ID A0A218UWF6_9PASE Unreviewed; 589 AA.
AC A0A218UWF6;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Guanine nucleotide exchange factor VAV3 {ECO:0000313|EMBL:OWK57956.1};
DE Flags: Fragment;
GN Name=VAV3_1 {ECO:0000313|EMBL:OWK57956.1};
GN ORFNames=RLOC_00001074 {ECO:0000313|EMBL:OWK57956.1};
OS Lonchura striata domestica (Bengalese finch).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Lonchura.
OX NCBI_TaxID=299123 {ECO:0000313|EMBL:OWK57956.1, ECO:0000313|Proteomes:UP000197619};
RN [1] {ECO:0000313|EMBL:OWK57956.1, ECO:0000313|Proteomes:UP000197619}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=White83orange57 {ECO:0000313|EMBL:OWK57956.1};
RA Colquitt B.M., Brainard M.S.;
RT "Genome of assembly of the Bengalese finch, Lonchura striata domestica.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWK57956.1}.
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DR EMBL; MUZQ01000112; OWK57956.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A218UWF6; -.
DR STRING; 299123.ENSLSDP00000003508; -.
DR Proteomes; UP000197619; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:UniProt.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd20869; C1_VAV3; 1.
DR CDD; cd21264; CH_VAV3; 1.
DR CDD; cd01223; PH_Vav; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR022613; CAMSAP-like_CH_dom.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR037832; PH_Vav.
DR InterPro; IPR003096; SM22_calponin.
DR PANTHER; PTHR45818:SF1; GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV3; 1.
DR PANTHER; PTHR45818; PROTEIN VAV; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF11971; CAMSAP_CH; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR PRINTS; PR00888; SM22CALPONIN.
DR SMART; SM00109; C1; 1.
DR SMART; SM00033; CH; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000197619};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 1..119
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 192..371
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 400..502
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 513..562
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT NON_TER 589
FT /evidence="ECO:0000313|EMBL:OWK57956.1"
SQ SEQUENCE 589 AA; 68412 MW; 512593689C6EBC00 CRC64;
MEPWKQCGQW LISCKVLPPN HRVTWDTAQV FDLAQTLRDG VLLCQLLNNL RSHSINLKEI
NLRPQMSQFL CLKNIRTFLS ACCEIFGMKK SELFEAFDLF DVRDFGKVIE TLSKLSRTPI
ALGTGIRPFP TEESVDDEDI YKALPDLIDE TGVEEDEELY DCVYGEDEGG EVYEDLMKDE
AAQQPKCPEN DIRSCCLAEI KQTEEKYTET LESIEKFFMV PLKRFLSASE FDTVFINIPD
LVKIHRNLTQ DVNDSIVNKN DQNLYQIFIN YKERLVIYGQ YCSQVEIAIS CLDNISKTKE
DVKLKLEECS KRANNGKFTL RDLLVVPMQR VLKYHLLLQE LVKHTTDAME KANLKLALDA
MKDLAQYVNE VKRDNETLRE IRQFQLSIEN LNHSLLQYGR PQGDGEIRIT TLDRRARQDR
HIFLFDLAVI VCKRRGDNYE MKEIIDLQKY KITNNPTTDK ENKKWSYGFY LIHIQGENGL
EVYCKTKDLK KKWLEQFQMA LSNIRPDYAD TSFHEFKMHT FSRVTSCKVC QMLLRGTFYQ
GYLCSKCGAG AHKECLGRLD NCGRANLGEH GNVKHEKRTN GIRRSSRHV
//
