ID A0A218QVZ6_9CYAN Unreviewed; 279 AA.
AC A0A218QVZ6;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE SubName: Full=Aldo/keto reductase {ECO:0000313|EMBL:GAX45797.1};
GN ORFNames=NIES4075_68180 {ECO:0000313|EMBL:GAX45797.1};
OS Tolypothrix sp. NIES-4075.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Tolypothrichaceae;
OC Tolypothrix.
OX NCBI_TaxID=2005459 {ECO:0000313|EMBL:GAX45797.1, ECO:0000313|Proteomes:UP000198313};
RN [1] {ECO:0000313|EMBL:GAX45797.1, ECO:0000313|Proteomes:UP000198313}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIES-4075 {ECO:0000313|EMBL:GAX45797.1,
RC ECO:0000313|Proteomes:UP000198313};
RA Hirose Y., Shimura Y., Fujisawa T., Nakamura Y., Kawachi M.;
RT "Genome sequencing of cyanobaciteial culture collection at National
RT Institute for Environmental Studies (NIES).";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAX45797.1}.
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DR EMBL; BDUC01000020; GAX45797.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A218QVZ6; -.
DR OrthoDB; 9809990at2; -.
DR Proteomes; UP000198313; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR43638; OXIDOREDUCTASE, ALDO/KETO REDUCTASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR43638:SF3; OXIDOREDUCTASE, ALDO_KETO REDUCTASE FAMILY PROTEIN; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 1.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000198313}.
FT DOMAIN 16..265
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT ACT_SITE 52
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 108
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 75
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 279 AA; 30553 MW; A18BC4CB5723647A CRC64;
MEQHRFGSTQ REVAVIGQGT WYIDNGDRAS AIAALRQGLD LGMTHIDTAQ MYGSAEEVVA
EAIAGRRDQV FLVSKVLPGN ASRRGTIVAC EKSLARLHTD RLDSYLLHWR GQHPLEETIA
AFEQLQHEGK ILCWGVSNFD VPDLEAVQKI AGEGSVVCNQ VLYHLRERAI EHAVIPWCEK
HGVAVVAYSP FGHGDFPSSR TTAGRVLQEI AAAHNATPRQ VALRFLVRHS SLFAIPKASN
PEHAAENAGA GELNLTQTEL DRIDAAFPTG SRPRVLPML
//
