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Database: UniProt
Entry: A0A218P796_9EURY
LinkDB: A0A218P796_9EURY
Original site: A0A218P796_9EURY 
ID   A0A218P796_9EURY        Unreviewed;       406 AA.
AC   A0A218P796;
DT   27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT   27-SEP-2017, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   RecName: Full=3-hexulose-6-phosphate synthase {ECO:0000256|ARBA:ARBA00012890};
DE            EC=4.1.2.43 {ECO:0000256|ARBA:ARBA00012890};
GN   ORFNames=A3L08_04625 {ECO:0000313|EMBL:ASJ06656.1};
OS   Thermococcus pacificus.
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Thermococcus.
OX   NCBI_TaxID=71998 {ECO:0000313|EMBL:ASJ06656.1, ECO:0000313|Proteomes:UP000197418};
RN   [1] {ECO:0000313|EMBL:ASJ06656.1, ECO:0000313|Proteomes:UP000197418}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=P-4 {ECO:0000313|EMBL:ASJ06656.1,
RC   ECO:0000313|Proteomes:UP000197418};
RA   Oger P.M.;
RT   "Complete genome sequence of Thermococcus pacificus type strain P4.";
RL   Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-ribulose 5-phosphate + formaldehyde = D-arabino-hex-3-ulose
CC         6-phosphate; Xref=Rhea:RHEA:25201, ChEBI:CHEBI:16842,
CC         ChEBI:CHEBI:58121, ChEBI:CHEBI:58542; EC=4.1.2.43;
CC         Evidence={ECO:0000256|ARBA:ARBA00000718};
CC   -!- PATHWAY: One-carbon metabolism; formaldehyde assimilation via RuMP
CC       pathway; D-fructose 6-phosphate from D-ribulose 5-phosphate and
CC       formaldehyde: step 1/2. {ECO:0000256|ARBA:ARBA00005014}.
CC   -!- SIMILARITY: Belongs to the HPS/KGPDC family. HPS subfamily.
CC       {ECO:0000256|ARBA:ARBA00006350}.
CC   -!- SIMILARITY: Belongs to the SIS family. PHI subfamily.
CC       {ECO:0000256|ARBA:ARBA00009235}.
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DR   EMBL; CP015102; ASJ06656.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A218P796; -.
DR   KEGG; tpaf:A3L08_04625; -.
DR   OrthoDB; 350569at2157; -.
DR   UniPathway; UPA00294; UER00434.
DR   Proteomes; UP000197418; Chromosome.
DR   GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR   GO; GO:0043801; F:hexulose-6-phosphate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016853; F:isomerase activity; IEA:InterPro.
DR   GO; GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:InterPro.
DR   GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR   GO; GO:1901135; P:carbohydrate derivative metabolic process; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   GO; GO:0019647; P:formaldehyde assimilation via ribulose monophosphate cycle; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd04726; KGPDC_HPS; 1.
DR   CDD; cd05005; SIS_PHI; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR017553; 3-hexulose-6-phosphate_synth.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR041710; HPS/KGPDC.
DR   InterPro; IPR001754; OMPdeCOase_dom.
DR   InterPro; IPR017552; PHI/rmpB.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   InterPro; IPR001347; SIS_dom.
DR   InterPro; IPR046348; SIS_dom_sf.
DR   NCBIfam; TIGR03128; RuMP_HxlA; 1.
DR   NCBIfam; TIGR03127; RuMP_HxlB; 1.
DR   PANTHER; PTHR43443; 3-HEXULOSE-6-PHOSPHATE ISOMERASE; 1.
DR   PANTHER; PTHR43443:SF1; 3-HEXULOSE-6-PHOSPHATE ISOMERASE; 1.
DR   Pfam; PF00215; OMPdecase; 1.
DR   Pfam; PF01380; SIS; 1.
DR   SMART; SM00934; OMPdecase; 1.
DR   SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 1.
DR   SUPFAM; SSF53697; SIS domain; 1.
DR   PROSITE; PS51464; SIS; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239};
KW   One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563}.
FT   DOMAIN          241..393
FT                   /note="SIS"
FT                   /evidence="ECO:0000259|PROSITE:PS51464"
SQ   SEQUENCE   406 AA;  44261 MW;  5612A9546154E3B2 CRC64;
     MILQVALDLT DIEQAISIAE KAARGGAHWL EVGTPLIKKE GMRAVELMKR RFPDRKIVAD
     LKTMDTGALE VEMAARHGAD VVSILGVADD KTIMDAVEVA RRYGIRVMVD LIGVKDKVKR
     AKELEKMGVH YILVHTGIDE QVQGKSPLED LEKVVKAVKV PVAVAGGLNL QTIPKVVELG
     ATIIIVGGAI TKAEDPEDVT RKIIDLFWGE YMMTIRKAMT DITEHINGVA ESLKLEQVRG
     FVDAMIGANK IFIYGAGRSG LVGKAFAMRL MHLDFNVYVV GETITPAFEQ GDLLIAISGS
     GETKSIVDAA QIARAQGGKV VAITSYANST LGKLADVVLE IPGRTKSDVP TDYIARQMLT
     KYKWIAPMGT LFEDSTMIFL DGVIALLMAT FQKTEKDMKR KHATLE
//
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