ID A0A212FLS5_DANPL Unreviewed; 609 AA.
AC A0A212FLS5;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Carnitine O-palmitoyltransferase 2 {ECO:0000313|EMBL:OWR54649.1};
GN ORFNames=KGM_214065 {ECO:0000313|EMBL:OWR54649.1};
OS Danaus plexippus plexippus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Nymphalidae; Danainae; Danaini; Danaina; Danaus; Danaus.
OX NCBI_TaxID=278856 {ECO:0000313|EMBL:OWR54649.1, ECO:0000313|Proteomes:UP000007151};
RN [1] {ECO:0000313|EMBL:OWR54649.1, ECO:0000313|Proteomes:UP000007151}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F-2 {ECO:0000313|EMBL:OWR54649.1};
RX PubMed=22118469; DOI=10.1016/j.cell.2011.09.052;
RA Zhan S., Merlin C., Boore J.L., Reppert S.M.;
RT "The monarch butterfly genome yields insights into long-distance
RT migration.";
RL Cell 147:1171-1185(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(R)-carnitine + 4,8-dimethylnonanoyl-CoA = CoA + O-4,8-
CC dimethylnonanoyl-(R)-carnitine; Xref=Rhea:RHEA:44860,
CC ChEBI:CHEBI:16347, ChEBI:CHEBI:57287, ChEBI:CHEBI:77061,
CC ChEBI:CHEBI:84654; Evidence={ECO:0000256|ARBA:ARBA00024283};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005232, ECO:0000256|RuleBase:RU003801}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWR54649.1}.
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DR EMBL; AGBW02007731; OWR54649.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A212FLS5; -.
DR STRING; 278856.A0A212FLS5; -.
DR KEGG; dpl:KGM_214065; -.
DR eggNOG; KOG3719; Eukaryota.
DR InParanoid; A0A212FLS5; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000007151; Unassembled WGS sequence.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.20.1280.180; -; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 1.10.275.20; Choline/Carnitine o-acyltransferase; 1.
DR Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR InterPro; IPR000542; Carn_acyl_trans.
DR InterPro; IPR042572; Carn_acyl_trans_N.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR039551; Cho/carn_acyl_trans.
DR InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR PANTHER; PTHR22589; CARNITINE O-ACYLTRANSFERASE; 1.
DR PANTHER; PTHR22589:SF16; CARNITINE O-PALMITOYLTRANSFERASE 2, MITOCHONDRIAL; 1.
DR Pfam; PF00755; Carn_acyltransf; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR PROSITE; PS00440; ACYLTRANSF_C_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW ECO:0000256|RuleBase:RU003801};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000007151};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003801};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 10..598
FT /note="Choline/carnitine acyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00755"
FT ACT_SITE 331
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
SQ SEQUENCE 609 AA; 69840 MW; 4EBFD8B348199E2E CRC64;
MHFQKSLPRL PIPDLSKSRD RYLNAIRPLL AKDQYETAVK RTDKFVNNEG KELQSKLVNK
DKMNKQTSYI SDYWFDLYLR DRSALPINYN PLIVFQNDLR PDYNDQLLRT SNLLVSAVRF
MMALREQILE PEVYHLQPKK SNTPLFRTVT GLLPESLSWY GAYLFKAFPL DMSQFVGLFN
ATRIPLVGKD KIFRDTSCNH VVVQRNGHFY IFDVVDSNGN ILSPTEILGN MSQIMEDKTP
KAEYPVGILT TQNRDVWAKQ RIYLEENGNQ ETLKKIDSAI FNIVLDDETI DDNKHKILTN
YLHGDGLNRW FDKSFSLITT KDGVSGINFE HSWGDGVAVL RFFEDIYKET TTKPFITPDS
RPSKNNITVK KIEFNLDDKS KNFIVNAKNE YSDWCNSLSI DYILYEQLTK EACKKLKVSP
DCIMQLGFQA AYHLLHGKYV GTYESCSTSA FKHGRTETMR PCTDKTKAFC DLLHSKKASD
QELRSLMQEC SLYHSNLTKE AAMGQGFDRH MFALMKIAEE NHMPRPEIFD SYEYKYLNKS
ILSTSTLSSP SVLAGGFGPV VKEGFGIGYS AFADKLGAAV ASYKQHNNSS EFVQALQKSF
EDIRKILSY
//