ID A0A218ULP9_9PASE Unreviewed; 576 AA.
AC A0A218ULP9;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=Gap junction protein {ECO:0000256|RuleBase:RU000630};
GN Name=GJB1 {ECO:0000313|EMBL:OWK54340.1};
GN ORFNames=RLOC_00004942 {ECO:0000313|EMBL:OWK54340.1};
OS Lonchura striata domestica (Bengalese finch).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Lonchura.
OX NCBI_TaxID=299123 {ECO:0000313|EMBL:OWK54340.1, ECO:0000313|Proteomes:UP000197619};
RN [1] {ECO:0000313|EMBL:OWK54340.1, ECO:0000313|Proteomes:UP000197619}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=White83orange57 {ECO:0000313|EMBL:OWK54340.1};
RA Colquitt B.M., Brainard M.S.;
RT "Genome of assembly of the Bengalese finch, Lonchura striata domestica.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: One gap junction consists of a cluster of closely packed
CC pairs of transmembrane channels, the connexons, through which materials
CC of low MW diffuse from one cell to a neighboring cell.
CC {ECO:0000256|ARBA:ARBA00003922, ECO:0000256|RuleBase:RU000630}.
CC -!- SUBUNIT: A connexon is composed of a hexamer of connexins.
CC {ECO:0000256|RuleBase:RU000630}.
CC -!- SUBCELLULAR LOCATION: Cell junction, gap junction
CC {ECO:0000256|ARBA:ARBA00004610}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU000630}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU000630}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the connexin family. Beta-type (group I)
CC subfamily. {ECO:0000256|ARBA:ARBA00007858}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWK54340.1}.
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DR EMBL; MUZQ01000241; OWK54340.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A218ULP9; -.
DR STRING; 299123.ENSLSDP00000010032; -.
DR Proteomes; UP000197619; Unassembled WGS sequence.
DR GO; GO:0005922; C:connexin complex; IEA:InterPro.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR Gene3D; 1.20.1440.80; Gap junction channel protein cysteine-rich domain; 2.
DR InterPro; IPR000500; Connexin.
DR InterPro; IPR002267; Connexin32.
DR InterPro; IPR019570; Connexin_CCC.
DR InterPro; IPR017990; Connexin_CS.
DR InterPro; IPR013092; Connexin_N.
DR InterPro; IPR038359; Connexin_N_sf.
DR PANTHER; PTHR11984; CONNEXIN; 1.
DR PANTHER; PTHR11984:SF20; GAP JUNCTION BETA-1 PROTEIN; 1.
DR Pfam; PF00029; Connexin; 2.
DR PRINTS; PR00206; CONNEXIN.
DR PRINTS; PR01138; CONNEXINB1.
DR SMART; SM00037; CNX; 2.
DR SMART; SM01089; Connexin_CCC; 2.
DR PROSITE; PS00407; CONNEXINS_1; 2.
DR PROSITE; PS00408; CONNEXINS_2; 2.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Gap junction {ECO:0000256|ARBA:ARBA00022868,
KW ECO:0000256|RuleBase:RU000630};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000197619};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000630};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..40
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 131..157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 189..214
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 302..319
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 356..378
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 478..496
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 42..75
FT /note="Connexin N-terminal"
FT /evidence="ECO:0000259|SMART:SM00037"
FT DOMAIN 145..212
FT /note="Gap junction protein cysteine-rich"
FT /evidence="ECO:0000259|SMART:SM01089"
FT DOMAIN 321..354
FT /note="Connexin N-terminal"
FT /evidence="ECO:0000259|SMART:SM00037"
FT DOMAIN 435..501
FT /note="Gap junction protein cysteine-rich"
FT /evidence="ECO:0000259|SMART:SM01089"
FT REGION 390..410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 390..406
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 576 AA; 64482 MW; AC336D368D2857E3 CRC64;
MNWAGLYTVL SGVNRHSTAI GRIWLSVIFI FRIMVLVVAA ESVWGDEKSA FTCNTQQPGC
NSVCYDHFFP ISHIRLWALQ LILVTTPALL VAMHVAYQQH QEKKLLVLTG HADAKHMEEV
KKHKMRIAGS LWWTYVCSVV FRLLFEAVFM YIFYMLYPGY QMMRLVKCEA YPCPNTVDCF
ISRPTEKTIF TVFMLVTSSI CIILNMAELV YLVVRACARR SQHHTNPSSG KGSFYGHKHS
SEYKQNEINQ LLTEQDGSLK DMLRRNSGLQ EKGHHSKGMG DWSLLGRLLE NAQEHSTVVG
KVWLTVLFVF RILVLGAAAE RVWGDELSGF SCDTQQPGCQ NACYDSTFPI SHLRFWVLQI
IFVSTPSLVY LGHILHLVHL EEKAQQQKAA RASSGARRQR PRQPQLPAGN TRARVCMQGA
ILRTYICNIV FKALLEVGFI VGQYTLYGFQ LKPLYTCSRW PCPNTVNCYI SRPTEKTIFI
LFMMGVACVS LLLNLVEIYH LGLTKCRQGP GPKSRILTAP GGPVGPGSTY VTLPRGGSPL
AAGRPPHGLA QLKKAGAWLG VVGGSHRDVR TADLSV
//