ID   A0A218NN23_9ARCH        Unreviewed;       321 AA.
AC   A0A218NN23;
DT   27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT   27-SEP-2017, sequence version 1.
DT   24-JAN-2024, entry version 14.
DE   SubName: Full=2-oxoacid dehydrogenase multienzyme complex, 2-oxoacid decarboxylase (E1) component subunit beta {ECO:0000313|EMBL:ASI13863.1};
GN   ORFNames=Mia14_0550 {ECO:0000313|EMBL:ASI13863.1};
OS   Candidatus Mancarchaeum acidiphilum.
OC   Archaea; Candidatus Micrarchaeota; Candidatus Mancarchaeum.
OX   NCBI_TaxID=1920749 {ECO:0000313|EMBL:ASI13863.1, ECO:0000313|Proteomes:UP000197679};
RN   [1] {ECO:0000313|EMBL:ASI13863.1, ECO:0000313|Proteomes:UP000197679}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mia14 {ECO:0000313|EMBL:ASI13863.1,
RC   ECO:0000313|Proteomes:UP000197679};
RX   PubMed=28680072; DOI=10.1038/s41467-017-00104-7;
RA   Golyshina O., Toshchakov S., Makarova K., Gavrilov S., Korzhenkov A.,
RA   La Cono V., Arcadi E., Nechitaylo T., Ferrer M., Kublanov I., Wolf Y.,
RA   Yakimov M., Golyshin P., Slesarev A., Kozyavkin S.;
RT   "'ARMAN' archaea depend on association with euryarchaeal host in culture
RT   and in situ.";
RL   Nat. Commun. 8:60-60(2017).
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
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DR   EMBL; CP019964; ASI13863.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A218NN23; -.
DR   KEGG; marh:Mia14_0550; -.
DR   Proteomes; UP000197679; Chromosome.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0006082; P:organic acid metabolic process; IEA:UniProt.
DR   GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR   GO; GO:0044272; P:sulfur compound biosynthetic process; IEA:UniProt.
DR   CDD; cd07036; TPP_PYR_E1-PDHc-beta_like; 1.
DR   Gene3D; 3.40.50.920; -; 1.
DR   Gene3D; 3.40.50.970; -; 1.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR009014; Transketo_C/PFOR_II.
DR   InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR   InterPro; IPR033248; Transketolase_C.
DR   PANTHER; PTHR42980:SF1; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR42980; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED; 1.
DR   Pfam; PF02779; Transket_pyr; 1.
DR   Pfam; PF02780; Transketolase_C; 1.
DR   SMART; SM00861; Transket_pyr; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
DR   SUPFAM; SSF52922; TK C-terminal domain-like; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000197679}.
FT   DOMAIN          3..178
FT                   /note="Transketolase-like pyrimidine-binding"
FT                   /evidence="ECO:0000259|SMART:SM00861"
SQ   SEQUENCE   321 AA;  34941 MW;  8BFD1DB6B58C90A7 CRC64;
     MMANMISALN NALDLCLAEN EDIVIMGEDV AKDGGVFRVT DGLLDKYGPT RVMNTPLAEN
     SIIGTAVGMA LGGMHPFPEI QFGGFSYQAF SQIMHHAARF RTRTRSKMPI PMVIRFPASG
     GVGGPEIHSE SPEALFSHIG SLVVIEASTP YDAKGLLISA SHLNDPVVFI EPTKLYRMFK
     QEVPEDSYEV PIGKANVVNH GDDITIITYG TMSPVVQNAV KDKKVSADVI DLRTINPLDE
     KTILDSVKRT GRALIVHEDQ KSFSVGAEVS AVIAEKAMFE LKAPILRVAG FHTPIPFAGY
     ENYWIPNEKR VSQAIDSLLS A
//