ID A0A212QZ87_9CHLR Unreviewed; 761 AA.
AC A0A212QZ87;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=SAMN02746019_00009090 {ECO:0000313|EMBL:SNB65004.1};
OS Thermoflexus hugenholtzii JAD2.
OC Bacteria; Chloroflexota; Thermoflexia; Thermoflexales; Thermoflexaceae;
OC Thermoflexus.
OX NCBI_TaxID=877466 {ECO:0000313|EMBL:SNB65004.1, ECO:0000313|Proteomes:UP000197025};
RN [1] {ECO:0000313|Proteomes:UP000197025}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JAD2 {ECO:0000313|Proteomes:UP000197025};
RA Varghese N., Submissions S.;
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; FYEK01000027; SNB65004.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A212QZ87; -.
DR InParanoid; A0A212QZ87; -.
DR OrthoDB; 9790669at2; -.
DR Proteomes; UP000197025; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00075; HATPase; 1.
DR CDD; cd00082; HisKA; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR PANTHER; PTHR43711:SF31; SENSOR HISTIDINE KINASE GRAS; 1.
DR PANTHER; PTHR43711; TWO-COMPONENT HISTIDINE KINASE; 1.
DR Pfam; PF13185; GAF_2; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00065; GAF; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Kinase {ECO:0000313|EMBL:SNB65004.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000313|EMBL:SNB65004.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 47..68
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 80..100
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 107..127
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 158..176
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 211..233
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 245..269
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 281..299
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 516..757
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT COILED 475..509
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 761 AA; 83725 MW; F4066328BF627403 CRC64;
MVNWTPGFPV LSGVQIGVIL ALGWAVWQMG LLARMAGGRE EGLPWEAWVY SGLGILWQGL
WAVAIWQGVP PLIRFTAWNL AGWALSLLPM GLLLWIGWFL ERPLPRWAIL LMGLGAGVTL
IAATLPYRPE TGPALSAWWN ARRIPGDLVL WSWGIREGIW GIGTALGLGW LGWAYLHIPR
PLHRNRVAYE FLGTGLVALG EGLAWTPRSD WIALGWGVRG IGVTILALPM GWLELPSLRQ
VGRSLLAWGL SAILQIGLIL GILAGAAALR TSLPGVVPVG LEWGGIALAI VLAQWWIGWP
LHRWLRRRLL PAVDEPAAAV RRYGQTISNL LDVEALAQAA FTVLQETFGL RQGVLLLFEE
QPDASLQARV IRGLGEAPDD PGRFAPDSPI LRAWQEGRSL TQYEIDFGKA FQRADPAERR
WLQRLGVELF VPIRAQAVLL GCLALGARSG AEAYSSADRD LLASMAEQTA AVLQNIRLVE
DLRRLNARMA ELNEDLARAA RRLEKLDRVK THFIEIASHE LRTPLTHIRG YADLLAETLS
GQDEPNGSLE RILQGLRRAA LRLEEIISAM LDVSQIDAEA LSIYPISIQI PTLVRMAVEP
LEGAIAERRQ KLVVEPMEDL PVIYGDLTRL VQALRHVVQN AIKFTPDGGT ITLRARRVPA
EEAGSSTDYV EIAVQDTGIG IDPEDQALIF EKFYRVGPIE RHSTGAIKFK GAGPGLGLPL
ARGIIEAHGG RIWVESPGYD EVRCPGSTFY IWLPVVSRSE D
//
