ID A0A218NMF4_9ARCH Unreviewed; 453 AA.
AC A0A218NMF4;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=asparagine--tRNA ligase {ECO:0000256|ARBA:ARBA00012816};
DE EC=6.1.1.22 {ECO:0000256|ARBA:ARBA00012816};
GN ORFNames=Mia14_0319 {ECO:0000313|EMBL:ASI13646.1};
OS Candidatus Mancarchaeum acidiphilum.
OC Archaea; Candidatus Micrarchaeota; Candidatus Mancarchaeum.
OX NCBI_TaxID=1920749 {ECO:0000313|EMBL:ASI13646.1, ECO:0000313|Proteomes:UP000197679};
RN [1] {ECO:0000313|EMBL:ASI13646.1, ECO:0000313|Proteomes:UP000197679}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mia14 {ECO:0000313|EMBL:ASI13646.1,
RC ECO:0000313|Proteomes:UP000197679};
RX PubMed=28680072; DOI=10.1038/s41467-017-00104-7;
RA Golyshina O., Toshchakov S., Makarova K., Gavrilov S., Korzhenkov A.,
RA La Cono V., Arcadi E., Nechitaylo T., Ferrer M., Kublanov I., Wolf Y.,
RA Yakimov M., Golyshin P., Slesarev A., Kozyavkin S.;
RT "'ARMAN' archaea depend on association with euryarchaeal host in culture
RT and in situ.";
RL Nat. Commun. 8:60-60(2017).
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DR EMBL; CP019964; ASI13646.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A218NMF4; -.
DR KEGG; marh:Mia14_0319; -.
DR OrthoDB; 5908at2157; -.
DR Proteomes; UP000197679; Chromosome.
DR GO; GO:0004816; F:asparagine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006421; P:asparaginyl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd00776; AsxRS_core; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR004364; Aa-tRNA-synt_II.
DR InterPro; IPR006195; aa-tRNA-synth_II.
DR InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR InterPro; IPR004522; Asn-tRNA-ligase.
DR InterPro; IPR002312; Asp/Asn-tRNA-synth_IIb.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR004365; NA-bd_OB_tRNA.
DR NCBIfam; TIGR00457; asnS; 1.
DR PANTHER; PTHR22594:SF34; ASPARAGINE--TRNA LIGASE, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR22594; ASPARTYL/LYSYL-TRNA SYNTHETASE; 1.
DR Pfam; PF00152; tRNA-synt_2; 1.
DR Pfam; PF01336; tRNA_anti-codon; 1.
DR PRINTS; PR01042; TRNASYNTHASP.
DR SUPFAM; SSF55681; Class II aaRS and biotin synthetases; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR PROSITE; PS50862; AA_TRNA_LIGASE_II; 1.
PE 4: Predicted;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000313|EMBL:ASI13646.1}; ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000197679}.
FT DOMAIN 154..443
FT /note="Aminoacyl-transfer RNA synthetases class-II family
FT profile"
FT /evidence="ECO:0000259|PROSITE:PS50862"
SQ SEQUENCE 453 AA; 52125 MW; 8B2558A13F183056 CRC64;
MKDEKSLKSV HLSSLLEKGL EHSEKYATSV SDLRKKIGEE VFLRGWVYRH RRTGNMAFVV
LRDGTGIVQC SVNKDNVKPD EWESANDLYI DSVVNLIGEV REDDRAPDGI EVQVREFGVA
FKGEPFPITK DQSTEFLLDM RHLWIRSPKM IDILKLKASV INDIRGFLDE KGFLEVQPPL
ITGSAAEGGA TLFEVNYFDR KAYLSQSGQL YLEAVINGYP LVYGFAPSFR AEPSRTPRHL
AEFWQLEAEM AFYNQDMNMK LQEQILEHVA HSEAKNHPDI LKRFGRDPQD LLDIQTPFER
MKYEKALDIL KEKGLDVKWS DGLGMDEEKA LMQDRKQPVF LTNQPKEIRA FYMRINPDDP
RTVLDADLLA PEGIGEIFGG SERVSDYDEL MGRIKEQNLK EEDYQWYIDL RKYGSIPHSG
FGIGSERVVR WILKLDSIRD AIPFPRTMNR ISP
//
