ID A0A218UA31_9PASE Unreviewed; 620 AA.
AC A0A218UA31;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Long-chain-fatty-acid--CoA ligase ACSBG1 {ECO:0000256|ARBA:ARBA00040478};
DE EC=6.2.1.3 {ECO:0000256|ARBA:ARBA00026121};
DE AltName: Full=Acyl-CoA synthetase bubblegum family member 1 {ECO:0000256|ARBA:ARBA00043191};
GN Name=ACSBG1 {ECO:0000313|EMBL:OWK50535.1};
GN ORFNames=RLOC_00005231 {ECO:0000313|EMBL:OWK50535.1};
OS Lonchura striata domestica (Bengalese finch).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Lonchura.
OX NCBI_TaxID=299123 {ECO:0000313|EMBL:OWK50535.1, ECO:0000313|Proteomes:UP000197619};
RN [1] {ECO:0000313|EMBL:OWK50535.1, ECO:0000313|Proteomes:UP000197619}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=White83orange57 {ECO:0000313|EMBL:OWK50535.1};
RA Colquitt B.M., Brainard M.S.;
RT "Genome of assembly of the Bengalese finch, Lonchura striata domestica.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP
CC + diphosphate; Xref=Rhea:RHEA:36139, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:61526,
CC ChEBI:CHEBI:72745, ChEBI:CHEBI:456215;
CC Evidence={ECO:0000256|ARBA:ARBA00036716};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + CoA + hexadecanoate = AMP + diphosphate + hexadecanoyl-
CC CoA; Xref=Rhea:RHEA:30751, ChEBI:CHEBI:7896, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379,
CC ChEBI:CHEBI:456215; Evidence={ECO:0000256|ARBA:ARBA00036355};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-
CC CoA + AMP + diphosphate; Xref=Rhea:RHEA:15421, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57560,
CC ChEBI:CHEBI:83139, ChEBI:CHEBI:456215; EC=6.2.1.3;
CC Evidence={ECO:0000256|ARBA:ARBA00036813};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00004541}. Endoplasmic
CC reticulum {ECO:0000256|ARBA:ARBA00004240}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}. Microsome
CC {ECO:0000256|ARBA:ARBA00004144}. Vesicle
CC {ECO:0000256|ARBA:ARBA00004373}.
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC Bubblegum subfamily. {ECO:0000256|ARBA:ARBA00038034}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWK50535.1}.
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DR EMBL; MUZQ01000530; OWK50535.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A218UA31; -.
DR STRING; 299123.ENSLSDP00000014233; -.
DR Proteomes; UP000197619; Unassembled WGS sequence.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43272:SF93; ACYL-COA SYNTHETASE BUBBLEGUM FAMILY MEMBER 1; 1.
DR PANTHER; PTHR43272; LONG-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022848};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:OWK50535.1};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Microsome {ECO:0000256|ARBA:ARBA00022848};
KW Reference proteome {ECO:0000313|Proteomes:UP000197619}.
FT DOMAIN 86..365
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 620 AA; 69105 MW; A3B1F424B47953F9 CRC64;
MPNSGKTLTK QLQTENARNV SGSCENGAFT DAQTVGRNLL PHLEETRGEG IEPADSLWTS
FADGRVRLRI DNSCPQTPIT VHQMFKESLE KYGSLNALAS KKNGKWEKIT FSEYYCLSRK
AAKSFLKLGL ERFHSVAILG FNSPEWFISA VGAIFAGGIV TGIYATNSPE ACHYIAHDSK
TDIMVVENQK QLDKIMQIWN RLPHLKAVVL YKDSIAERHP NLYMMEEFLE LGDDISDSTL
DDIINSQKPN QCCVLIYTSG TTGKPKGAML SHDNITWTSA HCSRAGGMQP AEVQQESIVS
YLPLSHIAAQ IYDLWTGIKW GEQVYFAEPD ALKGSLINTL KEVQPTSHMG VPRVWEKIME
KLKDASAQSG FMKKKMLSWA MSLSLEKNLH GSNSCGKPVP GCRVKLVDKD TEGNGEICFW
GRTVFMGYLN MEDRTKESFD EEGWLHSGDL GKLDNDGFLY VTGRIKDLII TAGGENVPPI
PIEDAVKKEL PIVSNAMVIG DKKKFLSMFL TLKSVLDPDT SDPTDILTEQ ARDFCQRSGS
KATKVSDIVA TRDQATYRAI QEGIDRVNST ATNRVHCIQK WIVLPRDFSI SGGELGPTMK
LKRLAVLEKY RNEVDSFYKE
//
