ID A0A212T7Y8_9MICO Unreviewed; 1055 AA.
AC A0A212T7Y8;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=SAMN05445756_0595 {ECO:0000313|EMBL:SNC61980.1};
OS Kytococcus aerolatus.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Kytococcaceae;
OC Kytococcus.
OX NCBI_TaxID=592308 {ECO:0000313|EMBL:SNC61980.1, ECO:0000313|Proteomes:UP000198122};
RN [1] {ECO:0000313|EMBL:SNC61980.1, ECO:0000313|Proteomes:UP000198122}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22179 {ECO:0000313|EMBL:SNC61980.1,
RC ECO:0000313|Proteomes:UP000198122};
RA Kim H.J., Triplett B.A.;
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; FYEZ01000001; SNC61980.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A212T7Y8; -.
DR OrthoDB; 5240387at2; -.
DR Proteomes; UP000198122; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF59; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000198122}.
FT DOMAIN 1..287
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 284..607
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 10..17
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1055 AA; 110824 MW; D86C02CFC25C529E CRC64;
MTASVELVLG APGTGTSQRA VQEVIQHVTG GGRLEEVLVL APTRAAATDL RERLEAELGV
AATGMPVHSH QAFGFAVLAQ RARREGLPAP TLLSGADQDA VLAELLQSST GAGHPWPEEV
VPALGTQGFR DELRDLFARA VEHGVTASEL AALDDHQGEH GTPGLWRAAA SLMTEFERVT
ALAAPAAVDA AWVVAAAADL LLVEDDLATQ VLGPLRLVVV DDAQELTVGT HRLLTAALAG
VSGRAVLLGD PDAATQGFRG ARPELFVDWA RSQGASVEVL EQGHRLGPGL AAVAERITGR
VGAATVAHRT PAPAARRGGA EALVLPSPHV EAVRIATELR REHVLGEVPW GRMAVVVRGR
AQSGRVRRAL ERAGVPVQVT GGGQPLTGHP VVSVLIDLLE AAVHAARTGD LSVDEERALA
WLGSPLGGLD AAGVRRLRRL LLAGVGEQEG AAPVTSGELL VAALTEPPEV WEGRGAELGP
LRRLATALTR GVEAARRTGG RSGDGRAGGP GVTAEEVLWA VWDGLGVADR WQRTALEGGV
AGRRADSDLD AVMSLFALAE QFTERRPGAG PEVFVETVSS SGVARDSLVL GARRDAVQML
TPQTAAGGQW EVVLVAGVQA GAWPDLRLRG SLLGAGRLVD LVEGRHGELS DQIAAVRHDE
TRQFLVACTR ATRRLVVTAV RDAEEQPSPF LDLVDPLPPG VETRPVSAWV PPLDLPTQVA
RARRELLLAA GAPGPRARPT GTEGPTDGAR QERGIEQVDA SRRAAWAGEL VTLARAGVGA
ADPDRWWLGR RPSSAAPPWP EGTLAVARPS ALGTWQDCAL KGFLTAHGGQ SPAGPQQELG
ILVHDVLADH PEAPVRELEA AVDAQWEEFG SPEVWWSRRD RERLSEWLRR YDTYRHECGR
ELVATEVPLD VTVGGVRLVG RVDRVERHPD SGALHVADLK SGQVGSPKEL PENPQLGAYQ
VAVEAGGLQV VAPDAGTAAV SGGASLVQLA EGQTIRTIDR RQAALAAGEV DHAARLQETG
REMLAATHLA TVGDACRHCP VRTSCPAQPE GGQVA
//
