ID   A0A212TT08_9ACTN        Unreviewed;       343 AA.
AC   A0A212TT08;
DT   25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2017, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=O-methyltransferase {ECO:0000313|EMBL:SNC69040.1};
GN   ORFNames=SAMN06272741_2878 {ECO:0000313|EMBL:SNC69040.1};
OS   Streptomyces sp. 2114.4.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1938836 {ECO:0000313|EMBL:SNC69040.1, ECO:0000313|Proteomes:UP000198141};
RN   [1] {ECO:0000313|Proteomes:UP000198141}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2114.4 {ECO:0000313|Proteomes:UP000198141};
RA   Varghese N., Submissions S.;
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FYEY01000001; SNC69040.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A212TT08; -.
DR   OrthoDB; 4145676at2; -.
DR   Proteomes; UP000198141; Unassembled WGS sequence.
DR   GO; GO:0008171; F:O-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR016461; COMT-like.
DR   InterPro; IPR001077; O_MeTrfase_dom.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR43712:SF2; O-METHYLTRANSFERASE CICE; 1.
DR   PANTHER; PTHR43712; PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED; 1.
DR   Pfam; PF00891; Methyltransf_2; 1.
DR   PIRSF; PIRSF005739; O-mtase; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS51683; SAM_OMT_II; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000313|EMBL:SNC69040.1};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000313|EMBL:SNC69040.1}.
FT   DOMAIN          122..324
FT                   /note="O-methyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF00891"
FT   ACT_SITE        253
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005739-1"
SQ   SEQUENCE   343 AA;  36988 MW;  7598BF73DF39622E CRC64;
     MASSPTPPTG EPRDFAAHLM EQAMGHVFSA ALRTAAHHRL ADHLAAGPRT PEQLAAATGT
     HAPHLHRVLR YLATRGFFRE DTAGAYHLTP AAVPLRTDVP DSMHPAVMMA TDELFLRTSA
     ALPEAVRHEG ASFERLFGAP LFEHLTTDPA TRRVFDDGMS SVSAPVDAAV ADVYPFPAEG
     TVVDVGGGRG GLLRAALRRH PQLTGVLFDQ APPLAHHLLE GDELKGRWRT QEGDFFASVP
     EGGDVYVLKH VLHDWPDDAC LRILRSCRRA MAAGRRLLVI DAVLPPGNAP HFGKTLDVAM
     MAVVDGRERT TEEFATLLSA GGFRLTRVLP TPAFPSIVEA VAE
//