ID A0A218UWN0_9PASE Unreviewed; 509 AA.
AC A0A218UWN0;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 28-JUN-2023, entry version 15.
DE RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
GN Name=NHLRC1 {ECO:0000313|EMBL:OWK57742.1};
GN ORFNames=RLOC_00001053 {ECO:0000313|EMBL:OWK57742.1};
OS Lonchura striata domestica (Bengalese finch).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Lonchura.
OX NCBI_TaxID=299123 {ECO:0000313|EMBL:OWK57742.1, ECO:0000313|Proteomes:UP000197619};
RN [1] {ECO:0000313|EMBL:OWK57742.1, ECO:0000313|Proteomes:UP000197619}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=White83orange57 {ECO:0000313|EMBL:OWK57742.1};
RA Colquitt B.M., Brainard M.S.;
RT "Genome of assembly of the Bengalese finch, Lonchura striata domestica.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWK57742.1}.
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DR EMBL; MUZQ01000118; OWK57742.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A218UWN0; -.
DR STRING; 299123.ENSLSDP00000014828; -.
DR Proteomes; UP000197619; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd14961; NHL_TRIM32_like; 1.
DR CDD; cd16516; RING-HC_malin; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001258; NHL_repeat.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR24104:SF34; E3 UBIQUITIN-PROTEIN LIGASE NHLRC1; 1.
DR PANTHER; PTHR24104; E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED; 1.
DR Pfam; PF01436; NHL; 1.
DR Pfam; PF14634; zf-RING_5; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF101898; NHL repeat; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS51125; NHL; 2.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000197619};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 14..60
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REPEAT 112..148
FT /note="NHL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT REPEAT 152..195
FT /note="NHL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
SQ SEQUENCE 509 AA; 54075 MW; D208F2AA0777E600 CRC64;
MAAEDEAELS LLECRVCFEP YGPDGQRRPL NLPCGHVLCR GCVGALAGAE RQRLECPFCR
RLWGPAETSD CLPLLQLLEL LRPAGRGLAS ALGGGGGGAA APAGLGLRLC LGGWGSLVNP
TGVAACPGPG GLAVAHDGKK RIHVFGPSGF CLRRFGERGG ASNDIKYPLD VTVTSDGHVV
VTDGGDCSVK AFDSEGRGVL AVREGFRLPW GLDASPRSEV ILTDSEAGAL YRLAADFQRG
ELKKCQMIRS QLVSPRAVAV CPTSGAVVVI EHLRPRGPSK GSTRVTILSA EMDLIGQVDS
FGLNLVFPSR IYATAVAFDR EGRVIVTDVC SQAVICLGKP EEFPIFNPLI SHGLAYPVGL
TYTADDSLVV LDSGDHSVKS FRLSGAIPHF PFGMCTCSVT NKLGQDPLWT SFSVDLIPEH
VLQILQKRFL ILANRLEKEM LQSLNNLCGP SLDCLHYVHV PLVLESPKLS LNQHSRCGIT
SAGEGIFQLN GDVITPVTSQ AGHGGRARI
//
