ID A0A218UUW5_9PASE Unreviewed; 736 AA.
AC A0A218UUW5;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Epidermal growth factor receptor kinase substrate 8-like protein 2 {ECO:0000313|EMBL:OWK57499.1};
GN Name=EPS8L2 {ECO:0000313|EMBL:OWK57499.1};
GN ORFNames=RLOC_00010175 {ECO:0000313|EMBL:OWK57499.1};
OS Lonchura striata domestica (Bengalese finch).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Lonchura.
OX NCBI_TaxID=299123 {ECO:0000313|EMBL:OWK57499.1, ECO:0000313|Proteomes:UP000197619};
RN [1] {ECO:0000313|EMBL:OWK57499.1, ECO:0000313|Proteomes:UP000197619}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=White83orange57 {ECO:0000313|EMBL:OWK57499.1};
RA Colquitt B.M., Brainard M.S.;
RT "Genome of assembly of the Bengalese finch, Lonchura striata domestica.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the EPS8 family.
CC {ECO:0000256|ARBA:ARBA00006197}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWK57499.1}.
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DR EMBL; MUZQ01000123; OWK57499.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A218UUW5; -.
DR STRING; 299123.ENSLSDP00000005632; -.
DR Proteomes; UP000197619; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd01210; PTB_EPS8; 1.
DR CDD; cd09540; SAM_EPS8-like; 1.
DR CDD; cd11764; SH3_Eps8; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR039801; EPS8-like.
DR InterPro; IPR033928; EPS8_PTB.
DR InterPro; IPR035462; Eps8_SH3.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR013625; PTB.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR041418; SAM_3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR12287:SF20; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE 8-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR12287; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8-RELATED PROTEIN; 1.
DR Pfam; PF08416; PTB; 1.
DR Pfam; PF18016; SAM_3; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00462; PTB; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS01179; PID; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000313|EMBL:OWK57499.1};
KW Receptor {ECO:0000313|EMBL:OWK57499.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000197619};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Transferase {ECO:0000313|EMBL:OWK57499.1}.
FT DOMAIN 51..171
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT DOMAIN 496..555
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 188..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 716..736
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..248
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 736 AA; 83994 MW; 2E4B2E4B57D6CC2D CRC64;
MNHKGSLNSN PGATNGSMGK AEGASKLSAK DLYEQRKKYS NSNIIMHETS QYHVQHLATF
IMDKSESITT VDDAIRKLIL LNSKEKIWTQ EMLLQVNDKS IRLLDCETQE ELEDFPLPTV
QHCQTVLNQM RYSSILLLVC QDSEQHKPDI HFFNCDEVEA EMVHEDIESA LADHKHGKKI
RPQTLKANQE KIKQRQSILP PPQGPAPIPI QHDMRSSAMN RNRVAPPSQH DTDYERRSSG
SHDHEESRAM LAQKIEKETQ ILNCTLDDIE VFVARLQKAA EAFRQLNQRK KGKKNKKKGP
AEGMLTLRAR PPSEAEFIDC FQKTKLAFNL LAKLRKHIQN PSASELVHFL FGPLELIVNS
CGGPELARSV LSPLLSKDAT DFLRGHLTPK EINLWDSLGE TWTRSRAEWP RDANIPTYIP
KFRNGWEPPT EIFRGAPWEI DIGHLQEELS SANGYPYRNS SIKRGQTAEQ TQPGDAFKQN
VTPHGNRNFE AQGAAVPRRF AKIRYDFTAR NANELSVLKD EILEVLEDNK QWWKLLNRSG
QAGYVPYNIL DVVKLEELEQ SNQRYKGDLS PRGYGPSSPT HKLPASYAGD KWGSEMLSRN
SPHDAKEQLI HQMDELNDEL LKKITNNKIQ PPHRNFKVEK PQQVFVPLTF ESSTEEVKAW
LEAKSFSKET VEHLGILTGA QLFSLNREEL KKVCGDEGNR VYSKITVEKN QLEKSRGESE
LQEIMKRRQE RIDSAN
//
