ID A0A218US26_9PASE Unreviewed; 1277 AA.
AC A0A218US26;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 {ECO:0000313|EMBL:OWK56132.1};
GN Name=MAGI2 {ECO:0000313|EMBL:OWK56132.1};
GN ORFNames=RLOC_00002377 {ECO:0000313|EMBL:OWK56132.1};
OS Lonchura striata domestica (Bengalese finch).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Lonchura.
OX NCBI_TaxID=299123 {ECO:0000313|EMBL:OWK56132.1, ECO:0000313|Proteomes:UP000197619};
RN [1] {ECO:0000313|EMBL:OWK56132.1, ECO:0000313|Proteomes:UP000197619}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=White83orange57 {ECO:0000313|EMBL:OWK56132.1};
RA Colquitt B.M., Brainard M.S.;
RT "Genome of assembly of the Bengalese finch, Lonchura striata domestica.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWK56132.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; MUZQ01000172; OWK56132.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A218US26; -.
DR STRING; 299123.ENSLSDP00000023777; -.
DR Proteomes; UP000197619; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00992; PDZ_signaling; 6.
DR CDD; cd00201; WW; 2.
DR Gene3D; 2.20.70.10; -; 2.
DR Gene3D; 2.30.42.10; -; 6.
DR Gene3D; 3.30.63.10; Guanylate Kinase phosphate binding domain; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR10316; MEMBRANE ASSOCIATED GUANYLATE KINASE-RELATED; 1.
DR PANTHER; PTHR10316:SF27; MEMBRANE-ASSOCIATED GUANYLATE KINASE, WW AND PDZ DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF16663; MAGI_u1; 1.
DR Pfam; PF00595; PDZ; 6.
DR Pfam; PF00397; WW; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 6.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 6.
DR SUPFAM; SSF51045; WW domain; 2.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 6.
DR PROSITE; PS01159; WW_DOMAIN_1; 2.
DR PROSITE; PS50020; WW_DOMAIN_2; 2.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:OWK56132.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000197619};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000313|EMBL:OWK56132.1}.
FT DOMAIN 17..101
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 109..185
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT DOMAIN 303..336
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 349..382
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 427..496
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 605..668
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 764..846
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 906..996
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1141..1223
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 203..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 557..578
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 721..741
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 849..899
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 997..1099
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 282..302
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 860..899
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 997..1035
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1056..1072
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1277 AA; 141493 MW; 72FF5E294CCD7F95 CRC64;
MSKGLKKKSH WTSRVHEIVI VRNPEGQLGF ELKGGAENGQ FPYLGEVKPG KVAYEGGSKL
VPEELLLEVN ETPVAGLTIR DVLAVIKHCK DPIRLKCVKQ GGIVDKDLRH YLNLRFQKGS
VDHELQQIIR DNLYLRTVPC TTRPHKEGEV PGVDYIFITV EDFMELEKSG ALLESGTYED
NYYGTPKPPA EPAPLLLNVT DQILPGATPG AEGKRKRNKS VSNMEKTGIE PPEEEEEERP
VVNGNDVTVT PESSEHEEKS TAVSGEASTT QPCPAPGYGQ PEEAKEDMDV TKQTKPEEND
DLGPLPDNWE MAYTEKGEVY FIDHNTKTTS WLDPRLAKKA KPPEECKENE LPYGWEKIDD
PIYGTYYVDH INRRTQFENP VLEAKRKLQQ HNMPNAELGT KPMQAQGFRE KPLFTRDASQ
LKGTFLSTTL KKSNMGFGFT IIGGDEPDEF LQVKSVIPDG PAAQDGKMET GDVIVYINEV
CVLGHTHADV VKLFQSVPIG QSVNLVLCRG YPLPFDPEDP ANSMVPPLAV MERPPVVVNG
RHNYETYLEY ISRTSQSVPD VTDRPPHSLH SIPADSQLDS TFPPPAHDDN VSMASSGATQ
AELMTLTIVK GAQGFGFTIA DSPTGQRVKQ ILDIQGCPGL CEGDLIVEIN QQNVQNLSHA
EVVDILKECP VGSETSLIIH RGGFFSPWKT PKPMMERWEN QGSPQTSVSA PAMPQNIPYP
PTLHRSSFPD STEAFDPRKP DPYELYEKSR AIYESRRPDY KELDVHLRRM ESGFGFRILG
GDEPGQPILI GAVIAMGSAD RDGRLHPGDE LVYVDGIPVA GKTHRYVIDL MHNAARNGQV
NLTVRRKVLP TGEPCPENGR SPGSVSTHHS SPRSDYTTYA NSNHAASGSS ATPPEGFASH
SLQTSDVVIH RKENEGFGFV IISSLNRPDS GSTITVPHKI GRIIDGSPAD RCAKLKVGDR
ILAVNGQSII NMPHADIVKL IKDAGLSVTL RIIPQEELNS PASAPGSEKQ SPMAQQHSPM
AQQSPLAQQS PVAQHSPVAQ PPPPQPLQPQ GHENSYRSEV KARQDVKPDI RQPPFTDYRQ
SSTDYRQPPL DYRHPPVMDY QQPPPLDYRQ PPLMDYRQHS PDTRQFPLSE YRQPQDFDYF
TVDLEKGAKG FGFSIRGGRE YKMDLYVLRL AEDGPAVRNG RMRVGDQIIE INGESTRDMT
HARAIELIKS GGRRVRLLLK RGTGQVPEYG MVPSSLSMCM KSDKHGSPYF YLLGHPKDTT
NQTPGVLPLP PPQVCRK
//
