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Database: UniProt
Entry: A0A212R8Y7_9CHLR
LinkDB: A0A212R8Y7_9CHLR
Original site: A0A212R8Y7_9CHLR 
ID   A0A212R8Y7_9CHLR        Unreviewed;       418 AA.
AC   A0A212R8Y7;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   31-JUL-2019, entry version 13.
DE   RecName: Full=Prephenate dehydratase {ECO:0000256|RuleBase:RU361254};
DE            Short=PDT {ECO:0000256|RuleBase:RU361254};
DE            EC=4.2.1.51 {ECO:0000256|RuleBase:RU361254};
GN   Name=pheA {ECO:0000256|RuleBase:RU361254};
GN   ORFNames=SAMN02746019_00014150 {ECO:0000313|EMBL:SNB68651.1};
OS   Thermoflexus hugenholtzii JAD2.
OC   Bacteria; Chloroflexi; Thermoflexia; Thermoflexales; Thermoflexaceae;
OC   Thermoflexus.
OX   NCBI_TaxID=877466 {ECO:0000313|EMBL:SNB68651.1, ECO:0000313|Proteomes:UP000197025};
RN   [1] {ECO:0000313|Proteomes:UP000197025}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JAD2 {ECO:0000313|Proteomes:UP000197025};
RA   Varghese N., Submissions S.;
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O;
CC         Xref=Rhea:RHEA:21648, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:18005, ChEBI:CHEBI:29934;
CC         EC=4.2.1.51; Evidence={ECO:0000256|RuleBase:RU361254};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=chorismate = prephenate; Xref=Rhea:RHEA:13897,
CC         ChEBI:CHEBI:29748, ChEBI:CHEBI:29934; EC=5.4.99.5;
CC         Evidence={ECO:0000256|PROSITE-ProRule:PRU00514};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-phenylalanine biosynthesis;
CC       phenylpyruvate from prephenate: step 1/1.
CC       {ECO:0000256|RuleBase:RU361254}.
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DR   EMBL; FYEK01000037; SNB68651.1; -; Genomic_DNA.
DR   UniPathway; UPA00121; UER00345.
DR   Proteomes; UP000197025; Unassembled WGS sequence.
DR   GO; GO:0004106; F:chorismate mutase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004664; F:prephenate dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009094; P:L-phenylalanine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd02185; AroH; 1.
DR   Gene3D; 3.30.1330.40; -; 1.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR008243; Chorismate_mutase_AroH.
DR   InterPro; IPR001086; Preph_deHydtase.
DR   InterPro; IPR018528; Preph_deHydtase_CS.
DR   InterPro; IPR035959; RutC-like_sf.
DR   Pfam; PF07736; CM_1; 1.
DR   Pfam; PF00800; PDT; 1.
DR   SUPFAM; SSF55298; SSF55298; 1.
DR   TIGRFAMs; TIGR01796; CM_mono_aroH; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS51167; CHORISMATE_MUT_1; 1.
DR   PROSITE; PS00858; PREPHENATE_DEHYDR_2; 1.
DR   PROSITE; PS51171; PREPHENATE_DEHYDR_3; 1.
PE   4: Predicted;
KW   Amino-acid biosynthesis {ECO:0000256|PROSITE-ProRule:PRU00514,
KW   ECO:0000256|RuleBase:RU361254};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PROSITE-
KW   ProRule:PRU00514, ECO:0000256|RuleBase:RU361254};
KW   Complete proteome {ECO:0000313|Proteomes:UP000197025};
KW   Isomerase {ECO:0000256|PROSITE-ProRule:PRU00514};
KW   Lyase {ECO:0000256|RuleBase:RU361254};
KW   Phenylalanine biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Reference proteome {ECO:0000313|Proteomes:UP000197025}.
FT   DOMAIN      138    314       Prephenate dehydratase.
FT                                {ECO:0000259|PROSITE:PS51171}.
FT   DOMAIN      326    403       ACT. {ECO:0000259|PROSITE:PS51671}.
FT   REGION      116    136       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
SQ   SEQUENCE   418 AA;  45512 MW;  7C270649E3AE9AA8 CRC64;
     MICGIRGAIT AQANTPEAIA SATRTLLQAI ARANHLAPDE IVAAWFTTTP DLNAAFPAAV
     AREMGWTHVP MLCAQEIPVP DGLPRCIRVL LLVQPRRPLQ PVPVYLGEAR RLRPDLFNGE
     GDPAPEPDPP PPTLTRPRVA FQGEPGAYSH EAAERFFGGE LELLPCTTFA EVAQAVEAGR
     ADFGILPVEN STAGSINAVY DLLLERDLRI WGEVILRVRH CLLAPPGTSL SDIRAVRSHP
     QALEQCARFI ARHGWEAIAA PDTAGSARML AERPEPGVAA IASRLAAERY SLAILAEGIE
     DDPENATRFF IVSTYEPPRA ARNKTSIVFS TRHVPGALHA CLGEFAARGI NLTKLESRPR
     RGRPWEYVFY VDFEGHWQDP ACREALLGLL QRASFLKLLG SYPAAEGTVS SHEEGGER
//
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