ID A0A218NMV0_9ARCH Unreviewed; 138 AA.
AC A0A218NMV0;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=Ribonuclease VapC {ECO:0000256|HAMAP-Rule:MF_00265};
DE Short=RNase VapC {ECO:0000256|HAMAP-Rule:MF_00265};
DE EC=3.1.-.- {ECO:0000256|HAMAP-Rule:MF_00265};
DE AltName: Full=Putative toxin VapC {ECO:0000256|HAMAP-Rule:MF_00265};
GN Name=vapC {ECO:0000256|HAMAP-Rule:MF_00265};
GN ORFNames=Mia14_0466 {ECO:0000313|EMBL:ASI13783.1};
OS Candidatus Mancarchaeum acidiphilum.
OC Archaea; Candidatus Micrarchaeota; Candidatus Mancarchaeum.
OX NCBI_TaxID=1920749 {ECO:0000313|EMBL:ASI13783.1, ECO:0000313|Proteomes:UP000197679};
RN [1] {ECO:0000313|EMBL:ASI13783.1, ECO:0000313|Proteomes:UP000197679}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mia14 {ECO:0000313|EMBL:ASI13783.1,
RC ECO:0000313|Proteomes:UP000197679};
RX PubMed=28680072; DOI=10.1038/s41467-017-00104-7;
RA Golyshina O., Toshchakov S., Makarova K., Gavrilov S., Korzhenkov A.,
RA La Cono V., Arcadi E., Nechitaylo T., Ferrer M., Kublanov I., Wolf Y.,
RA Yakimov M., Golyshin P., Slesarev A., Kozyavkin S.;
RT "'ARMAN' archaea depend on association with euryarchaeal host in culture
RT and in situ.";
RL Nat. Commun. 8:60-60(2017).
CC -!- FUNCTION: Toxic component of a toxin-antitoxin (TA) system. An RNase.
CC {ECO:0000256|HAMAP-Rule:MF_00265}.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_00265};
CC -!- SIMILARITY: Belongs to the PINc/VapC protein family.
CC {ECO:0000256|HAMAP-Rule:MF_00265}.
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DR EMBL; CP019964; ASI13783.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A218NMV0; -.
DR KEGG; marh:Mia14_0466; -.
DR Proteomes; UP000197679; Chromosome.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004540; F:RNA nuclease activity; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR CDD; cd09873; PIN_Pae0151-like; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR HAMAP; MF_00265; VapC_Nob1; 1.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR002716; PIN_dom.
DR InterPro; IPR044153; PIN_Pae0151-like.
DR InterPro; IPR022907; VapC_family.
DR PANTHER; PTHR35901:SF1; EXONUCLEASE VAPC9; 1.
DR PANTHER; PTHR35901; RIBONUCLEASE VAPC3; 1.
DR Pfam; PF01850; PIN; 1.
DR SUPFAM; SSF88723; PIN domain-like; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00265};
KW Magnesium {ECO:0000256|HAMAP-Rule:MF_00265};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|HAMAP-
KW Rule:MF_00265};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|HAMAP-Rule:MF_00265};
KW Reference proteome {ECO:0000313|Proteomes:UP000197679};
KW Toxin {ECO:0000256|HAMAP-Rule:MF_00265};
KW Toxin-antitoxin system {ECO:0000256|ARBA:ARBA00022649, ECO:0000256|HAMAP-
KW Rule:MF_00265}.
FT DOMAIN 2..127
FT /note="PIN"
FT /evidence="ECO:0000259|Pfam:PF01850"
FT BINDING 5
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00265"
FT BINDING 103
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00265"
SQ SEQUENCE 138 AA; 15415 MW; E70FBC2B68CDB2B0 CRC64;
MMVLDASAIV KLIINESESD FVRKKVVSEA KKSEPIYTPD IALAESLNVI WKYSSLKSQN
NINQYKLLSD LMLLWNTLTV VNTATLASLA MKIAVDNKIT IYDALYAALS KLENAPLLTF
DKYLKSKATD IEIKVVTI
//
