ID   A0A212T4X0_9ACTN        Unreviewed;       561 AA.
AC   A0A212T4X0;
DT   25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2017, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Acetyl-CoA synthetase {ECO:0000313|EMBL:SNC61113.1};
GN   ORFNames=SAMN06272741_0413 {ECO:0000313|EMBL:SNC61113.1};
OS   Streptomyces sp. 2114.4.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1938836 {ECO:0000313|EMBL:SNC61113.1, ECO:0000313|Proteomes:UP000198141};
RN   [1] {ECO:0000313|Proteomes:UP000198141}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2114.4 {ECO:0000313|Proteomes:UP000198141};
RA   Varghese N., Submissions S.;
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC       {ECO:0000256|ARBA:ARBA00006432}.
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DR   EMBL; FYEY01000001; SNC61113.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A212T4X0; -.
DR   Proteomes; UP000198141; Unassembled WGS sequence.
DR   GO; GO:0016878; F:acid-thiol ligase activity; IEA:UniProt.
DR   GO; GO:0016405; F:CoA-ligase activity; IEA:UniProt.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   PANTHER; PTHR43605:SF10; ACYL-COA SYNTHETASE MEDIUM CHAIN FAMILY MEMBER 3; 1.
DR   PANTHER; PTHR43605; ACYL-COENZYME A SYNTHETASE; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   3: Inferred from homology;
KW   Ligase {ECO:0000256|ARBA:ARBA00022598}.
FT   DOMAIN          55..407
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
FT   DOMAIN          458..535
FT                   /note="AMP-binding enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13193"
SQ   SEQUENCE   561 AA;  61396 MW;  01391EE153FE4FBC CRC64;
     MIGDKLSGQD DAYQEFRAAR DLLLHHANDQ DAARKAFRWP RPRQFNWATD WFDRIAEGND
     RVALRIVGQG ELTFQELSRR SDRVAGWLLS QGIRRGDVVM LLMDNRTELW ELMLALIKVR
     AVIAPAFITI SPEELRTRIG RAGATHVIAD HRIVPGLAVD GLRTRIIVGG EHEGWVDFAT
     SAEHEGGFVP EGPTEADEPL FYYFTSGSTS RPKLVVHTHV SYAIGHLASM YWNGLKPGDV
     HLNVSAPAWA KYPWSSLFGP WNAEATVVSM DNADATPQRL LEVLRTGTVT SFCAPPSIWR
     ALIRTGLPDG LPGLRHAVSV GEPLMGDVVE QVRRLAGVTV RNGFGQSEVT AMAGVTASSP
     ADPVSMGYPL PGYELVVVRP GTDEPAQEGE LCLDLANKPV GMMRGYLDPE DNATSHTPGG
     LYRTGDLARW DSDGSLVYLG RGKDVFEGPD GALIAPLELE HVLVLHPAVA ELSVVPVSED
     TAQVPKAYVV LSAGWNASRA TAEVLFAHLQ KHLPAPRHVR FLEFVDDLPR TESGKVQREA
     VRRLRRSRNV EFAVGPPAAL A
//