ID A0A218UXL4_9PASE Unreviewed; 1651 AA.
AC A0A218UXL4;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN Name=SCN5A_1 {ECO:0000313|EMBL:OWK58503.1};
GN ORFNames=RLOC_00010857 {ECO:0000313|EMBL:OWK58503.1};
OS Lonchura striata domestica (Bengalese finch).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Lonchura.
OX NCBI_TaxID=299123 {ECO:0000313|EMBL:OWK58503.1, ECO:0000313|Proteomes:UP000197619};
RN [1] {ECO:0000313|EMBL:OWK58503.1, ECO:0000313|Proteomes:UP000197619}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=White83orange57 {ECO:0000313|EMBL:OWK58503.1};
RA Colquitt B.M., Brainard M.S.;
RT "Genome of assembly of the Bengalese finch, Lonchura striata domestica.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OWK58503.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; MUZQ01000098; OWK58503.1; -; Genomic_DNA.
DR STRING; 299123.ENSLSDP00000022607; -.
DR Proteomes; UP000197619; Unassembled WGS sequence.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF288; SODIUM CHANNEL PROTEIN; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR PRINTS; PR00170; NACHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
DR PROSITE; PS50096; IQ; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|RuleBase:RU361132, ECO:0000313|EMBL:OWK58503.1};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Reference proteome {ECO:0000313|Proteomes:UP000197619};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU361132}.
FT TRANSMEM 178..198
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 210..227
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 233..252
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 473..494
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 572..593
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 613..631
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 643..668
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 880..898
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 919..938
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 950..971
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 991..1017
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1096..1120
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1170..1193
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1213..1231
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1243..1262
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1298..1326
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1398..1421
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT DOMAIN 140..351
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 471..675
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 682..874
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT DOMAIN 878..1129
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1178..1431
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 393..426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 402..426
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1651 AA; 186418 MW; 835FB16700F29002 CRC64;
MAEFLLPGTN NFRRFTQESL AAIKKRIDAK KNCQKNTTEQ KPEEKPRPQL DLKAFQKLPA
LYGNPPPELI GEPLEDLDPY YKDHKLDFSL ELKPGLAFCG DGEDGKWQTK MSFLYSSTPR
IAHMCGTRHE IQLQSHVLEL RFTFTGIYTF ESLIKILATG FCLNEFTFLR DPWNWLDFTV
IVMAYVGAFS DLGSVSVLRT FRVLRALKTI SVVPGLKIIV GALIQSVKKL ADVMILTVFC
LSVFALIGLQ LFKGNLRQKC IRNSTGICNK TWESYEKFAN DSDDFARKNG TVDILLCGPG
AGDCPPGYKC CKIGPNPDYG FTSFDTFGWA FLSLFRLMTQ DYWERLYQQS LLGLAPAKRR
PSHGSVFNFQ IPAVEVELGS RTDLAAEGLK PRCRSLSGAP MGRRPSLQSQ RGHSSHPATP
SWARSSDGAN LDERLGVGSG LAGGSNRVHS QDPVSLEGAV LPPVMEDAGK GNLVFTGIFT
AEMILKIIAL DPYYYFQKPW NIFDSVIVTL SLIELSFPRH KSKKERGKGG TLSVLRSFRL
LRVFKLAKSW PTLNTLIKII CNSLGALSNL TLVLAIIVFI FAIVGVQLFG RSYVLNCTKI
SKDCKPRWHM KDFFHSFLII FRILCGEWIE TMWDCMVVAE PSLCLFVFLL VMVIGNLVVL
NLFIALLLNS FSADSLQTTE DDGEMKNLRI AFARIRKGFH FVKSMTWDAC CRKLRQIKKV
HKKKIKLTAQ NSLGLKSEEK KSCKENYNNE WIEKNKDKCP GLEDFVRNPN VFVCVPIAEA
EDTSEGFEDD DKLSTFTDTE CSKQLDRISS SEVSTVDLTN PEDVLKQIPE FSEDFKTPEE
CFPEGCARYF HCCLDSAAKL GGETWWNLRK TCYQIVEHSW FESFIVFMIL LSSGALAFED
IHIHKRERIQ AILGFLDKMF TYIFVLEMLL KWVAYGFKKY FTNAWCWLDF LIIDVSLINL
FGSTFGPMKS LRTLRALRPL RALSRFEGMR VVVNALLGAI PSIMNVLLVC LIFWLIFSIM
GVNLFAGKFG KCVNMTDENS VLDNNIKNKT DCGMYNNTGK IFWVNVKVNF DNVGSGYLAL
LQVKDDQPEM ENSLYMYLYF VSFIIFGSFF TLNLFVGVII DNFNQQKKKI SGEDIFMTEE
QKKYYNAMKK LGSKKPQKPI PRPLNRYQGF LFNIVTSQMF DVVIMGLICL NMITMMVETY
EQSETKTNIL SKINILFVTI FTAECVLKLL ALRQYYFSNA WNIFDLVVVI MSLVALLLSS
IGKAFEHFLP PTLFRVIRLA RIGRILRLIR GAKGIRTLLF ALMMSLPALF NIGLLLFLVM
FIYAIFGMAN FAYVKMEGGI DDMFNFQTFA NSMLCLFQIT TSAGWDGLLS PILNTGPPFC
DPNINGTVGE CGKPAIGIIY FVSYIIISFL IVVNMYIAII LENFNAATEE SAEPLGEDDF
DIFYEIWEKF DPEATQFITF SALSDFADAL PKPLCVPKPN KVELTAMDLP VVSGDKIHCL
DILFAFTKRV LGDSGELDTL RVQMEEKFMA ANPSKQSYEP ISTTLSHRQE EASATVIQRA
YRSYLLQRSL KQASYLYQHR TGSSDTLGDA APENEGLIAS MLRANYGPSR SETSSSVSIP
PSYYSVTRES SGNLVVENVE ITGNQQSPDI K
//
