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Database: UniProt
Entry: A0A218UZD3_9PASE
LinkDB: A0A218UZD3_9PASE
Original site: A0A218UZD3_9PASE 
ID   A0A218UZD3_9PASE        Unreviewed;       557 AA.
AC   A0A218UZD3;
DT   27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT   27-SEP-2017, sequence version 1.
DT   13-FEB-2019, entry version 8.
DE   RecName: Full=Hyaluronidase {ECO:0000256|RuleBase:RU610713};
DE            EC=3.2.1.35 {ECO:0000256|RuleBase:RU610713};
DE   AltName: Full=Hyaluronoglucosaminidase {ECO:0000256|RuleBase:RU610713};
GN   Name=HYAL {ECO:0000313|EMBL:OWK59137.1};
GN   ORFNames=RLOC_00014588 {ECO:0000313|EMBL:OWK59137.1};
OS   Lonchura striata domestica (Bengalese finch).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea;
OC   Estrildidae; Estrildinae; Lonchura.
OX   NCBI_TaxID=299123 {ECO:0000313|EMBL:OWK59137.1, ECO:0000313|Proteomes:UP000197619};
RN   [1] {ECO:0000313|EMBL:OWK59137.1, ECO:0000313|Proteomes:UP000197619}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=White83orange57 {ECO:0000313|EMBL:OWK59137.1};
RA   Colquitt B.M., Brainard M.S.;
RT   "Genome of assembly of the Bengalese finch, Lonchura striata
RT   domestica.";
RL   Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Random hydrolysis of (1->4)-linkages between N-acetyl-
CC         beta-D-glucosamine and D-glucuronate residues in hyaluronate.;
CC         EC=3.2.1.35; Evidence={ECO:0000256|RuleBase:RU610713};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 56 family.
CC       {ECO:0000256|PIRNR:PIRNR038193, ECO:0000256|RuleBase:RU610713}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OWK59137.1}.
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DR   EMBL; MUZQ01000084; OWK59137.1; -; Genomic_DNA.
DR   Proteomes; UP000197619; Unassembled WGS sequence.
DR   GO; GO:0004415; F:hyalurononglucosaminidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.20.20.70; -; 2.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR018155; Hyaluronidase.
DR   PANTHER; PTHR11769; PTHR11769; 2.
DR   Pfam; PF01630; Glyco_hydro_56; 2.
DR   PIRSF; PIRSF038193; Hyaluronidase; 2.
DR   PRINTS; PR00846; GLHYDRLASE56.
DR   SUPFAM; SSF51445; SSF51445; 2.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000197619};
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR038193-3};
KW   Glycosidase {ECO:0000256|RuleBase:RU610713};
KW   Hydrolase {ECO:0000256|RuleBase:RU610713};
KW   Reference proteome {ECO:0000313|Proteomes:UP000197619}.
FT   ACT_SITE    145    145       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR038193-1}.
FT   CARBOHYD    440    440       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000256|PIRSR:PIRSR038193-2}.
FT   DISULFID     57    423       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    221    237       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    448    459       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    453    510       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    512    521       {ECO:0000256|PIRSR:PIRSR038193-3}.
SQ   SEQUENCE   557 AA;  63382 MW;  7C5E59806EDEA698 CRC64;
     MGHTIAEKAQ AMDVGVTVLA AVALLTLADA QLPKPARAPP VLHKPFMVVW NAPTEQCRLR
     YKVDLDLSVF DIASNINETL SGSNVTIFYH THLGYYPYYS DNGDPVNGGV PQNESLIKHL
     SKAKSDIDYC IPMKKFQGLA VIDWENWRPQ WDRNWGNKSI YRNKSLEIVR RRHPRWPEDK
     IRKVAKEEFE NAGRSFMNNT ILLAEHMRPN GLWGYYLYPD CYNYDYKEHP QTYTGKCPPI
     ESFRNDLLLW LWKESTALYP SIYLDYILKS SPNALKFVHY RVKEAIRVAS IARKDYILPV
     FVYSRPFYAY TFHVLTEVSR QTSFKIRGGS RGWCLLICMT IQWSESLPLV QNLLVLLSSQ
     PAQDESSTLE GATSSIGHLR KNSSVLMGFE RDLVNTIGES AALGAAGVVL WGSMQYASSK
     ESCLTVKQYV DGPLGHYVIN VTSAAKLCSK VLCKKNGRCI RKNSDSSAYL HLSPSDFKIH
     DSHSERGPRF QVTGKPSLES IEAMKQRFIC QCYQGWTGIF CELPDQKLLE HWVHLGHNLI
     CCKTVYPHKF GVAEKQA
//
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