ID   A0A218UMA6_9PASE        Unreviewed;       849 AA.
AC   A0A218UMA6;
DT   27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT   27-SEP-2017, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=ATP6V0A2 {ECO:0000313|EMBL:OWK54874.1};
GN   ORFNames=RLOC_00005736 {ECO:0000313|EMBL:OWK54874.1};
OS   Lonchura striata domestica (Bengalese finch).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC   Estrildinae; Lonchura.
OX   NCBI_TaxID=299123 {ECO:0000313|EMBL:OWK54874.1, ECO:0000313|Proteomes:UP000197619};
RN   [1] {ECO:0000313|EMBL:OWK54874.1, ECO:0000313|Proteomes:UP000197619}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=White83orange57 {ECO:0000313|EMBL:OWK54874.1};
RA   Colquitt B.M., Brainard M.S.;
RT   "Genome of assembly of the Bengalese finch, Lonchura striata domestica.";
RL   Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC       multimeric enzyme that catalyzes the translocation of protons across
CC       the membranes. Required for assembly and activity of the V-ATPase.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OWK54874.1}.
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DR   EMBL; MUZQ01000225; OWK54874.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A218UMA6; -.
DR   STRING; 299123.ENSLSDP00000007230; -.
DR   OrthoDB; 1967517at2759; -.
DR   Proteomes; UP000197619; Unassembled WGS sequence.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629:SF22; V-TYPE PROTON ATPASE 116 KDA SUBUNIT A 2; 1.
DR   PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW   ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000197619};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM        410..434
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        455..473
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        548..566
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        578..601
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        645..667
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        779..802
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   COILED          94..128
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   849 AA;  97181 MW;  E91F6EB60BBB1294 CRC64;
     MGALFRGEPV CLAQLFLQSG SAYECLSEVG ERGLAEFRDL NPNVSVFQRK YVNEVKKCEE
     MERILGYLVQ EIKKADIPLP EGDVAPPAPL LKHILEIQEQ LQKLETELRE VNLNKEKLRK
     NLLELTEYKY MLQITQNFVR RSPEHESHLH GNFEEFSSVE NEPLVDYNRT HRLSASLGFI
     SGLVHIAKIE AFEKMLWRVC KGYPFLTYAE LDKALEDPDT GKTTKWAVFL VSYWGEQIGQ
     KVKKICDCYR CHVYPYPDTT EERQAVVEGL NVRIQDLETV LNKTEEYLHQ VLYKASESIY
     TWVIQVKKMK AIYHVLNLCS FDVTNKCLIA EVWCPVADLQ NLRHALEEGS RKSGATIPSF
     MNTIPTTQPP PTLIRTNKFT SGFQNIVDAY GVGSYGEVNP ALYTIITFPF LFAVMFGDFG
     HGLLMFIFAL LAILNENHPR LKRAQDETMK MLFEGRYMIL LMGLFSIYTG LIYNDCFSKS
     INIFGSGWNV SAMYEKVWSD KDVESNQYLA LDPNVSGVYN GAYPFGIDPI WNLASNRLTF
     LNSFKMKMSV ILGVTHMTFG VVLGLFNHLH FKKTYNIYLV FIPELLFMLC IFGYLVFMIF
     FKWLAYSAEN STAAPSILIQ FINMFLFPSG ETQSFFNGQV PLQKFLLSVA FLCVPVMLLG
     KPLYLYWLHS GGRGIRMYRS GYKLIRKESE EELCLLSCPD LEEGVSHSDS GHREEDAEEL
     NFADVFMNQA IHTIEYCLGC ISNTASYLRL WALSLAHAQL SEVLWQMVMR VGLRVDTKYG
     VVLLIPVVAF FAVLTVFILL VMEGLSAFLH ALRLHWVEFQ NKFYSGGGYK FTPFSFKHIS
     LHFNKDGAL
//