ID A0A218UK78_9PASE Unreviewed; 1895 AA.
AC A0A218UK78;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Plexin-A2 {ECO:0000313|EMBL:OWK53782.1};
GN Name=PLXNA2 {ECO:0000313|EMBL:OWK53782.1};
GN ORFNames=RLOC_00010053 {ECO:0000313|EMBL:OWK53782.1};
OS Lonchura striata domestica (Bengalese finch).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Lonchura.
OX NCBI_TaxID=299123 {ECO:0000313|EMBL:OWK53782.1, ECO:0000313|Proteomes:UP000197619};
RN [1] {ECO:0000313|EMBL:OWK53782.1, ECO:0000313|Proteomes:UP000197619}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=White83orange57 {ECO:0000313|EMBL:OWK53782.1};
RA Colquitt B.M., Brainard M.S.;
RT "Genome of assembly of the Bengalese finch, Lonchura striata domestica.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC -!- SIMILARITY: Belongs to the plexin family.
CC {ECO:0000256|ARBA:ARBA00010297}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWK53782.1}.
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DR EMBL; MUZQ01000265; OWK53782.1; -; Genomic_DNA.
DR STRING; 299123.ENSLSDP00000010907; -.
DR OrthoDB; 1387371at2759; -.
DR Proteomes; UP000197619; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR CDD; cd00603; IPT_PCSR; 1.
DR CDD; cd01180; IPT_plexin_repeat1; 1.
DR CDD; cd01179; IPT_plexin_repeat2; 1.
DR CDD; cd01181; IPT_plexin_repeat3; 1.
DR CDD; cd12790; RasGAP_plexin_A; 1.
DR CDD; cd11272; Sema_plexin_A2; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 6.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR042826; Plexin-A2_sema.
DR InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR InterPro; IPR046800; Plexin_RBD.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR041019; TIG1_plexin.
DR InterPro; IPR041362; TIG2_plexin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR PANTHER; PTHR22625:SF37; PLEXIN-A2; 1.
DR Pfam; PF08337; Plexin_cytopl; 1.
DR Pfam; PF20170; Plexin_RBD; 1.
DR Pfam; PF01437; PSI; 3.
DR Pfam; PF01403; Sema; 1.
DR Pfam; PF01833; TIG; 4.
DR Pfam; PF18020; TIG_2; 1.
DR Pfam; PF17960; TIG_plexin; 1.
DR SMART; SM00429; IPT; 4.
DR SMART; SM00423; PSI; 3.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF81296; E set domains; 4.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF103575; Plexin repeat; 2.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000197619};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..34
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 35..1895
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012690953"
FT TRANSMEM 1237..1261
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 20..508
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT COILED 1265..1292
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1895 AA; 210766 MW; E7F3045E259A36CE CRC64;
MDQRRNWPRG QNSDGWSVAL LCLFLASLSR NVSSNALFNT FHSEHRDWTF NHLAVHRGTG
AVYVGAINRV YKLSGNLTIL VAHKTGPEED NKSCYPPLIV QPCGEVLTLT NNVNKLLIID
YSENRLLACG SLYQGVCKLL RLDDLFILVE PSHKKEHYLS SVNKTGTMYG VIVRSEGEDG
KLFIGTAVDG KQDYFPTLSS RKLPRDPESS AMLDYELHSD FVSSLIKIPS DTLALVSHFD
IFYIYGFASG NFVYFLTVQP ETPEGVSINS ASDLFYTSRI VRLCKDDPKF HSYVSLPFGC
VRGDTEYRLL QAAYLSKPGE VLARALNITA QEDVLFAIFS KGQKQYHHPP DDSALCAFPI
RTVNAHIKER LRSCYQGEGN LELNWLLGKD VQCTKAPVPI DDNFCGLDIN QPLGGSVPVD
GVPLFTSSRD RMTSVASYVY NGYSVVFVGT KTGRLKKIRA DGPPQGGIQY EVVPVFKDGS
PVLRDMAFST DHKFLYVMSE RQVSRVPVES CEQYTTCQEC LSSGDPHCGW CSLHHMCSPR
DRCERAEEPF RFAGSIGQCL SVAVQPSSIS VSEHSLLLSL RVSDAPDLSA GVSCLFGNLS
EVEGQVSGSQ VLCVSPAAKD VPAIPEDQDW FGVVLQLRSR ETGRTFVSTE FKFYNCSAHQ
LCLSCVNSAF RCHWCKYRNL CTHDPTTCSF QEGRINVSED CPQLFPTEEI LIPVGEVKPI
TLKARNLPQP QSGQRGYECV LSIQGIVHRV PALRFNSSSV QCQNSSYLYD GMDISNLAVD
FAVVWNGNFV IDNPENLKVH LYKCAAQRES CGLCLKADPK FECGWCSGEA RCTLRPHCGS
PGAQPWLDWS SHNVKCSNPR ITEILTVSGP PEGGTRVTIR GVNLGLDFSE IARGVQVAGV
QCTPLPEHYV VAEQIVCEMG QALPGISSGP VLLCIGECQP EFTAKSAQHY MFVTPAVSFL
SPSRGPESGG TMVTISGHHL GAGSRVSVLL GNQTCEFHAR SMNEIVCVSA PSAHGLGAVQ
VSVSVDRAQL ERTLLFEYID DPKVQHIEPE WSIASGHTPL TVTGSNLDVI QEPRIRVKYN
GKEFVNVCRV VNATALACLA PPLSAEYRPG LDAVERPDEL GFIFNNVQSL LVYNDTKFIY
YPNPTFEMLS SSGVLEQKPG SPIILKGRNL CPPAPGGAKL NYTVLIGETP CAVTVSETQL
LCEPPTLTGQ HRVTVRVGGV TFSPGSVSIV SDSLLTLPAI VSIAAGGSLL LIIVIIVLIA
YKRKSRENDL TLKRLQMQMD NLESRVALEC KEAFAELQTD INELTSDLDR SGIPYLDYRT
YAMRVLFPGI EDHPVLRELE VQGNGQQSVE KALKLFAQLL NNKVFLLTFI RTLELQRSFS
MRDRGNVASL IMTGLQGKLE YATDVLKQLL SDLIEKNLEN KNHPKLLLRR TESVAEKMLT
NWFAFLLHRF LKECAGEPLF MLYCAIKQQM EKGPIDAITG EARYSLSEDK LIRQQIEYKT
LILNCVNPDN ENSPEIPVKV LNCDTITQVK EKILDAVYKN VPYSQRPRAV DMDLEWRQGR
IARVVLQDED ITTKIEGDWK RLNTLVHYQV SDRSVVALVP KQTSSYNIPA SASISRTSIS
RYDSTFRYTG SPDSLRSRAP MITPDLESGV KVWHLVKNHD HGDQKEGDRG SKMVSEIYLT
RLLATKGTLQ KFVDDLFETL FSTVHRGSAL PLAIKYMFDF LDEQADKHGI HDTDVRHTWK
SNCLPLRFWV NVIKNPQFVF DIHKGSITDA CLSVVAQTFM DSCSTSEHRL GKDSPSNKLL
YAKDIPSYKS WVERYYADIA KLPAISDQDM NAYLAEQSRL HAVEFNMLSA LNEIYSYVSK
YSEELIGALE QDEQARRQRL AYKVEQLIGA MSFES
//
