ID A0A218ULD8_9PASE Unreviewed; 2230 AA.
AC A0A218ULD8;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Unconventional myosin-VIIa {ECO:0000313|EMBL:OWK54565.1};
GN Name=MYO7A {ECO:0000313|EMBL:OWK54565.1};
GN ORFNames=RLOC_00000838 {ECO:0000313|EMBL:OWK54565.1};
OS Lonchura striata domestica (Bengalese finch).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Lonchura.
OX NCBI_TaxID=299123 {ECO:0000313|EMBL:OWK54565.1, ECO:0000313|Proteomes:UP000197619};
RN [1] {ECO:0000313|EMBL:OWK54565.1, ECO:0000313|Proteomes:UP000197619}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=White83orange57 {ECO:0000313|EMBL:OWK54565.1};
RA Colquitt B.M., Brainard M.S.;
RT "Genome of assembly of the Bengalese finch, Lonchura striata domestica.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|PROSITE-ProRule:PRU00782}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWK54565.1}.
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DR EMBL; MUZQ01000236; OWK54565.1; -; Genomic_DNA.
DR STRING; 299123.ENSLSDP00000003144; -.
DR Proteomes; UP000197619; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0120025; C:plasma membrane bounded cell projection; IEA:UniProt.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd17092; FERM1_F1_Myosin-VII; 1.
DR CDD; cd17093; FERM2_F1_Myosin-VII; 1.
DR CDD; cd14473; FERM_B-lobe; 2.
DR CDD; cd13198; FERM_C1_MyoVII; 1.
DR CDD; cd13199; FERM_C2_MyoVII; 1.
DR CDD; cd01381; MYSc_Myo7; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 2.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 1.20.80.10; -; 2.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 3.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR041793; MyoVII_FERM_C1.
DR InterPro; IPR041794; MyoVII_FERM_C2.
DR InterPro; IPR036106; MYSc_Myo7.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR22692; MYOSIN VII, XV; 1.
DR PANTHER; PTHR22692:SF34; MYOSIN VIIA; 1.
DR Pfam; PF00373; FERM_M; 2.
DR Pfam; PF00612; IQ; 4.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF00784; MyTH4; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00295; B41; 2.
DR SMART; SM00015; IQ; 4.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00139; MyTH4; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 2.
DR PROSITE; PS50057; FERM_3; 2.
DR PROSITE; PS50096; IQ; 4.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51016; MYTH4; 2.
DR PROSITE; PS01179; PID; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Coiled coil {ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000197619};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 109..791
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 1067..1273
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1278..1587
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 1709..1879
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1885..2220
