UniProt: A0A212FPV5

Database: UniProt
Entry: A0A212FPV5_DANPL

LinkDB:  A0A212FPV5_DANPL 
Original site:  A0A212FPV5_DANPL

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Ontology (4)   
   GO (4)   
Chemical reaction (2)   
   KEGG ENZYME (2)   
Gene (1)   
   KEGG GENES (1)   
Protein sequence (2)   
   RefSeq(pep) (2)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (10)   
   InterPro (7)   
   Pfam (2)   
   SMART (1)   
Literature (1)   
   PubMed (1)   
All databases (21)   

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ID   A0A212FPV5_DANPL        Unreviewed;       354 AA.
AC   A0A212FPV5;
DT   27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT   27-SEP-2017, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=Prostaglandin reductase 1 {ECO:0000256|ARBA:ARBA00020651};
DE            EC=1.3.1.48 {ECO:0000256|ARBA:ARBA00011981};
DE            EC=1.3.1.74 {ECO:0000256|ARBA:ARBA00012410};
DE   AltName: Full=15-oxoprostaglandin 13-reductase {ECO:0000256|ARBA:ARBA00033119};
DE   AltName: Full=Dithiolethione-inducible gene 1 protein {ECO:0000256|ARBA:ARBA00032255};
DE   AltName: Full=Leukotriene B4 12-hydroxydehydrogenase {ECO:0000256|ARBA:ARBA00031851};
DE   AltName: Full=NAD(P)H-dependent alkenal/one oxidoreductase {ECO:0000256|ARBA:ARBA00032297};
GN   Name=LOC116770165 {ECO:0000313|RefSeq:XP_032517418.1,
GN   ECO:0000313|RefSeq:XP_032517419.1};
GN   ORFNames=KGM_207815 {ECO:0000313|EMBL:OWR55798.1};
OS   Danaus plexippus plexippus.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC   Nymphalidae; Danainae; Danaini; Danaina; Danaus; Danaus.
OX   NCBI_TaxID=278856 {ECO:0000313|EMBL:OWR55798.1, ECO:0000313|Proteomes:UP000007151};
RN   [1] {ECO:0000313|EMBL:OWR55798.1, ECO:0000313|Proteomes:UP000007151}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F-2 {ECO:0000313|EMBL:OWR55798.1};
RX   PubMed=22118469; DOI=10.1016/j.cell.2011.09.052;
RA   Zhan S., Merlin C., Boore J.L., Reppert S.M.;
RT   "The monarch butterfly genome yields insights into long-distance
RT   migration.";
RL   Cell 147:1171-1185(2011).
RN   [2] {ECO:0000313|EMBL:OWR55798.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=F-2 {ECO:0000313|EMBL:OWR55798.1};
RA   Zhan S., Reppert S.M.;
RT   "MonarchBase: the monarch butterfly genome database.";
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|RefSeq:XP_032517418.1, ECO:0000313|RefSeq:XP_032517419.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate +
CC         NADP(+) = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate +
CC         H(+) + NADPH; Xref=Rhea:RHEA:51212, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133974,
CC         ChEBI:CHEBI:133975; Evidence={ECO:0000256|ARBA:ARBA00023498};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51213;
CC         Evidence={ECO:0000256|ARBA:ARBA00023498};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=13,14-dihydro-15-oxo-PGF2alpha + NADP(+) = 15-oxoprostaglandin
CC         F2alpha + H(+) + NADPH; Xref=Rhea:RHEA:50588, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133374,
CC         ChEBI:CHEBI:133409; Evidence={ECO:0000256|ARBA:ARBA00023548};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50590;
CC         Evidence={ECO:0000256|ARBA:ARBA00023548};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) = 15-
CC         oxoprostaglandin E1 + H(+) + NADPH; Xref=Rhea:RHEA:50584,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57401, ChEBI:CHEBI:57783,
CC         ChEBI:CHEBI:58349, ChEBI:CHEBI:133408;
CC         Evidence={ECO:0000256|ARBA:ARBA00023544};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50586;
CC         Evidence={ECO:0000256|ARBA:ARBA00023544};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) = 15-
