome database.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:XP_032511636.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AGBW02007907; OWR54434.1; -; Genomic_DNA.
DR RefSeq; XP_032511636.1; XM_032655745.1.
DR STRING; 278856.A0A212FL19; -.
DR EnsemblMetazoa; XM_032655745.1; XP_032511636.1; LOC116766076.
DR KEGG; dpl:KGM_213125; -.
DR eggNOG; KOG3508; Eukaryota.
DR Proteomes; UP000007151; Unassembled WGS sequence.
DR Proteomes; UP000596680; Chromosome 2.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR CDD; cd13262; PH_RasSynGAP-like; 1.
DR CDD; cd05136; RasGAP_DAB2IP; 1.
DR Gene3D; 1.10.506.20; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR021887; DAB2P_C.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF125; RAS GTPASE-ACTIVATING PROTEIN RASKOL; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF12004; DAB2P_C; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000007151}.
FT DOMAIN 448..482
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 473..592
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 655..848
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 71..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 159..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 335..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 883..937
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1136..1160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1350..1477
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1577..1615
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1755..1783
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1654..1681
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 96..110
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..181
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..219
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 883..926
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1367..1399
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1400..1424
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1443..1477
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1757..1783
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1783 AA; 201625 MW; F76065997EB674CC CRC64;
MSETLSPNSS PSCDENSRRR SVFYVPLFES FDNYLPLTPE EKEAILCGQN VEQTPKKPRR
KNTAEYGRLH IHSRAETSSI ESESDFSPVR RYPRPLSSRM SSNEALAREG QSDLTSPRLV
AESNVIRHRH PRLRTTTSCE PRYDRIYSPL TTSISSNKLN NSTSSISVRL PSKNPIRNSN
LSLIPDAPKM LSPPKEKSKT LPQNLNTPSP IRGSSSSTSI FKTPKITVTP ESPHKSPGKM
TGLNFIRRSR STKLSRSNSL LRSITARYIE EGLEDNVAVI TDLTDNYNKF VDDNGGEKEV
ICALIKKNEE QITNSPLSMR RTYLDADDDL AVHSDTSYET SCRRGSAPST PIPGTQAQHS
PSRLASFFFS KRSFRSNPLK RTKSAAKIES KQVLAAVPTH PATHALRTSR SHESLLSAQS
PAVSTMDLGP PNQVEIRALH SSVLGRPHCF ALSAENRAPR YFACASRKER DRWIYSLRQA
ARPDEMRTRR CERTVKLWLL EAKAIPPKKR YYCEILLDDN LHARSSSKLK TELCFWGEVY
EFCSLPPVRY INVNVYREPE RRPRKRDKHA LVGTVRIPVD DVSSRYPNER WYPISEDKPQ
SPARAPAPLP ALRIKCRYQC VDVLPIDCYV RFLDYLKKNY RRLCEYLEPV IGVKAKEDIG
CALVLCMAGA GLAPRYLADV VALDVRRTGD HSLTFRGNSL ATKSMEAYLK LVGDQYLQDT
LGEAVLSAAG PGAPECEVDP LRAGSGAALR RHQAALRDTV SLAWSAIASS ATRFPPPLRD
CFATFRERLA SMGREDISDN LISASIFLRF LCPAILSPSL FGIIHEYPNE RAARNLTLVA
KTLQTLANFT RFQGKEAFME FLNDFLEQEA PNMKAFLRAI STRPQEQQQH QTSQQQQQHQ
SSQQQQQQSN QSDSKRNSST SHSSVEGEVD PDPEWAPHVD LGKQLATLHS LLVDSLPKLC
AAKIQELDPL SDILDELSKR LLSNDNGPIP QIGDNIFRFN DPTCNAQTKQ NNETSTNGPL
TNNFAHSSPI MNKNGVQFNI SPSKSNAEDS KYKGSFATVS KSPSFNLRSA TLPRNGYGTN
QVNQNVNPDR YSSQYNNQEH CVNLKVVQIG FGSDQYPKGI SNSVNENERR FQDRYKPNNF
NQGHFHNTNY NSTERSPSSD SINHNYCSND MQNIMKETAT LDELSDLLKY ADDSDIVDEK
MMNKKNISQS KTNNNNIING NKNSYTNNGS NVSISGLSNV ASSGYQSIAT YSQSSSPIEN
ATHLHQAYEN GGQPMSRYSQ LNYQKQRDKQ YYENKNEKFY PKSPVQQKIE YDIQKYGIQN
FTTADNVQNN TNANTKVAPL VFTNPVYNME DNRQSQDVKK PNENRNSKRC PCGSSSSSID
EEGLSTDNVE TNSEEGSTNF NDDRNFDKQN RNATHRKLTR DNCNYEDVYQ RTTNHSSSPR
IRDDESSSNS PSLRKASKTR MPRTNPMLSY STNQNQLNLK HFGQRGESLY ESKPHHISTD
SGYPMSRSDS NVEEVNKEMY RLQISRSQKA LYNMENSKNS PEKFIAENSI PETNYPLDRT
YSGAKISSSR LNEDLERHQD YYGVRERRES PSRGFNRESH SSEASERVPV RVDREAPVRD
KLQRRLSLES ARELTDSSSE VDDTFYSTTG RKRANKHHRT IEQYEREIER LKCSVELLRG
RLGPTDSGQD QTDAKMKAII SRLICVEEEL RREQRKMAAA LSHKQRVIEA QEHRIAALDE
ANTRLLSALV HLQQRAPHPP SHNNNHSTSH SPHSQHSHQE LQI
//
