ID A0A218P796_9EURY Unreviewed; 406 AA.
AC A0A218P796;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=3-hexulose-6-phosphate synthase {ECO:0000256|ARBA:ARBA00012890};
DE EC=4.1.2.43 {ECO:0000256|ARBA:ARBA00012890};
GN ORFNames=A3L08_04625 {ECO:0000313|EMBL:ASJ06656.1};
OS Thermococcus pacificus.
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Thermococcus.
OX NCBI_TaxID=71998 {ECO:0000313|EMBL:ASJ06656.1, ECO:0000313|Proteomes:UP000197418};
RN [1] {ECO:0000313|EMBL:ASJ06656.1, ECO:0000313|Proteomes:UP000197418}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P-4 {ECO:0000313|EMBL:ASJ06656.1,
RC ECO:0000313|Proteomes:UP000197418};
RA Oger P.M.;
RT "Complete genome sequence of Thermococcus pacificus type strain P4.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-ribulose 5-phosphate + formaldehyde = D-arabino-hex-3-ulose
CC 6-phosphate; Xref=Rhea:RHEA:25201, ChEBI:CHEBI:16842,
CC ChEBI:CHEBI:58121, ChEBI:CHEBI:58542; EC=4.1.2.43;
CC Evidence={ECO:0000256|ARBA:ARBA00000718};
CC -!- PATHWAY: One-carbon metabolism; formaldehyde assimilation via RuMP
CC pathway; D-fructose 6-phosphate from D-ribulose 5-phosphate and
CC formaldehyde: step 1/2. {ECO:0000256|ARBA:ARBA00005014}.
CC -!- SIMILARITY: Belongs to the HPS/KGPDC family. HPS subfamily.
CC {ECO:0000256|ARBA:ARBA00006350}.
CC -!- SIMILARITY: Belongs to the SIS family. PHI subfamily.
CC {ECO:0000256|ARBA:ARBA00009235}.
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DR EMBL; CP015102; ASJ06656.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A218P796; -.
DR KEGG; tpaf:A3L08_04625; -.
DR OrthoDB; 350569at2157; -.
DR UniPathway; UPA00294; UER00434.
DR Proteomes; UP000197418; Chromosome.
DR GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR GO; GO:0043801; F:hexulose-6-phosphate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0016853; F:isomerase activity; IEA:InterPro.
DR GO; GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:InterPro.
DR GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR GO; GO:1901135; P:carbohydrate derivative metabolic process; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0019647; P:formaldehyde assimilation via ribulose monophosphate cycle; IEA:UniProtKB-UniPathway.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR CDD; cd04726; KGPDC_HPS; 1.
DR CDD; cd05005; SIS_PHI; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR017553; 3-hexulose-6-phosphate_synth.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR041710; HPS/KGPDC.
DR InterPro; IPR001754; OMPdeCOase_dom.
DR InterPro; IPR017552; PHI/rmpB.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR InterPro; IPR001347; SIS_dom.
DR InterPro; IPR046348; SIS_dom_sf.
DR NCBIfam; TIGR03128; RuMP_HxlA; 1.
DR NCBIfam; TIGR03127; RuMP_HxlB; 1.
DR PANTHER; PTHR43443; 3-HEXULOSE-6-PHOSPHATE ISOMERASE; 1.
DR PANTHER; PTHR43443:SF1; 3-HEXULOSE-6-PHOSPHATE ISOMERASE; 1.
DR Pfam; PF00215; OMPdecase; 1.
DR Pfam; PF01380; SIS; 1.
DR SMART; SM00934; OMPdecase; 1.
DR SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 1.
DR SUPFAM; SSF53697; SIS domain; 1.
DR PROSITE; PS51464; SIS; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563}.
FT DOMAIN 241..393
FT /note="SIS"
FT /evidence="ECO:0000259|PROSITE:PS51464"
SQ SEQUENCE 406 AA; 44261 MW; 5612A9546154E3B2 CRC64;
MILQVALDLT DIEQAISIAE KAARGGAHWL EVGTPLIKKE GMRAVELMKR RFPDRKIVAD
LKTMDTGALE VEMAARHGAD VVSILGVADD KTIMDAVEVA RRYGIRVMVD LIGVKDKVKR
AKELEKMGVH YILVHTGIDE QVQGKSPLED LEKVVKAVKV PVAVAGGLNL QTIPKVVELG
ATIIIVGGAI TKAEDPEDVT RKIIDLFWGE YMMTIRKAMT DITEHINGVA ESLKLEQVRG
FVDAMIGANK IFIYGAGRSG LVGKAFAMRL MHLDFNVYVV GETITPAFEQ GDLLIAISGS
GETKSIVDAA QIARAQGGKV VAITSYANST LGKLADVVLE IPGRTKSDVP TDYIARQMLT
KYKWIAPMGT LFEDSTMIFL DGVIALLMAT FQKTEKDMKR KHATLE
//