CC         oxoprostaglandin F1alpha + H(+) + NADPH; Xref=Rhea:RHEA:50592,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC         ChEBI:CHEBI:79072, ChEBI:CHEBI:133411;
CC         Evidence={ECO:0000256|ARBA:ARBA00023543};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50594;
CC         Evidence={ECO:0000256|ARBA:ARBA00023543};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=20-hydroxy-leukotriene B4 + NADP(+) = 12-oxo-20-hydroxy-
CC         leukotriene B4 + H(+) + NADPH; Xref=Rhea:RHEA:51208,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57460, ChEBI:CHEBI:57783,
CC         ChEBI:CHEBI:58349, ChEBI:CHEBI:133346;
CC         Evidence={ECO:0000256|ARBA:ARBA00023517};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51209;
CC         Evidence={ECO:0000256|ARBA:ARBA00023517};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4-hydroxynonanal + NADP(+) = (E)-4-hydroxynon-2-enal + H(+) +
CC         NADPH; Xref=Rhea:RHEA:64736, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783,
CC         ChEBI:CHEBI:58349, ChEBI:CHEBI:58968, ChEBI:CHEBI:156112;
CC         Evidence={ECO:0000256|ARBA:ARBA00023553};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:64738;
CC         Evidence={ECO:0000256|ARBA:ARBA00023553};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=6-trans-leukotriene B4 + NADP(+) = 12-oxo-(5S)-hydroxy-
CC         (6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH;
CC         Xref=Rhea:RHEA:51204, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783,
CC         ChEBI:CHEBI:58349, ChEBI:CHEBI:90723, ChEBI:CHEBI:133974;
CC         Evidence={ECO:0000256|ARBA:ARBA00023496};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51205;
CC         Evidence={ECO:0000256|ARBA:ARBA00023496};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=NADP(+) + nonan-2-one = (3E)-nonen-2-one + H(+) + NADPH;
CC         Xref=Rhea:RHEA:50616, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783,
CC         ChEBI:CHEBI:58349, ChEBI:CHEBI:77927, ChEBI:CHEBI:133457;
CC         Evidence={ECO:0000256|ARBA:ARBA00023696};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50618;
CC         Evidence={ECO:0000256|ARBA:ARBA00023696};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=NADP(+) + octanal = (2E)-octenal + H(+) + NADPH;
CC         Xref=Rhea:RHEA:50780, ChEBI:CHEBI:15378, ChEBI:CHEBI:17935,
CC         ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:61748;
CC         Evidence={ECO:0000256|ARBA:ARBA00023504};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50782;
CC         Evidence={ECO:0000256|ARBA:ARBA00023504};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=NADP(+) + pentan-2-one = (E)-pent-3-en-2-one + H(+) + NADPH;
CC         Xref=Rhea:RHEA:50788, ChEBI:CHEBI:15378, ChEBI:CHEBI:16472,
CC         ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:145276;
CC         Evidence={ECO:0000256|ARBA:ARBA00024160};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50790;
CC         Evidence={ECO:0000256|ARBA:ARBA00024160};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an n-alkanal + NADP(+) = an alk-2-enal + H(+) + NADPH;
CC         Xref=Rhea:RHEA:13737, ChEBI:CHEBI:12834, ChEBI:CHEBI:13757,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.74;
CC         Evidence={ECO:0000256|ARBA:ARBA00023507};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:13739;
CC         Evidence={ECO:0000256|ARBA:ARBA00023507};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=decanal + NADP(+) = (2E)-decenal + H(+) + NADPH;
CC         Xref=Rhea:RHEA:50612, ChEBI:CHEBI:15378, ChEBI:CHEBI:31457,
CC         ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133455;
CC         Evidence={ECO:0000256|ARBA:ARBA00023691};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50614;
