ID   A0A212T0Q4_9ACTN        Unreviewed;       984 AA.
AC   A0A212T0Q4;
DT   25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2017, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Histidine kinase-like ATPase domain-containing protein {ECO:0000313|EMBL:SNC59623.1};
GN   ORFNames=SAMN06272741_0097 {ECO:0000313|EMBL:SNC59623.1};
OS   Streptomyces sp. 2114.4.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1938836 {ECO:0000313|EMBL:SNC59623.1, ECO:0000313|Proteomes:UP000198141};
RN   [1] {ECO:0000313|Proteomes:UP000198141}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2114.4 {ECO:0000313|Proteomes:UP000198141};
RA   Varghese N., Submissions S.;
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FYEY01000001; SNC59623.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A212T0Q4; -.
DR   Proteomes; UP000198141; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004673; F:protein histidine kinase activity; IEA:UniProtKB-EC.
DR   CDD; cd16936; HATPase_RsbW-like; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 2.
DR   Gene3D; 3.60.40.10; PPM-type phosphatase domain; 1.
DR   InterPro; IPR003018; GAF.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR036457; PPM-type-like_dom_sf.
DR   InterPro; IPR001932; PPM-type_phosphatase-like_dom.
DR   InterPro; IPR033463; sCache_3.
DR   InterPro; IPR029151; Sensor-like_sf.
DR   PANTHER; PTHR43156:SF2; MULTIDOMAIN REGULATORY PROTEIN RV1364C; 1.
DR   PANTHER; PTHR43156; STAGE II SPORULATION PROTEIN E-RELATED; 1.
DR   Pfam; PF01590; GAF; 1.
DR   Pfam; PF13581; HATPase_c_2; 1.
DR   Pfam; PF17203; sCache_3_2; 1.
DR   Pfam; PF07228; SpoIIE; 1.
DR   SMART; SM00065; GAF; 1.
DR   SMART; SM00091; PAS; 1.
DR   SMART; SM00331; PP2C_SIG; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF55781; GAF domain-like; 1.
DR   SUPFAM; SSF81606; PP2C-like; 1.
DR   SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR   SUPFAM; SSF103190; Sensory domain-like; 1.
PE   4: Predicted;
KW   Kinase {ECO:0000313|EMBL:SNC59623.1}; Membrane {ECO:0000256|SAM:Phobius};
KW   Transferase {ECO:0000313|EMBL:SNC59623.1};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        99..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        256..277
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          298..363
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|SMART:SM00091"
FT   DOMAIN          418..593
FT                   /note="GAF"
FT                   /evidence="ECO:0000259|SMART:SM00065"
FT   DOMAIN          611..832
FT                   /note="PPM-type phosphatase"
FT                   /evidence="ECO:0000259|SMART:SM00331"
FT   REGION          1..87
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   984 AA;  104950 MW;  EF053EE792F8A064 CRC64;
     MSGNPGRFRR WLSHAPGRSA IPGTPPAGDS TGDDQQGERT AEAGDPTEEG GLTGDGVPTE
     ARGPADTGGP PQGEPPASAG GPQHIRPSLT TRSVAGEVFL LQLVLVVLLV AAAVVALVVQ
     ARRDTMTDAR HRTLAAAESF AHSWGLQEAL NSDNPSAKLQ PLAEAARKAS GVDALIVYKL
     DGITLTHSDP RQIGKHVIGP YAEAARGKPF TRTFQGALGL SVVSAAPVKD ASGRVVALVA
     APVTVEKVQK SVNRQLPMFL GTAAVALALA GGGAGLVSRR LRRQTHGLGP AEMTRMYEHH
     DAVLHAVREG VLIVGPDGRL LLANDEARRL LDLPAEAEGR HVGDLGLDHR TAGLLASDRS
     ATDEVHLAQD RLLALNKRST TAHGARQGSV VTLRDTTELR WLSGRAEVAR ERLRLLYDAG
     VRIGSTLNVV RTAEELAQVA VPRFADIVTV ELLDPVLKGE EPAVAGTELR RAALAGLAPD
     HPLYPVGELI RFVPEPPVGA HRGRIRSMVE PDLAGSSAWR SQDPERTRRI LDHGVHSLAV
     VPLRARGVVL GLVDFWRSGG TPPFDDEDLS FAEELAGRAA VGIDNARRYT RERTMAMTLQ
     RSLMPRGLPD QDILEVAHRY LPARAGVGGD WFDVIPLPGA RVALVVGDVV GHGVHAAATM
     GRLRIAVHNF SALDLSPDEL LGHLDELVTH LDVQDEDNDE GPAITGATCL YVIYDSVSGR
     VTAATAGHPP PAVAYPDGTV EFLHPPVSPP LGLSTGLPFE STELSLPKGS RLVLYTDGLI
     ESRSRDLDAG LEALRAALAG PDRTPEDTCA AVMQALLPAR PADDVALLVA RPRRLGPADV
     AEWDVPRDPA AVGPVRNACV RRLEDWGLQH IAYGTELILS ELITNAIRYG AEPIHVRLLR
     TRGTLISEVS DGSSTSPHIR QAKATDENGR GLFLVAQFAE RWGTRYSPRG KTIWASQAIA
     PDALPPEEES PDHLLSRWEQ LGGW
//