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 2146..2173
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT REGION 668..690
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT COILED 917..985
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 208..215
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 2230 AA; 257329 MW; 05A59BB87E3F4B0B CRC64;
MVILRQMLKK KKVVFMQPCP EVVEDQERDQ GRWTLLRNVN QVLKPTTMLA GDYVWMDLKT
GREFDVPIGA VVKLCDSGQI QVVDDEGNEH WISPQNASHI KPMHPTSIHG VEDMIRLGDL
NEAGILRNLL IRYREHLIYT NCGGRTYTGS ILVAVNPYQL LPIYSPEQIR LYTNKKIGEM
PPHIFAIADN CYFNMQRNNK DQCCIISGES GAGKTESTKL ILQFLAAISG QHSWIEQQVL
EANPILEAFG NAKTIRNDNS SRFGKYIDIH FNKRGAIEGA KIEQYLLEKS RVCRQAQDER
NYHVFYCMLR GMTVEQKKKL GLGKATDYNY LAMGNCTTCD GRDDSKEYAN IRSAMKVLMF
TDTENWEISK LLAAILHMGN LQYEARTYDN LDACEVVQSA SLITAATLLE VEPQDVMNCL
TSRTIITRGE TVSTPLSMEQ ALDVRDAFVK GIYGRLFVWI VEKINAAIYR PPSQELKSIR
RSIGLLDIFG FENFTVNSFE QLCINFANEN LQQFFVRHVF KLEQEEYNLE NINWQHIEFT
DNQDALDMIA IKPMNIISLI DEESKFPKGT DATMLHKLNS QHKLNTNYIP PKNNYETQFG
INHFAGIVYY ETKGFLEKNR DTLHGDIIQL VHSSKNKFIK QIFQADVAMG AETRKRSPTL
SSQFKRSLEL LMRTLSVCQP FFVRCIKPNE YKKPMLFDRE LCVRQLRYSG MMETIRIRRA
GYPIRYTFVE FVDRYRVLMP GVKPAYKQGD LRGTCQRIAE AVLGKDDDWQ IGKTKIFLKD
HHDMLLEIER DKAITDKVIL IQKVVRGYKD RSNFLKVRNS VLMIQRYWRG HNCRKNYGAM
RIGFLRLQAL YRSRKLHKQY HMARRRIIEF QARCRGYLVR RAFRHRLWAV LTIQAYARGM
IARRLYKRLR GEYYRRLEAE KLRLAEEERL RKEMSAKKAK EEAEKKHQVR LAQLAREDAE
REVKEKEEAR RKKELLEKME RARNEPVNDS EMVDKMFGFL GTTSSLPGQE GQAPNGFEDL
EQVQKELEEE DLDAALPLPE EEEEDLSEYK FAKFAATYFQ GTTTHTYIRR PLKQPLLYHE
DEGDQLAALA VWITILRFMG DLPEPKYHTA MSDGGEKIPV MTKIYETLGK KTYKKELQAL
QGEGESTHVD GHKKNSVRHK LVSLTLKKKS KLTEEVTKRL HDGESTLQGN SMLEDRPTSN
LEKLHFIIGN GILRPALSQR SIQCVPCYQQ YLRNFINGGP PGYAPYCEER LRRTFANGTR
TQPPSWLELQ ATKSKKPIML PVTFMDGTTK TLLTDSATTA KELCNSLADK ISLKDRFGFS
LYIALFDKVS SLGSGNDHVM DAVSQCEQYA KEQGAQERNA PWRLFFRKEI FTPWHNPSED
NVATNLIYQQ IVRGVKFGEY RCDKEEDLAE LASQQYYVDY GSEMVLERLL NLIPSYIPDR
EITASKTVEK WAQFIIAAHK KGIYTQKRAD PKKVKEEVVD FARFKWPLLF SRFYEAFKFS
GPSLPKNDVI VAVNWTGVYF VDEQEQVLLE LSFPEITAVS SSRGGKLQGQ SFTLATIKGD
EYTFTSNNAE DIRDLVVTFL EGLRKRSNFL KGDLIVLDQD TGEQVMNSGW ANGFNERTKQ
RGDFPTDSVY VLPTVTMPPL EIVALVTMTP DQRQDVIRTS QMAVSDSEER VKPYTLEEFS
YDYFRPPPKH TLSRVMITKS RGKDKLWCYT REPIKQPLLK KILGSEELSQ EACMAFIDIL
ALLGSPLGLE LILDSYLPPV LKYMGDYPSK RTRSVNELTD QIFEGALKAE PLKDEIYCQT
LKQLTDNHIK YSEEKGWELL WLCTGLFPPS NILLPHVQRF LQSRKHHPLA ADCIQRLQKA
LRNGSRKYPP HLVEVEAIQH KTTQIFHKVY FPDDTDEAFE VESSTKAKDF CQNISNRLLL
KSSEGFSLFV KISDKVISVP EGDFFFDFVR HLTDWIKKAR PAKDGIVPSL TYQVFFMKKL
WTNTMPGKDS MADSIFHYYQ VRWDSSIAVG TWEGLRDHRH PLYLSVVLSS MQELPKYLRG
YHKCSREEVL QLAALIYRVK FEDDKSYFPS IPKLLKELVP QDLIRQLSPD DWKRSIMAYY
NKHAGKTREE AKLAFLKIIF KWPTFGSAFF EVKQTTEPNY PEILLIAINK HGVSLIDPKT
KDILITHPFT KISNWSSGNT YFHITIGNLV RGSKLLCETS LGYKMDDLLT SYISQMLTAM
SKQRSAKGSK
//
