ID A0A218NNE2_9ARCH Unreviewed; 357 AA.
AC A0A218NNE2;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE SubName: Full=2-oxoacid dehydrogenase multienzyme complex, 2-oxoacid decarboxylase (E1) component subunit alpha {ECO:0000313|EMBL:ASI13979.1};
GN ORFNames=Mia14_0676 {ECO:0000313|EMBL:ASI13979.1};
OS Candidatus Mancarchaeum acidiphilum.
OC Archaea; Candidatus Micrarchaeota; Candidatus Mancarchaeum.
OX NCBI_TaxID=1920749 {ECO:0000313|EMBL:ASI13979.1, ECO:0000313|Proteomes:UP000197679};
RN [1] {ECO:0000313|EMBL:ASI13979.1, ECO:0000313|Proteomes:UP000197679}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mia14 {ECO:0000313|EMBL:ASI13979.1,
RC ECO:0000313|Proteomes:UP000197679};
RX PubMed=28680072; DOI=10.1038/s41467-017-00104-7;
RA Golyshina O., Toshchakov S., Makarova K., Gavrilov S., Korzhenkov A.,
RA La Cono V., Arcadi E., Nechitaylo T., Ferrer M., Kublanov I., Wolf Y.,
RA Yakimov M., Golyshin P., Slesarev A., Kozyavkin S.;
RT "'ARMAN' archaea depend on association with euryarchaeal host in culture
RT and in situ.";
RL Nat. Commun. 8:60-60(2017).
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DR EMBL; CP019964; ASI13979.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A218NNE2; -.
DR KEGG; marh:Mia14_0676; -.
DR OrthoDB; 25266at2157; -.
DR Proteomes; UP000197679; Chromosome.
DR GO; GO:0016624; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; IEA:InterPro.
DR GO; GO:0006082; P:organic acid metabolic process; IEA:UniProt.
DR GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR GO; GO:0044272; P:sulfur compound biosynthetic process; IEA:UniProt.
DR CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR InterPro; IPR001017; DH_E1.
DR InterPro; IPR017596; PdhA/BkdA.
DR InterPro; IPR029061; THDP-binding.
DR NCBIfam; TIGR03181; PDH_E1_alph_x; 1.
DR PANTHER; PTHR43380; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43380:SF1; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR Pfam; PF00676; E1_dh; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000197679}.
FT DOMAIN 41..326
FT /note="Dehydrogenase E1 component"
FT /evidence="ECO:0000259|Pfam:PF00676"
SQ SEQUENCE 357 AA; 39750 MW; CB0CCE274BE0DE26 CRC64;
MIKEVFNGNI KNMQIMDEDG NIDNSLFPKD LEPKKIIELY KFMSLGRAVS NKLLTLQRLG
KVATFAPLNG EEAVQAGSAY AADASDFIVP TFRNHLPFIM RGVPLENLFI AVKGYEEAYS
SILQKRLTPE AIAVGSQYTQ AAGIAFSMKY QKYKNAVIVY GGDGSTSEGD FYEALNFAGV
FNLPIVFVIE NNEWAISVPR SSQTASKTLA QKAVAAGVDA IQVDGNDVIA VYKATKDALD
SVKKGGKPMV IEALTYRMGM HTTSDDPTKY RPESEVDGWK PKDPILRLRK YLVSNRLWND
SMDEDMQNQN KSLIDDATAK VNEAKANPKA MFDNVYSFMP ETLKEEEDEA LKNNFWQ
//
