ID A0A218KNB9_9RICK Unreviewed; 605 AA.
AC A0A218KNB9;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=UvrABC system protein C {ECO:0000256|HAMAP-Rule:MF_00203};
DE Short=Protein UvrC {ECO:0000256|HAMAP-Rule:MF_00203};
DE AltName: Full=Excinuclease ABC subunit C {ECO:0000256|HAMAP-Rule:MF_00203};
GN Name=uvrC {ECO:0000256|HAMAP-Rule:MF_00203};
GN ORFNames=ASM33_02705 {ECO:0000313|EMBL:APR98197.1};
OS Wolbachia endosymbiont of Folsomia candida.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rickettsiales;
OC Anaplasmataceae; Wolbachieae; Wolbachia.
OX NCBI_TaxID=169402 {ECO:0000313|EMBL:APR98197.1, ECO:0000313|Proteomes:UP000247300};
RN [1] {ECO:0000313|EMBL:APR98197.1, ECO:0000313|Proteomes:UP000247300}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berlin {ECO:0000313|EMBL:APR98197.1,
RC ECO:0000313|Proteomes:UP000247300};
RX PubMed=28659179; DOI=10.1186/s12864-017-3852-x;
RA Faddeeva-Vakhrusheva A., Kraaijeveld K., Derks M.F.L., Anvar S.Y.,
RA Agamennone V., Suring W., Kampfraath A.A., Ellers J., Le Ngoc G.,
RA van Gestel C.A.M., Marien J., Smit S., van Straalen N.M., Roelofs D.;
RT "Coping with living in the soil: the genome of the parthenogenetic
RT springtail Folsomia candida.";
RL BMC Genomics 18:493-493(2017).
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC lesion. The N-terminal half is responsible for the 3' incision and the
CC C-terminal half is responsible for the 5' incision. {ECO:0000256|HAMAP-
CC Rule:MF_00203}.
CC -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC {ECO:0000256|HAMAP-Rule:MF_00203}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00203}.
CC -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000256|HAMAP-
CC Rule:MF_00203}.
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DR EMBL; CP015510; APR98197.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A218KNB9; -.
DR KEGG; weo:ASM33_02705; -.
DR OrthoDB; 9804933at2; -.
DR Proteomes; UP000247300; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR CDD; cd10434; GIY-YIG_UvrC_Cho; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.1440.10; GIY-YIG endonuclease; 1.
DR Gene3D; 3.30.420.340; UvrC, RNAse H endonuclease domain; 1.
DR HAMAP; MF_00203; UvrC; 1.
DR InterPro; IPR000305; GIY-YIG_endonuc.
DR InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR InterPro; IPR047296; GIY-YIG_UvrC_Cho.
DR InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR001943; UVR_dom.
DR InterPro; IPR036876; UVR_dom_sf.
DR InterPro; IPR004791; UvrC.
DR InterPro; IPR001162; UvrC_RNase_H_dom.
DR InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR NCBIfam; TIGR00194; uvrC; 1.
DR PANTHER; PTHR30562:SF1; UVRABC SYSTEM PROTEIN C; 1.
DR PANTHER; PTHR30562; UVRC/OXIDOREDUCTASE; 1.
DR Pfam; PF01541; GIY-YIG; 1.
DR Pfam; PF14520; HHH_5; 1.
DR Pfam; PF02151; UVR; 1.
DR Pfam; PF08459; UvrC_RNaseH_dom; 1.
DR SMART; SM00465; GIYc; 1.
DR SMART; SM00278; HhH1; 2.
DR SUPFAM; SSF46600; C-terminal UvrC-binding domain of UvrB; 1.
DR SUPFAM; SSF82771; GIY-YIG endonuclease; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 1.
DR PROSITE; PS50164; GIY_YIG; 1.
DR PROSITE; PS50151; UVR; 1.
DR PROSITE; PS50165; UVRC; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00203};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00203};
KW DNA excision {ECO:0000256|ARBA:ARBA00022769, ECO:0000256|HAMAP-
KW Rule:MF_00203};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00203};
KW Excision nuclease {ECO:0000256|ARBA:ARBA00022881, ECO:0000256|HAMAP-
KW Rule:MF_00203};
KW SOS response {ECO:0000256|ARBA:ARBA00023236, ECO:0000256|HAMAP-
KW Rule:MF_00203}.
FT DOMAIN 19..97
FT /note="GIY-YIG"
FT /evidence="ECO:0000259|PROSITE:PS50164"
FT DOMAIN 207..242
FT /note="UVR"
FT /evidence="ECO:0000259|PROSITE:PS50151"
FT DOMAIN 257..479
FT /note="UvrC family homology region profile"
FT /evidence="ECO:0000259|PROSITE:PS50165"
SQ SEQUENCE 605 AA; 69476 MW; 937053DCD0583E20 CRC64;
MGYVINVQAI EEQIKLSPQS CGVYKMIGDK NKALYVGKAK KLKSRLSSYL QFENLSERIR
VMLSQVIKVE IFITENEIEA LLLESQLIKS LKPTYNIVLT DGKSYPYITI SKHVYPRIAK
YRGKFKKDEF YYYGPFPSAA AVKNTILSLQ KAFLLRVCSD QYFSSTKRPC IEYQIKRCSA
PCVNKITKED YCQSMKQAQD TLLGRNKEVQ KQLLSTMEKC SSEMNYELAA VYRDRVKFLQ
QIQMKAVDFS FEEDADFFSI AREEDLACIN VLSFRNKCNY GSVPYFVENC GDHSNNEILS
TFLVNLYNPI NIPQDKIYVP DFVTDNEIIE QALQKITHKS IKVLHTKSNE ERDLLKFVYN
NSQHSLEQKL IEYKNNLEKL EDLSKIFSLS NIPKRIEVYD NSHISGNQQV GVMVVAGQEG
LLKSEYRKFT IKEEISADDY KMMKEVLTRR FSGKIKDIIP DFLLIDGGPG HVSIVQDVLQ
TLNINVPFAC MAKGPDRNTG NERFYMPNRE EFSLENDSKV MLYLQSLRNE AHRFAITTHR
KKRDKQFIVS SLSKIPGIGN KRKKALMSYF GSVENMSKAS LAEIQNVSGI SKGLAEIILK
HVNGR
//
