ID A0A218P1V2_THECE Unreviewed; 411 AA.
AC A0A218P1V2;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=anthranilate synthase {ECO:0000256|ARBA:ARBA00012266};
DE EC=4.1.3.27 {ECO:0000256|ARBA:ARBA00012266};
GN ORFNames=A3L02_04675 {ECO:0000313|EMBL:ASI98903.1};
OS Thermococcus celer Vu 13 = JCM 8558.
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Thermococcus.
OX NCBI_TaxID=1293037 {ECO:0000313|EMBL:ASI98903.1, ECO:0000313|Proteomes:UP000197156};
RN [1] {ECO:0000313|EMBL:ASI98903.1, ECO:0000313|Proteomes:UP000197156}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Vu 13 {ECO:0000313|EMBL:ASI98903.1,
RC ECO:0000313|Proteomes:UP000197156};
RA Oger P.M.;
RT "Complete genome sequence of Thermococcus celer.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chorismate + L-glutamine = anthranilate + H(+) + L-glutamate +
CC pyruvate; Xref=Rhea:RHEA:21732, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16567, ChEBI:CHEBI:29748, ChEBI:CHEBI:29985,
CC ChEBI:CHEBI:58359; EC=4.1.3.27;
CC Evidence={ECO:0000256|ARBA:ARBA00000329};
CC -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC tryptophan from chorismate: step 1/5. {ECO:0000256|ARBA:ARBA00004873}.
CC -!- SIMILARITY: Belongs to the anthranilate synthase component I family.
CC {ECO:0000256|ARBA:ARBA00009562}.
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DR EMBL; CP014854; ASI98903.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A218P1V2; -.
DR KEGG; tce:A3L02_04675; -.
DR OrthoDB; 25514at2157; -.
DR UniPathway; UPA00035; UER00040.
DR Proteomes; UP000197156; Chromosome.
DR GO; GO:0004049; F:anthranilate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.60.120.10; Anthranilate synthase; 1.
DR InterPro; IPR005801; ADC_synthase.
DR InterPro; IPR019999; Anth_synth_I-like.
DR InterPro; IPR006805; Anth_synth_I_N.
DR InterPro; IPR015890; Chorismate_C.
DR PANTHER; PTHR11236; AMINOBENZOATE/ANTHRANILATE SYNTHASE; 1.
DR PANTHER; PTHR11236:SF9; ANTHRANILATE SYNTHASE COMPONENT 1; 1.
DR Pfam; PF04715; Anth_synt_I_N; 1.
DR Pfam; PF00425; Chorismate_bind; 1.
DR PRINTS; PR00095; ANTSNTHASEI.
DR SUPFAM; SSF56322; ADC synthase; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW Aromatic amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023141};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Tryptophan biosynthesis {ECO:0000256|ARBA:ARBA00022822}.
FT DOMAIN 7..119
FT /note="Anthranilate synthase component I N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04715"
FT DOMAIN 153..401
FT /note="Chorismate-utilising enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00425"
SQ SEQUENCE 411 AA; 46156 MW; BA8FFC60D41CA82D CRC64;
MQKHEYVSPV KLYAVIRDES YPFILESAEK SGRARYTYIS FNPLYTVKVG SRTEVDGSVV
SKISDPFDAL KEIHVKGLLV GYIAYDAAKN YIGKKPETPS VFGCYDSYFV YDHYLKKLFS
VNVDNADRLV ERAKRVEIEG GKGNSSIVKA GSKEKFMEMV EKGKEQIFEG EVYQIVLSRE
YVIETDLNPF QMYLNLREAN PSPYMFLLEF DRALIGSSPE TMGRVEGRNF IINPIAGTAK
REKGREAEIA DRLLNDEKER AEHVMLVDLA RNDVRKVSRS GSVRVSKFMD VISYPSVLHI
ESEVVGELRA GMTHFDAMKA AFPAGTVTGA PKLRAIELID EIERDNRGVY AGAVGYFSEN
LSDLAIAIRM IEFDGKARVR AGAGIVADSN PEKEFYETEN KIVRVLRAVG L
//