CC         Evidence={ECO:0000256|ARBA:ARBA00023691};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=dodecanal + NADP(+) = (2E)-dodecenal + H(+) + NADPH;
CC         Xref=Rhea:RHEA:50784, ChEBI:CHEBI:15378, ChEBI:CHEBI:27836,
CC         ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133741;
CC         Evidence={ECO:0000256|ARBA:ARBA00023530};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50786;
CC         Evidence={ECO:0000256|ARBA:ARBA00023530};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=hexanal + NADP(+) = (E)-hex-2-enal + H(+) + NADPH;
CC         Xref=Rhea:RHEA:50776, ChEBI:CHEBI:15378, ChEBI:CHEBI:28913,
CC         ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:88528;
CC         Evidence={ECO:0000256|ARBA:ARBA00034052};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50778;
CC         Evidence={ECO:0000256|ARBA:ARBA00034052};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=leukotriene B4 + NADP(+) = 12-oxo-leukotriene B4 + H(+) +
CC         NADPH; Xref=Rhea:RHEA:50608, ChEBI:CHEBI:15378, ChEBI:CHEBI:57461,
CC         ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133309;
CC         Evidence={ECO:0000256|ARBA:ARBA00023545};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50609;
CC         Evidence={ECO:0000256|ARBA:ARBA00023545};
CC   -!- SUBUNIT: Monomer or homodimer. {ECO:0000256|ARBA:ARBA00011852}.
CC   -!- SIMILARITY: Belongs to the NADP-dependent oxidoreductase L4BD family.
CC       {ECO:0000256|ARBA:ARBA00010460}.
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DR   EMBL; AGBW02000285; OWR55798.1; -; Genomic_DNA.
DR   RefSeq; XP_032517418.1; XM_032661527.1.
DR   RefSeq; XP_032517419.1; XM_032661528.1.
DR   EnsemblMetazoa; XM_032661527.1; XP_032517418.1; LOC116770165.
DR   EnsemblMetazoa; XM_032661528.1; XP_032517419.1; LOC116770165.
DR   KEGG; dpl:KGM_207815; -.
DR   eggNOG; KOG1196; Eukaryota.
DR   OrthoDB; 179761at2759; -.
DR   Proteomes; UP000007151; Unassembled WGS sequence.
DR   Proteomes; UP000596680; Chromosome 14.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0036132; F:13-prostaglandin reductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0047522; F:15-oxoprostaglandin 13-oxidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0032440; F:2-alkenal reductase [NAD(P)+] activity; IEA:UniProtKB-EC.
DR   CDD; cd08294; leukotriene_B4_DH_like; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR041694; ADH_N_2.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR045010; MDR_fam.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   InterPro; IPR014190; PTGR1.
DR   PANTHER; PTHR43205; PROSTAGLANDIN REDUCTASE; 1.
DR   PANTHER; PTHR43205:SF7; PROSTAGLANDIN REDUCTASE 1; 1.
DR   Pfam; PF16884; ADH_N_2; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; GroES-like; 2.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022501};
KW   Hydroxylation {ECO:0000256|ARBA:ARBA00023278};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022501};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Prostaglandin metabolism {ECO:0000256|ARBA:ARBA00022501};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007151}.
FT   DOMAIN          34..351
FT                   /note="Enoyl reductase (ER)"
FT                   /evidence="ECO:0000259|SMART:SM00829"
SQ   SEQUENCE   354 AA;  38806 MW;  24A893F62E4DE1C8 CRC64;
     MANIVPSTIA RGLSSGVANR ILAKKYVLTK HFEGEPKKSD FIVVEEELPQ LKDGEILTEA
     EYLSVDPYMR AYMIRFKMPA DMIGGQVAKV IESRSAKVPV GSYVTGSFGW RTHSIVNYDN
     PSADQQLPVH VLPDFGPYPV SLALGLLGMP GNTAYFGLKE LCQPKAGETL VVTGAAGAVG
     SHVGQIGKIL GCRVIGFAGS DEKCQYLKKE LGFDYAFNYK TANIRSALKE AAPNRVDCYF
     DNVGGEISSI IMSHMNKYGR VAVCGSISSY NDTTLPKVSI VQPSIVFNEL KLEGFIVSRW
     ANRWQEGIMA NLKWLKEGKL KYQEKVYHGF DNMVDALVGM LRGENTGKAV VKVK
//

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